Major allergen content consistency of SQ house dust mite sublingual immunotherapy tablets and relevance across geographic regions

Nolte, Hendrik; Plunkett, Greg; Grosch, Karin; Larsen, Jørgen Nedergaard; Lund, Kaare; Bollen, Mirko

doi:10.1016/j.anai.2016.07.004

Cited by 18 publications

(14 citation statements)

References 32 publications

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“…Moreover, HDM, as well as cockroaches and Staphylococcus aureus , are known to produce various proteases, which can aggravate skin defects and more easily penetrate the skin barrier . By contrast, HDM allergens excreted in faecal pellets (major group 1 and 2 allergen source) can be airborne and more easily enter the nostrils and airways to contribute to AR or asthma …”

Section: Discussionmentioning

confidence: 99%

“…The policies regarding the production of raw materials (purified mite body or faeces or both) and the standardization methods differ in the United States and in Europe . The ratio of group 1/group 2 allergens in commercial D. farinae extracts can range from 0.9 to 20.5 . Unfortunately, the compositions and concentrations of minor allergens in HDM extracts are largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…33,34 The ratio of group 1/group 2 allergens in commercial D. farinae extracts can range from 0.9 to 20.5. 28…”

Section: Farinae Component Allergensmentioning

confidence: 99%

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Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

Park

Lee

et al. 2018

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

Park

Lee

et al. 2018

Clin Experimental Allergy

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“…Existen algunos reportes referenciados en las GM que usaron este método. [63][64][65][66][67] Estos estudios mostraron que existe gran variación entre los productos en el mercado en México 18 y que tampoco en Europa está bien definida la dosis de la ITSL, dado que existe gran variación entre las dosis de ITSL de los productos de diferentes fabricantes.…”

Section: Dosis De La Itsl Según Guías Madre Y Estudios Originales Refunclassified

GUIMIT 2019, Guía Mexicana de Inmunoterapia. Guía de diagnóstico de alergia mediada por IgE e inmunoterapia aplicando el método ADAPTE

Larenas‐Linnemann¹,

Luna-Pech²,

Rodríguez-Pérez³

et al. 2019

RAM

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Antecedentes: En México, la inmunoterapia con alérgenos (ITA) y con veneno de himenópteros (VIT) se practica tradicionalmente combinando criterios de las escuelas europea y estadounidense; los dos tipos de extractos están comercialmente disponibles en México. Para una ITA adecuada es crucial un diagnóstico oportuno.Objetivo: Presentar GUIMIT 2019, Guía Mexicana de Inmunoterapia 2019, de base amplia, actualizada, que abarca temas de diagnóstico, indicaciones, dosificación, mecanismos, efectos adversos de la ITA y expectativas con esta modalidad de tratamiento.Método: Con la participación de múltiples grupos mexicanos de alergólogos, que incluían los centros formadores universitarios en alergia e inmunología, se desarrolló el documento de la guía según la metodología ADAPTE. Las guías de inmunoterapia de la European Academy of Allergy and Clinical Immunology, The American Academy of Allergy, Asthma and Immunology, German Society for Allergology and Clinical Immunology y del American College of Allergy, Asthma, and Immunology se seleccionaron como guías fuente, ya que recibieron la puntuación AGREE-II más alta entre las guías internacionales disponibles; su evidencia conforma la base científica de GUIMIT 2019.Resultados: En GUIMIT 2019 se emiten recomendaciones fuertes o débiles (sugerencias) acerca de temas directamente relacionados con el diagnóstico in vivo o in vitro de las enfermedades alérgicas mediadas por IgE, la preparación y aplicación de ITA o VIT y sus efectos adversos; se incluye la revisión de las modalidades de ITA para el futuro. Todos los argumentos que se exponen fueron discutidos y votados con > 80 % de aprobación.Conclusión: Un grupo amplio y diverso de expertos en ITA y VIT emitió recomendaciones transculturizadas basadas en evidencia, que alcanzaron consenso; con ellas se pretende mejorar y homologar la práctica de la inmunoterapia en México.

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“…For example, Nolte et al. reported significant variations in the ratio of Der p 1 and Der p 2 among HDM extracts that are not detected by the competitive ELISA used to define potency in the United States. Similarly, Benitez and colleagues reported large variations in ratios of Der f 1 & 2 and Der p1 & 2 among five commercial products used for SLIT in Europe .…”

Section: Standardization Of Allergenic Extractsmentioning

confidence: 99%

Mass spectrometry to complement standardization of house dust mite and other complex allergenic extracts

Spiric¹,

Reuter

Rabin³

2017

Clin Experimental Allergy

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In the United States, the Center for Biologics Evaluation and Research of the US Food and Drug Administration regulates biologics used for diagnosis and treatment of allergic diseases. The Code of Federal Regulations 21CFR680.3(e) states that when measured, the potency of an allergenic extract is assessed according to its allergenic activity. As of 2016, 19 allergenic extracts are standardized for potency in the United States. While these standardized extracts constitute a minority of those available, they treat the most prevalent allergies (e.g. grass and ragweed pollens, dust mites, and cat) and those that induce life-threatening anaphylaxis (e.g. Hymenoptera venom). Standardization for potency enhances safety and efficacy of immunotherapy by minimizing the risks of variations in allergen dosing when switching from one lot of manufactured extract to another, and by providing an objective measure of stability of each lot of allergenic extract over time. Allergenic extracts that have multiple immunodominant allergenic proteins are standardized with little or no information about compositional differences among extracts. Here, we propose application of mass spectrometry towards measurement of compositional differences among extracts that may affect the efficacy and safety of allergen immunotherapy. In addition, we discuss of house dust mite allergen extracts as a prototypical complex extract that may be standardized by mass spectrometry.

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Major allergen content consistency of SQ house dust mite sublingual immunotherapy tablets and relevance across geographic regions

Cited by 18 publications

References 32 publications

Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

GUIMIT 2019, Guía Mexicana de Inmunoterapia. Guía de diagnóstico de alergia mediada por IgE e inmunoterapia aplicando el método ADAPTE

Mass spectrometry to complement standardization of house dust mite and other complex allergenic extracts

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