Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

Park, Kyung Hee; Lee, Jae Hyun; Lee, Sang Chul; Sim, Da Woon; Shin, Jung U; Park, Chang Ook; Lee, Kwang Hoon; Jeong, Kyoung Yong; Park, Jung-Won

doi:10.1111/cea.13164

Cited by 31 publications

(29 citation statements)

References 32 publications

(70 reference statements)

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“…In this study, by referring to the inclusion criteria for AR patients [25], we detected serum Notch signal expression in 100 patients with AR and 50 controls. The expression of Notch1 and Jagged1 in the AR group was significantly higher than that in the control group, and the difference was highly significant.…”

Section: Discussionmentioning

confidence: 99%

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation

Jiao

Wei

Kong

et al. 2018

Int Arch Allergy Immunol

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Background: The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. Objective: To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. Method: The sera of 100 patients with AR and 50 controls were collected to assess the differences in Notch1, Jagged1, and DLL1 (Delta-like 1) expression. Experimental mice were divided into normal control, AR, Notch inhibitor, and dexamethasone groups. Allergic symptoms, total IgE levels, and the proportion of Treg cells in the peripheral blood were detected. Notch1, Jagged1, NICD (Notch intracellular domain, also known as ICN), and Foxp3 expression and Th1/Th2/Th17-related cytokines in the spleen were detected and compared between each group of mice. Results: Compared with the control group, the expression of Notch1 and Jagged1 in patients with AR was significantly elevated (p < 0.05). The expression of Notch1 and Jagged1 in patients with severe AR was higher than that observed in the mild to moderate AR patients and positively correlated with the levels of allergen sIgE (p < 0.05). The animal experiments revealed that compared with the normal control group, the expression of Notch1, Jagged1, and NICD in the AR group was increased, Foxp3 expression was decreased, and the proportion of Treg cells was decreased (p < 0.05). Compared with the AR group, allergic symptoms and total serum IgE levels and the expression of Notch1, Jagged1, and NICD were significantly decreased in the Notch inhibited group, whereas the expression of Foxp3 and the proportion of Treg cells were increased significantly (p < 0.05). The Th2-type immune responses were also enhanced and Th1-type immune responses decreased in the AR group, but the Th1/Th2 imbalance was reversed in the Notch inhibited group. Conclusion: Notch signaling downregulates Foxp3 expression and inhibits the differentiation of Treg cells to promote the development of AR. Blocking Notch signaling may be a potential treatment for AR.

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Section: Discussionmentioning

confidence: 99%

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation

Jiao

Wei

Kong

et al. 2018

Int Arch Allergy Immunol

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“…Allergic asthma is typically caused by an inhalant allergen such as the house dust mites (HDMs) Dermatophagoides farinae ( D farinae ) and Dermatophagoides pteronyssinus . HDMs may cause a variety of diseases during the process of allergic march, including allergic rhinitis (AR), allergic conjunctivitis, and atopic dermatitis (AD) 2 …”

Section: Introductionmentioning

confidence: 99%

Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model

Park

Han

et al. 2020

Clin Experimental Allergy

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Background House dust mite (HDM) is a well‐known cause of asthma. Allergen‐specific immunotherapy (AIT) can only modify the natural course of the disease. Conventional routes of HDM AIT are subcutaneous or sublingual. Subcutaneous immunotherapy (SCIT) has a disadvantage of systemic hypersensitive reaction, and the sublingual immunotherapy has a disadvantage of local allergic reaction and low drug adherence. Objective To overcome the weak points of conventional AIT, we developed a HDM loaded biodegradable microneedle patch (MNP) for transdermal immunotherapy (TDIT). We aim to demonstrate the efficacy of TDIT in murine asthma model triggered by HDM compared with conventional SCIT. Methods To make HDM asthma mouse model, 5‐week‐old BALB/c female mice were sensitized and challenged by intranasal administration of HDM. The mice were divided into 5 groups: sham, asthma, low (10 µg) and high dose (100 µg) SCIT, and TDIT (10 µg). To make HDM loaded MNP, droplet‐born air blowing method was used. Airway hyperresponsiveness and allergic inflammation markers were analysed by bronchoalveolar lavage fluid, immunohistochemistry, serum immunoglobulin (Ig) analysis, and lung cytokine assays. Results Airway hyperresponsiveness was ameliorated by TDIT. Eosinophilic inflammation in bronchoalveolar lavage was improved without adverse reactions. Reduction of Th2 (IL‐4, IL‐5, and IL‐13) cytokines, and HDM‐specific IgE, induction of Treg (IL‐10, TGF‐β), Th1 (IFN‐γ) cytokines were observed. Eosinophilic infiltration, goblet cell hyperplasia, and subepithelial fibrosis were also alleviated by TDIT. These changes were more significant in the TDIT group than in subcutaneous AIT group. Conclusion In conclusion, HDM loaded biodegradable TDIT is a novel treatment option to treat asthma which showed more effectiveness and may have better safety profiles than conventional SCIT.

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“…82 This may account for the low prevalence of sensitization in people with respiratory symptoms, whereas reactivity in atopic dermatitis is greater. 83 Structurally, Der f 13 contains a hydrophobic binding pocket comprising a β-barrel formed from 10 antiparallel strands, 84 and its sequence similarity to cytoplasmic fatty acid binding proteins alludes to group 13 HDM allergens having a fatty acid transport function. Functional lipid-binding ability for rBlo t 13 85 and for rDer p 13 has been shown and evoked the TLR2-dependent production of IL-8 and GM-CSF by airway epithelial cells.…”

Section: Group 13 Hdm Allergens and Tlr2mentioning

confidence: 99%

Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens

Jacquet

Robinson

2019

Allergy

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House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for a range of allergic conditions. Technological advances have accelerated the identification of these allergens and characterized their putative roles within HDMs. Understanding their functional bioactivities is illuminating how they interact with How to cite this article: Jacquet A, Robinson C. Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens. Allergy.

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Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease

Abstract: Patients with respiratory allergic disease sensitize to major allergen components of HDM. Those with atopic dermatitis were sensitized to a broader range of minor allergen components of HDM (Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10).

Cited by 31 publications

References 32 publications

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation

Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model

Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens

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