Maintenance Treatment for GERD: Residual Symptoms Are Associated with Psychological Distress

Velden, Alike W van der; Wit, Niek J. de; Quartero, A. Otto; Grobbee, Diederick E.; Numans, Mattijs E.

doi:10.1159/000143796

Cited by 27 publications

(25 citation statements)

References 64 publications

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“…Therefore, patients would be expected to be suffering more severe symptoms than the average BE patient, which may explain the difference compared to our GIQLI mean of 137.2. One study that utilized the SCL-90 in GERD patients reported higher scores on dimensions of somatization, obsessiveness, interpersonal sensitivity, phobia, psychosis, and the global severity index compared to healthy controls (27, 28). While no studies have been done previously using the SCL-90R in BE patients, several studies have used the Hospital Anxiety and Depression scale (HADS) to evaluate psychological symptoms.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in GERD and Barrett's Esophagus Is Related to Gender and Manifestation of Disease

et al. 2009

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Introduction Gastroesophageal reflux disease (GERD) is a common condition that impacts patients’ health-related quality of life (HRQoL). The HRQoL of Barrett’s esophagus (BE) has been less well studied. Furthermore, it is unknown to what extent BE patients suffer from psychological distress as a result of carrying a diagnosis of a premalignant condition. We sought to compare BE and GERD (stratified by erosive (ERD) and non-erosive reflux disease (NERD)) with regards to HRQoL and psychological impact. Methods In this single-center study of subjects presenting for elective upper endoscopy, consecutive patients with BE and GERD were enrolled. Participants completed questionnaires assessing generic HRQoL (Medical Outcomes Study Short Form-36: SF-36), disease-specific HRQoL (Gastrointestinal Quality of Life Index: GIQLI), a measure of psychological distress (the Revised Hopkins Symptom Checklist: SCL-90R) and a patient-centered assessment of impact of disease severity (the GERD health-related quality of life measure: GERD HRQL). Results Patients with BE had the lowest symptom severity compared to those with NERD or ERD (GERD HRQL: 13.7 vs. 18 and 15.9 respectively, p<0.01). Those with BE also had better disease-specific quality of life compared to NERD or ERD patients (GIQLI: 137.2 vs. 124.3 and 131.0 respectively, p<0.001). After adjusting for potential confounding variables including symptom severity and gender, BE patients continued to demonstrate better disease-specific HRQoL, scoring 12.2 points higher on the GIQLI than NERD patients (95% CI 5.1 – 19.3) and 16.3 points higher than ERD patients (95% CI 5.4 – 27.3), as well as better generic HRQoL, scoring 4.8 points higher on the SF-36 physical component summary than NERD patients (95% CI 0.8 – 8.8) and 7.1 points higher than ERD patients (95% CI 1.2–13.1). There were no significant differences between groups in psychological distress, as demonstrated by the SCL-90R global severity index, though BE patients scored lower on the somatization domain compared to NERD and ERD patients. When stratified by gender, females with NERD and BE had worse disease-specific HRQoL than males. Conclusions Patients with BE have better generic and disease-specific HRQoL when compared to patients with NERD and ERD. This difference is only partially attributable to lower symptom severity amongst BE patients. Psychological distress did not differ significantly amongst groups. Female gender was associated with worsened HRQoL regardless of GERD disease manifestation. Though more precise instruments may aid in detecting any HRQoL decrements in BE patients due to perceived cancer risk or fear of developing or dying from cancer, we were unable to demonstrate an additional decrement in HRQoL due to cancer risk in subjects with BE.

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Section: Discussionmentioning

confidence: 99%

Quality of Life in GERD and Barrett's Esophagus Is Related to Gender and Manifestation of Disease

et al. 2009

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“…Evidence from a meta-analysis shows that PPIs are the most effective agents in the first-line and maintenance treatment of GERD. 12 However, PPI resistance can still occur and lead to health impairment, 13,14 suggesting the need for more potent acid-inhibitory agents.…”

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confidence: 99%

Randomised trial of acid inhibition by vonoprazan 10/20 mg once daily vs rabeprazole 10/20 mg twice daily in healthy Japanese volunteers (SAMURAI pH study)

Takeuchi

Furuta

Fujiwara

et al. 2020

Aliment Pharmacol Ther

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Background: Vonoprazan (V), a potassium-competitive acid blocker, has a more durable acid-inhibitory effect as compared with standard-dose proton pump inhibitors (PPIs) but has not been compared with 2-4 times higher daily PPI doses administered in two divided doses. Aims:To evaluate the acid-inhibitory effect of V 10/20 mg once-daily (OD; V10/ V20) vs rabeprazole (R) 10/20 mg twice-daily (BID; R20/R40) in healthy Japanese volunteers.Methods: This multicentre, randomised, open-label, two-period, crossover study compared V10 or V20 vs R20, or V20 vs R40 using three cohorts of 10 healthy Japanese adults. Within each cohort, subjects were randomised to receive V or R for 7 days and, following a washout period ≥7 days, the other treatment for 7 days. On day 6 of each period, 24-hours multichannel gastric impedance-pH monitoring was performed. Percent times pH ≥ 3, ≥4 and ≥5 (pH 3, 4 and 5 holding time ratios [HTRs])in 24 hours were evaluated as primary pharmacodynamic endpoints.Results: Acid-inhibitory effect (24-hours pH 3 HTR) of V20 was greater than those of R20 (91.0% vs 65.3%; P = .0049) and R40 (98.5% vs 85.9%; P = .0073). Similar results were obtained for 24-hours pH 4 and 5 HTRs. V20 also achieved greater nocturnal pH 4 (91.5% vs 73.2%; P = .0319) and 5 HTRs (78.8% vs 62.2%; P = .0325) as compared with R40. One subject (20%) developed diarrhoea while receiving R40 which was considered treatment-related.Conclusions: Compared with 2-4 times the standard daily dose of R, V20 exerts a more potent and durable acid-inhibitory effect. Trial identifier: UMIN000022198 (www.umin.ac.jp/ctr/index.htm). | 535TAKEUCHI ET Al.

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“…In a meta-analysis by El-Serag, persistent GERD symptoms despite medical treatment were associated with decreased psychological and physical well-being 29. van der Velden et al30 found that subjects with residual GERD symptoms had an odds ratio of 2.8 and 3.2 for anxiety and depression, respectively.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Depression and Laryngopharyngeal Reflux

Joo

Song

Pae

2017

Psychiatry Investig

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This study investigated the relationship between depression, somatization, anxiety, personality, and laryngopharyngeal reflux (LPR). We prospectively analyzed 231 patients with symptoms with LPR using the laryngopharyngeal reflux symptom index and the reflux finding score. Seventy nine (34.2%) patients were diagnosed with LPR. A significant correlation was detected between the presence of LPR and total scores on the Patient Health Questionnaire-9 (5.6±5.3 vs. 4.0±4.6, p=0.017) and the 7-item Generalized Anxiety Disorder Scale (4.3±4.9 vs. 3.0±4.5, p=0.041). LPR was significantly more frequent in those with depression than in those without (45.6% vs. 27.0%, p=0.004). A multivariate analysis confirmed a significant association between the presence of LPR and depression (odds ratio, 1.068; 95% confidence interval, 1.011–1.128; p=0.019). Our preliminary results suggest that patients with LPR may need to be carefully evaluated for depression.

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Maintenance Treatment for GERD: Residual Symptoms Are Associated with Psychological Distress

Cited by 27 publications

References 64 publications

Quality of Life in GERD and Barrett's Esophagus Is Related to Gender and Manifestation of Disease

Quality of Life in GERD and Barrett's Esophagus Is Related to Gender and Manifestation of Disease

Randomised trial of acid inhibition by vonoprazan 10/20 mg once daily vs rabeprazole 10/20 mg twice daily in healthy Japanese volunteers (SAMURAI pH study)

Relationship between Depression and Laryngopharyngeal Reflux

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