Maintenance chemotherapy for ovarian cancer

Mei, Ling; Chen, Hui; Dong, Wei; Fang, Fang; Liu, Guan J; Xie, Huan; Wang, Xun; Zou, Juan; Han, Xu; Feng, Dan

doi:10.1002/14651858.cd007414.pub3

Cited by 49 publications

(19 citation statements)

References 33 publications

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“…Ovarian cancer is a common cancer of the female reproductive organs, and is associated with the highest death rates among all gynecological cancers (Chen et al 2013). Cisplatin chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

Küçükkaya

Başoğlu

Erdag

et al. 2019

gpb

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Intracellular calcium concentration ([Ca 2+ ] i) may have an important role in the development of chemoresistance, which is an essential problem in cancer chemotherapy. Cisplatin (DDP), which modulates the intracellular calcium concentration by different mechanisms, is an antineoplastic agent with high success rate in cancer therapies. We investigated the regulatory role of [Ca 2+ ] in cisplatin resistance in epithelial ovarian cancer cell line, in MDAH-2774, and its chemoresistant subclone MDAH-2774/DDP. The measurement of [Ca 2+ ] i using fluorescence microscope, and flow cytometry revealed that the amount of intracellular calcium decreased in cisplatin resistant cells compared to the amounts in parental cells. mRNA expression profiles of calcium homeostasisassociated major genes (IP 3 R1/2/3, RYR1/2, SERCA1/2/3, NCX1/2/3, PMCA1/2/3, and PMCA4) decreased in cisplatin resistant cell line in comparison to the expression profiles in parental cells. Owing to the changes in the expression of genes involved in calcium regulation, these results show, drug resistance may be prevented by introducing a new perspective on the use of inhibitors and activators of these genes, and thus of cytostatic treatment strategies, due to changes in the expression of genes involved in calcium regulation.

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Section: Discussionmentioning

confidence: 99%

Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

Küçükkaya

Başoğlu

Erdag

et al. 2019

gpb

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“…The majority of these EOC categories are heterogeneous in nature, with distinct epidemiological and genetic factors, molecular profiles and behavioral responses toward chemotherapy and other treatments (Prat, 2012a; Groen et al, 2015), contributing to the difficulties in designing effective therapeutic strategies. Also, the lack of an early screening strategy (Buys et al, 2011) and the rather high rate of tumor relapse (Mei et al, 2013) increase the mortality rates in ovarian cancer patients. Therefore, it is necessary to develop more precise and effective treatment strategies in order to improve the survival rates for women diagnosed with this cancer.…”

Section: Introductionmentioning

confidence: 99%

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

2016

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Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed.

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“…Mei and coworkers [1] have recently published a metaanalysis on this issue based on 4 randomised controlled trials (RCTs) that used different types of conventional cytotoxic chemotherapy (e.g. platinum agents, doxorubicin, topotecan or paclitaxel).…”

Section: Resultsmentioning

confidence: 99%

“…The distinction between inconclusiveness and futility is not assumption-free, but depends on the choice of a specific threshold for incremental clinical effectiveness. In our TSA, this threshold was set at a relative risk reduction (RRR) of 20%; this value was derived from the outcomes reported in the "most positive" trials evaluating remission rates and/or progression [1]. Figure 1 shows the results of our TSA in which "events" were cases of progression at 3 years.…”

Section: Resultsmentioning

confidence: 99%

Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis

Messori¹,

Fadda²,

Maratea³

et al. 2013

JCT

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In patients with epithelian ovarian cancer who have achieved remission after initial surgery and induction chemotherapy, the role of maintenance chemotherapy is controversial. We carried out a trial-sequential analysis that included 4 randomised controlled trials. The end-point was progression at 3 years while the boundary for non-inferiority was set at ±20% in risk ratio. The results of our trial-sequential analysis indicated the futility of maintenance chemotherapy, i.e. proof of no effectiveness. Consequently, no further trials of this type should be performed to assess the effectiveness of this intervention in this clinical condition.

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Maintenance chemotherapy for ovarian cancer

Abstract: There is no evidence to suggest that the use of platinum agents, doxorubicin or paclitaxel used as maintenance chemotherapy is more effective than observation alone. Further investigations regarding the effect of paclitaxel used as maintenance chemotherapy are required.

Cited by 49 publications

References 33 publications

Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis

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