“…These analyses indicated higher expression across several classes of mitochondrial translation proteins, including mitochondrial elongation factors (TUFM (Tu translation elongation factor, mitochondrial) and GFM1 (G elongation factor, mitochondrial, 1)), mitochondrial ribosomal proteins (mitochondrial ribosomal protein (MRP) S5, S7, S9, S16, S22, S25, L12, and L46), and proteins in charge of mitochondrial tRNA synthesis and function (DARS2 (aspartyl-tRNA synthetase 2), YARS2 (tyrosyl-tRNA synthetase 2), and PUS1 (pseudouridylate synthase 1); Figures 1a and b; Table 1). The enrichment in mtDNA-encoded ETC subunits and mitochondrial translation proteins in OxPhos-DLBCLs is further consistent with higher expression of proteins involved in mtDNA maintenance (SSBP1 (single-stranded DNA-binding protein 1)) and transcription (TFAM (mitochondrial transcription factor A) and LRPPRC (leucine-rich pentatricopeptide repeat containing protein)) in this DLBCL subtype 18,28 ( Figure 1f; Table 1; Supplementary Table 2).…”