Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents

Danciu, Corina; Avram, Speranța; Pavel, Ioana Zinuca; Ghiulai, Roxana; Dehelean, Cristina; Alexa, Ersilia; Minda, Daliana; Petrescu, Cristina; Moacă, Elena-Alina; Şoica, Codruţa

doi:10.2174/1389450118666171109150731

Cited by 63 publications

(37 citation statements)

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“…The phenolic acids, flavonoids, and isoflavones from plants were reported to have anti-inflammatory activity [36–39]. Therefore, the anti-inflammatory properties of E. planum and C. benedictus polyphenolic-rich extracts may be assigned to the synergic effect of ursolic acid and polyphenols such as rutin, chlorogenic acid, rosmarinic acid, genistin, and daidzein previously investigated for anti-inflammatory effects [36–39].…”

Section: Resultsmentioning

confidence: 99%

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Păun

Neagu

Moroeanu

et al. 2019

BioMed Research International

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This study evaluated the biological activities of Eryngium planum and of Cnicus benedictus extracts enriched in polyphenols obtained by nanofiltration. The HPLC-MS analysis showed that E. planum contains mainly flavonoids, especially rutin, while in C. benedictus extracts show the high concentration of the phenolic acids, principally the chlorogenic acid and sinapic acid. Herein, there is the first report of ursolic acid, genistin, and isorhamnetin in E. planum and C. benedictus. C. benedictus polyphenolic-rich extract showed high scavenging activity (IC50=0.0081 mg/mL) comparable to that of standard compound (ascorbic acid) and a higher reducing power (IC50= 0.082 mg/mL), with IC50 having a significantly lower value than IC50 for ascorbic acid. Both extracts were nontoxic to NCTC cell line. Among the investigated herbs, E. planum polyphenolic-rich extract showed the highest inhibitory activities with the IC50 value of 31.3 μg/mL for lipoxygenase and 24.6 μg/mL for hyaluronidase. Both polyphenolic-rich extracts had a higher inhibitory effect on α-amylase and α-glucosidase than that of the acarbose. The synergistic effect of ursolic acid, rutin, chlorogenic acid, rosmarinic acid, genistin, and daidzein identified in polyphenolic-rich extracts could be mainly responsible for the pharmacological potentials of the studied extracts used in managing inflammation and diabetes.

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Section: Resultsmentioning

confidence: 99%

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Păun

Neagu

Moroeanu

et al. 2019

BioMed Research International

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“…Moreover, genistein suppressed Bcl-2, Bcl-xL, c-inhibitor of apoptosis protein 1 (c-IAP1), survivin, and NF-κB in C200 and A2780 cells [94], increased caspase-3 activity in HT-29 colon cancer cells [95] and activated intrinsic apoptotic signaling pathway in HCT-116 and LoVo cells [96]. Isoflavonoid daidzein also acted as phytoestrogen [97]. It promoted cytochrome c release from mitochondria, leading to caspase 7 and 9 activation and also altered Bax/Bcl-2 ratio in MCF-7 cells [60,98].…”

Section: Flavonoids In Apoptosismentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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“…During oxidative stress, interleukins and inflammatory mediators are produced. Isoflavones from natural products have shown anti-inflammatory properties in vitro and in vivo [157]. Verdrengh et al [158] showed that subcutaneous treatment with genistein was able to suppress the delayed-type hypersensitivity reaction to oxazolone and the granulocyte-mediated response.…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

Camargo

Favero

Morzelle

et al. 2019

IJMS

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Legume seeds are rich sources of protein, fiber, and minerals. In addition, their phenolic compounds as secondary metabolites render health benefits beyond basic nutrition. Lowering apolipoprotein B secretion from HepG2 cells and decreasing the level of low-density lipoprotein (LDL)-cholesterol oxidation are mechanisms related to the prevention of cardiovascular diseases (CVD). Likewise, low-level chronic inflammation and related disorders of the immune system are clinical predictors of cardiovascular pathology. Furthermore, DNA-damage signaling and repair are crucial pathways to the etiology of human cancers. Along CVD and cancer, the prevalence of obesity and diabetes is constantly increasing. Screening the ability of polyphenols in inactivating digestive enzymes is a good option in pre-clinical studies. In addition, in vivo studies support the role of polyphenols in the prevention and/or management of diabetes and obesity. Soybean, a well-recognized source of phenolic isoflavones, exerts health benefits by decreasing oxidative stress and inflammation related to the above-mentioned chronic ailments. Similar to soybeans, chickpeas are good sources of nutrients and phenolic compounds, especially isoflavones. This review summarizes the potential of chickpea as a substitute for soybean in terms of health beneficial outcomes. Therefore, this contribution may guide the industry in manufacturing functional foods and/or ingredients by using an undervalued feedstock.

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Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents

Cited by 63 publications

References 0 publications

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Chemical and Bioactivity Evaluation ofEryngium planumandCnicus benedictusPolyphenolic-Rich Extracts

Flavonoids as Anticancer Agents

Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits

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