Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Styshova, Olga; Popov, Alexander; Artyukov, A. A.; Климович, А. А.

doi:10.3892/etm.2017.4217

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…(Blechnaceae), as well as some orders of the monocotyledonous plants, and the rosids and asterids within the eudicotyledonous plants. The presence of RA in the marine hydrophilus angiosperms such as Zostera marina Linnaeus (eelgrass), Z. noltii Hornemann (dwarf eelgrass) has also been reported [ 67 , 68 , 69 ]. However, to date RA has not been reported in any of the gymnosperms [ 64 , 66 ].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid

et al. 2020

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Modern lifestyle factors, such as physical inactivity, obesity, smoking, and exposure to environmental pollution, induce excessive generation of free radicals and reactive oxygen species (ROS) in the body. These by-products of oxygen metabolism play a key role in the development of various human diseases such as cancer, diabetes, heart failure, brain damage, muscle problems, premature aging, eye injuries, and a weakened immune system. Synthetic and natural antioxidants, which act as free radical scavengers, are widely used in the food and beverage industries. The toxicity and carcinogenic effects of some synthetic antioxidants have generated interest in natural alternatives, especially plant-derived polyphenols (e.g., phenolic acids, flavonoids, stilbenes, tannins, coumarins, lignins, lignans, quinines, curcuminoids, chalcones, and essential oil terpenoids). This review focuses on the well-known phenolic antioxidant rosmarinic acid (RA), an ester of caffeic acid and (R)-(+)-3-(3,4-dihydroxyphenyl) lactic acid, describing its wide distribution in thirty-nine plant families and the potential productivity of plant sources. A botanical and phytochemical description is provided of a new rich source of RA, Satureja khuzistanica Jamzad (Lamiaceae). Recently reported approaches to the biotechnological production of RA are summarized, highlighting the establishment of cell suspension cultures of S. khuzistanica as an RA chemical biofactory.

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Section: Phenolic Compoundsmentioning

confidence: 99%

Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid

et al. 2020

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“…It seems to be a consequence of the effect of fat in food which induces impairment of lipid profile and elevates the degree of lipid peroxidation leading to blood pressure modulation (48) . In our experiments, even energy restriction or RA administration resulted in blood pressure drop, probably as a consequence of anti-inflammatory and antioxidant properties of RA (49) as well as of a beneficial effect of energy restriction (50) .…”

Section: Discussionmentioning

confidence: 63%

Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model

et al. 2020

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Decreasing high fat and high carbohydrate intake, together with the administration of natural bioactive drugs is assumed to have a protective effect in the prevention and amelioration of metabolic syndrome (MetS). The aim of the study was to evaluate effects of diet improvement and/or a phenolic compound - rosmarinic acid (RA) administration (100 mg/kg/day) on metabolic as well as functional changes of vessels and hippocampus caused by MetS-like conditions. MetS-like conditions were induced by high-fat-fructose diet (HFFD) in Prague hereditary hypertriacylglycerolemic rats. The effect of diet improvement and RA administration was studied using biochemical and functional measurements. Consumption of HFFD by hypertriacylglycerolemic rats resulted in the development of conditions like MetS. The fat and fructose restriction from the diet led to amelioration of basic indicators of metabolic state in rats fed HFFD and to amendment parameters of glucose-tolerance test and reduction of the IL-1β serum levels. Moreover, aortic endothelial function was improved with an impact on blood pressure. The functional measurement of electrophysiology of the hippocampus showed that long-term potentiation of neuronal transmission course deteriorated after HFFD was improved by caloric restriction. Oral administration of RA had a supporting effect not only on lipid and glucose metabolism but also on the vascular endothelium. Combination of both types of therapy induced beneficial effect on glucose tolerance and lipid peroxidation. Thus, combined improvement of diet habits and treatment with natural bioactive drugs is assumed to have protective effect in prevention and amelioration of MetS.

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“…Bioflavonoids act as signal regulators of various biochemical pathways in the cells and tissues of the body [ 4 , 7 , 8 , 9 , 46 ]. Flavonoids and their conjugates have unique mechanisms of protective action.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Flavonoids are low-toxic, natural compounds that have a variety of biological activities [ 1 , 2 , 3 , 4 , 5 ]. They regulate various signaling pathways in cells, playing an important role in the prevention and treatment of pathologies associated with inflammation (atherosclerosis, metabolic syndrome, diabetes mellitus, immunological, oncological and neurodegenerative diseases) [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Flavonoids have an antispasmodic effect, including on the vessels of the heart and brain, have a positive effect on metabolic processes in the myocardium, have an antiarrhythmic effect, inhibit platelet aggregation and their adhesion to the epithelium of the vascular wall, and normalize blood rheology and carbohydrate metabolism, providing, first of all, anti-inflammatory and immunomodulatory action [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate

et al. 2022

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The global spread of the metabolic syndrome, oncological and viral diseases forces researchers to pay increased attention to the secondary metabolites of marine hydrobionts, which often have a high therapeutic potential in the treatment of these pathologies and are effective components of functional food. The flavone luteolin (LT), as one of the most widely distributed and studied plant metabolites, is distinguished by a diverse spectrum of biological activity and a pleiotropic nature of the mechanism of action at the molecular, cellular and organismal levels. However, there is still practically no information on the spectrum of biological activity of its sulfated derivatives, which are widely represented in seagrasses of the genus Zostera. In the present work, a comparative study of the pharmacological properties of LT and its 7,3′-disulfate was carried out with a brief analysis of the special role of sulfation in the pharmacological activity of flavonoids.

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Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Cited by 16 publications

References 43 publications

Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid

Powerful Plant Antioxidants: A New Biosustainable Approach to the Production of Rosmarinic Acid

Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model

Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate

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