Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate

Abstract

The global spread of the metabolic syndrome, oncological and viral diseases forces researchers to pay increased attention to the secondary metabolites of marine hydrobionts, which often have a high therapeutic potential in the treatment of these pathologies and are effective components of functional food. The flavone luteolin (LT), as one of the most widely distributed and studied plant metabolites, is distinguished by a diverse spectrum of biological activity and a pleiotropic nature of the mechanism of action at the molecular, cellular and organismal levels. However, there is still practically no information on the spectrum of biological activity of its sulfated derivatives, which are widely represented in seagrasses of the genus Zostera. In the present work, a comparative study of the pharmacological properties of LT and its 7,3′-disulfate was carried out with a brief analysis of the special role of sulfation in the pharmacological activity of flavonoids.

Endometriosis Treatment: Role of Natural Polyphenols as Anti-Inflammatory Agents

“…Dietary sources rich in LUT include several vegetables, such as carrot, broccoli, parsley, olive, thyme and clove. The active metabolites or derivatives of LUT, such as luteolin-glucuronide and luteolin 7-glucoside, are known to have anti-oxidant, anti-tumoral, anti-apoptotic, anti-microbial and anti-inflammatory properties [ 101 , 104 ]. The anti-inflammatory activity of LUT is achieved at micromolar concentrations by inhibiting the expression of COX-2 and the production of several pro-inflammatory mediators such as TNF-α and IL-6, hindering macrophage activation and release of excessive amounts of PGs [ 101 , 105 ].…”