Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Park, Jun‐Beom; Lee, Myung Sun; Young, Eun; Lee, Jin Sung; Sul, Ji Young; Song, In Sang; Kim, Ji Yeon

doi:10.1248/bpb.b12-00352

Cited by 44 publications

(32 citation statements)

References 45 publications

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“…This results of the study have shown that magnolol 2 downregulated expression of the antiapoptotic protein Bcl-2, upregulated expression of pro-apoptotic protein p53 and Bax, and caused the release of mitochondrial cytochrome c. Magnolol 2 induced p53 and Bcl-2 expression was abolished in the presence of magnolol compound. Magnolol inhibited migration and invasion of HCT-116 cells through AMPK activation [24]. These findings demonstrate that AMPK mediates the anticancer effects of magnolol through apoptosis in HCT-116 cells.…”

Section: Fadilah Et Alsupporting

confidence: 51%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the cancer cells and animal models.

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Section: Fadilah Et Alsupporting

confidence: 51%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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“…Interestingly, MAG treatment with colon cancer induced apoptosis by upregulating the expression of the p27Cip1 protein [133]. Park J.B. et al, reported that HCT-116 colon cancer cells upon treatment with MAG activated AMP-activated protein kinase (AMPK), enhanced the expression of pro-apoptotic protein Bax and p53 and downregulated the anti-apoptotic protein Bcl-2 [132]. Another study conducted by Kang Y.J.…”

Section: Effect Of Magnolol In Different Cancersmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

134

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The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

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“…Another group of polyphenols of interest are lignans and particularly, magnolol (Table 1), a compound isolated from roots and barks of Magnolia officinalis that has recently shown interesting anticancer activity through AMPK modulation [31,32,33]. The treatment of HCT-116 human colon cancer cells with this compound induced apoptosis and exerted anti-proliferative effects in a dose and time dependent manner.…”

Section: Nutraceutical Compounds and Cancermentioning

confidence: 99%

Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds

Marín-Aguilar

Pavillard

Giampieri

et al. 2017

IJMS

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Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. In this sense, AMPK maintains cellular energy homeostasis by induction of catabolism and inhibition of ATP-consuming biosynthetic pathways to preserve ATP levels. Several studies indicate a reduction of AMPK sensitivity to cellular stress during aging and this could impair the downstream signaling and the maintenance of the cellular energy balance and the stress resistance. However, several diseases have been related with an AMPK dysfunction. Alterations in AMPK signaling decrease mitochondrial biogenesis, increase cellular stress and induce inflammation, which are typical events of the aging process and have been associated to several pathological processes. In this sense, in the last few years AMPK has been identified as a very interesting target and different nutraceutical compounds are being studied for an interesting potential effect on AMPK induction. In this review, we will evaluate the interaction of the different nutraceutical compounds to induce the AMPK phosphorylation and the applications in diseases such as cancer, type II diabetes, neurodegenerative diseases or cardiovascular diseases.

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Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway

Cited by 44 publications

References 45 publications

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds

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