Magnolol blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries

Kuo, Daih‐Huang; Tsai, Shin-Wen; Pan, Min‐Hsiung

doi:10.1016/j.foodchem.2010.12.101

Cited by 8 publications

(6 citation statements)

References 27 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relaxed the coronary artery with an IC 50 value of 5.78 μM and dose-dependently inhibited iNOS and COX-2 protein expression Kuo et al (2011) Human aortic smooth muscle cells (HASMCs)…”

Section: Right Coronary Arteries From Hearts Of Pigsmentioning

confidence: 99%

“…MG (20 μM) suppressed VSMC proliferation and DNA synthesis by inhibiting the expression of cyclin D1/E and cyclin-dependent kinase 2 and 4, ROS production, and activation of renin–angiotensin system, MEK, and ERK1/2 ( Karki et al, 2013a ; Wu et al, 2015 ). Additionally, it (1–100 μM) could play the role of vasodilator and eliminate superoxide anion by relaxing right coronary arteries (separated from hearts of pigs) in a dose-dependent manner and controlling the expression levels of iNOS and COX-2, with an IC 50 value of 5.78 μM ( Kuo et al, 2011 ). Further pharmacological research in this field was needed to reveal the mechanism by which MG inhibited homocysteine-induced endothelium-dependent vasodilation damage.…”

Section: Pharmacological Activitymentioning

confidence: 99%

See 1 more Smart Citation

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Yong

Zeng

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Magnolol (MG) is one of the primary active components of Magnoliae officinalis cortex, which has been widely used in traditional Chinese and Japanese herbal medicine and possesses a wide range of pharmacological activities. In recent years, attention has been drawn to this component due to its potential as an anti-inflammatory and antitumor drug. To summarize the new biological and pharmacological data on MG, we screened the literature from January 2011 to October 2020. In this review, we provide an actualization of already known anti-inflammatory, cardiovascular protection, antiangiogenesis, antidiabetes, hypoglycemic, antioxidation, neuroprotection, gastrointestinal protection, and antibacterial activities of MG. Besides, results from studies on antitumor activity are presented. We also summarized the molecular mechanisms, toxicity, bioavailability, and formulations of MG. Therefore, we provide a valid cognition of MG.

show abstract

“…Relaxed the coronary artery with an IC 50 value of 5.78 μM and dose-dependently inhibited iNOS and COX-2 protein expression Kuo et al (2011) Human aortic smooth muscle cells (HASMCs)…”

Section: Right Coronary Arteries From Hearts Of Pigsmentioning

confidence: 99%

Section: Pharmacological Activitymentioning

confidence: 99%

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Yong

Zeng

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…4 In fact, endothelium alterations in vasodilator integrity and capacity, and the increased inflammation are all involved in the early stages of CVD, including atherosclerosis. [5][6][7] Interestingly, recent research has surprisingly reported that dietary phosphatidylcholine had a particularly close connection to the build-up of arterial plaque and CVD. 8 The research also showed that dietary supplementation of mice with choline promoted upregulation of multiple macrophage scavenger receptors linked to atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Myricetin derived from Hovenia dulcis Thunb. ameliorates vascular endothelial dysfunction and liver injury in high choline-fed mice

et al. 2015

View full text Add to dashboard Cite

The present study was conducted to explore the protective effects of myricetin (MYR) purified from Hovenia dulcis Thunb. against vascular endothelial dysfunction and liver injury in mice fed with 3% dietary choline water. MYR was shown to possess strong scavenging activities against DPPH˙, HO˙, and O2˙(-) and ferric-reducing antioxidant power in vitro. Mice fed 3% dietary choline water for 8 weeks significantly displayed vascular endothelial dysfunction and liver oxidative stress (p < 0.01). Furthermore, continuous administration of MYR at 400 and 800 mg per kg bw in choline-fed mice could significantly decrease the high choline diet-induced elevation of serum total cholesterol (TC), total triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), endothelin 1 (ET-1) and thromboxane A2 (TXA2) levels as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, while the choline-induced decline of serum high density lipoprotein-cholesterol (HDL-C), endothelin nitric oxide synthase (eNOS), nitric oxide (NO) and prostaglandin I2 (PGI2) levels could be markedly elevated in mice (p < 0.05, p < 0.01). Meanwhile, MYR at 400 and 800 mg per kg bw also increased hepatic total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities and decreased hepatic malonaldehyde (MDA) and non-esterified fatty acid (NEFA) levels in mice, relative to choline-treated mice (p < 0.05, p < 0.01). These results together with conventional haematoxylin and eosin (H&E) and Oil Red O staining observation of the liver and vascular tissues suggested that MYR exerted a significant protective role against high choline diet-induced endothelial dysfunction and liver injury in mice. This is the first report showing that high intake of dietary choline can induce liver damage and that MYR can ameliorate choline-induced vascular endothelial dysfunction and liver injury.

show abstract

“…Although some researchers have investigated the antioxidant activity of magnolol extracted from Cortex Magnoliae Officinalis [8], few of those studies were done in vivo. Therefore, the objective of this experiment was to investigate the anti-diarrhea property of magnolol using the castor oil-induced diarrhea mice model and small intestinal transit (SIT) and to determine the antioxidant activity of magnolol through examination of antioxidant enzyme responses at both enzymatic and transcript levels.…”

Section: Introductionmentioning

confidence: 99%