Anti-diarrhea and anti-oxidant properties of Magnolol

Pang, YL; Han, X. F.; Bamikole, M. A.; Gong, ZH; Tang, SX; Tan, Z-L; Xiao, W.; Zhou, CS; M, Wang; Deng, YL

doi:10.4314/tjpr.v12i1.14

Cited by 12 publications

(23 citation statements)

References 22 publications

(18 reference statements)

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“…5), suggesting that magnolol induce CAT activity and that could provide antioxidant protection in the cells against oxidative stress. Studies have shown that magnolol treatment increased the CAT and SOD activity in the Kunming mice [20]. Our study also suggests using yeast as a model organism to study the antioxidant property of a natural compound in vivo.…”

Section: Discussionmentioning

confidence: 63%

Evaluation of Antioxidant Activity of Magnolol in Saccharomyces Cerevisiae

Subramaniyan

Dyavaiah

2018

Int J Pharm Pharm Sci

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Objective: To investigate the antioxidant activity of magnolol in Saccharomyces cerevisiae (S. cerevisiae) model. Methods:Antioxidant activity of magnolol was demonstrated in S. cerevisiae using spot assay, colony forming unit (CFU) assay, detection of reactive oxygen species (ROS) by fluorescent microscopy and spectrofluorometer, lipid peroxidation (LPO) and catalase (CAT) assay. Results:A dose-dependent increase in sensitivity of S. cerevisiae was observed with increase in hydrogen peroxide (H2O2) concentration. At 1.5 mmol concentration of H2O2, we observed 50 % of cell survivability in CFU and spot assay results. The sensitivity of S. cerevisiae to H2O2 was protected by magnolol treatment. In spot assay, magnolol pre-treatment showed the similar growth pattern as that of control and in CFU assay 75 % of survivability was observed. Fluorescence microscopic images and fluorescence intensity levels using 2´, 7´-dichlorodihydrofluoresceindiacetate (H2DCFDA) showed less number of fluorescence cells and 1.2 fold decrease in fluorescence intensity in magnolol pre-treated cells. The cellular protection in the cells pre-treated with magnolol followed by H2O2 Conclusion:The result of the present study demonstrates that magnolol protects S. cerevisiae cells from H was correlated with the decreased LPO and increase in CAT activity was recorded. O2

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Section: Discussionmentioning

confidence: 63%

Evaluation of Antioxidant Activity of Magnolol in Saccharomyces Cerevisiae

Subramaniyan

Dyavaiah

2018

Int J Pharm Pharm Sci

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“…A major bioactive constituent of the bark of Magnolia officinalis is 5,5 -diallyl-2,2 -dihydroxybiphenyl, a hydroxylated biphenyl compound called magnolol (MG) whose anti-inflammatory [4], anti-oxidative [5], anti-diabetic, anti-tumorgenic [6], anti-neurodegenerative, anti-depressant and anti-microbial [7] properties have been recently demonstrated. This compound also regulates hormones, exhibits positive gastrointestinal and uterus modulatory effects, offers cardio-vascular and liver protection and is effective in pain control [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

et al. 2017

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Magnolol (MG) is a small-molecule neolignan polyphenolic compound isolated from the genus Magnolia. The anti-inflammatory, anti-oxidative, anti-diabetic, anti-tumorgenic, anti-neurodegenerative, anti-depressant and anti-microbial properties of MG are well documented in recent literature. These fascinating multiple biological activities of MG encourage research about the development of new delivery and administration approaches able to maximize its potential benefits. This study describes the amino-functionalization of the SBA-15 (Santa Barbara Amorphous) mesoporous matrix by post-synthesis grafting using APTES (3-aminopropyltriethoxysilane) and the characterization of amino-functionalized mesoporous silica SBA-15 loaded with MG in order to achieve modified drug delivery systems. The amino-functionalization of silica SBA-15 was carried out by grafting by refluxing in dry toluene. The powders obtained were characterized texturally by Brunauer-Emmett-Teller (BET) surface area analysis measurements and morphologically by scanning electron microscopy. MG loading degree in the nanoporous matrix was determined by the HPLC method at λ = 290 nm. Results showed that by grafting the amino groups in the silica SBA-15, we obtained amino-functionalized silica SBA-15 with an ordered structure, with specific surfaces and pore sizes that differ from the original matrix, which was reflected in the amount of MG immobilized and release kinetics profile.

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“…The current studies indicate that honokiol exerts significant antidiarrheal and antimotility activity. Furthermore, our previous studies have also showed that magnolol has both antidiarrheal and antimotility effects [12]. Honokiol and magnolol are two biphenolic compounds.…”

Section: Groupmentioning

confidence: 99%

“…The remaining three groups were orally administered by gavage with the honokiol extract solution at doses of 25 (Honokiol 25), 50 (Honokiol 50) or 100 (Honokiol 100) mg honokiol/kg BW respectively at the same volume. The dose setting of honokiol in this study referred to results of Hsieh et al [10], Atanasov et al [11] and Pang et al [12].…”

Section: Castor Oil-induced Diarrheamentioning

confidence: 99%

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Antidiarrhea and antioxidant activities of Honokiol extract from <i>Magnoliae officinalis cortex</i> in mice

Han¹,

Pang²,

Liu³

et al. 2014

Trop. J. Pharm Res

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Purpose: To evaluate the antidiarrhea and antioxidant properties of honokiol extracted from Magnoliae officinalis cortex (bark of Magnolia officinalis), an important medical material in traditional Chinese 16 % in comparison with -neostigmine control group-(59.0 % vs. 70 .1%). Compared with control (no honokiol), the activities of catalase (CAT), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) in the plasma (CAT, 7.31 vs. 13.21 U/mL; 439.6 vs. 608.9 U/m; 82.2 vs. 109.8 U/mL) and liver (CAT, 7.73 vs. 14.39 U/mg; 167.6 vs. 202.7 U/mg; 44.3 vs. 53.9 U/mg) were significantly enhanced by honokiol (p < 0.01). CAT and GSH-Px gene expressions were also significantly enhanced by honokiol (p < 0.05), compared with control (no honokiol) (CAT, 0.32 vs. 0.39; 4.49 vs. 5.80

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Anti-diarrhea and anti-oxidant properties of Magnolol

Abstract: Purpose: To provide an experimental basis for the anti-diarrheal and anti-oxidant properties of the bark extract of Magnolia officinalis 60.34 ± 5.17, 59.61 ± 7.66, and 54.12 ± 7.27 %, respectively, as against 70.1 ± 6.89

Cited by 12 publications

References 22 publications

Evaluation of Antioxidant Activity of Magnolol in Saccharomyces Cerevisiae

Evaluation of Antioxidant Activity of Magnolol in Saccharomyces Cerevisiae

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

Antidiarrhea and antioxidant activities of Honokiol extract from <i>Magnoliae officinalis cortex</i> in mice

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