Magnolol and Honokiol: Inhibitors against Mouse Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors

Han, Sang Jun; Bae, Eun‐Ah; Trinh, Hien T.; Yang, Jiao; Youn, UiJung; Bae, KiHwan; Kim, Dong-Hyun

doi:10.1248/bpb.30.2201

Cited by 36 publications

(27 citation statements)

References 19 publications

(7 reference statements)

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“…Magnolol has been reported to exert various biological effects, such as preventing platelet aggregation through the inhibition of thromboxane formation, 4) scavenging hydroxyl radicals in UV-induced mutations of Salmonella typhimurium TA102, 5) blocking Ca 2ϩ -channels, 6) preventing inflammation through the inhibition of cyclooxygenase and lipooxygenase, 7) discouraging tumor development through inhibition of tumor cell invasion and induction of tumor cell apoptosis, 8,9) inhibiting the promotion of carcinogenesis induced by 12-O-tetradecanoylphorbol-13-acetate, 10) reducing the inflammatory phase of the formalininduced licking response (antinociceptive effect), 11) improving the response to immunoglobulin E (IgE)-induced allergies, 12) and exerting a protective effect on sepsis-induced inflammation and intestinal dysmotility. 13) All of these effects are also thought to influence cancer chemoprevention.…”

mentioning

confidence: 99%

Anti-clastogenic Effect of Magnolol-Containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on Benzo(a)pyrene-Induced Clastogenicity in Mice

Saito

Fukushima

Nagase

2009

Biological & Pharmaceutical Bulletin

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Magnolol was previously shown to inhibit genotoxicity induced by environmental mutagens both in vitro and in vivo. Here, we investigate the effects of the magnolol-containing kampo (traditional) medicines Hange-kobokuto, Dai-joki-to, and Goshaku-san, as well as Magnoliae Cortex, on the clastogenesis induced by benzo(a)pyrene (B(a)P) using the mouse micronucleus test. The mice were first treated with a single intraperitoneal injection of B(a)P, followed by a single oral dose of Hange-koboku-to, Dai-joki-to, Goshaku-san, or Magnoliae Cortex. Peripheral blood specimens were prepared 48 h after B(a)P administration and analyzed using the acridine orange (AO) technique. The anti-clastogenic mechanisms employed by the kampo medicines and Magnoliae Cortex were also investigated by evaluating in vivo CYP1A1 activity using the zoxazolamine paralysis test. Results show that Hange-koboku-to, Dai-joki-to, and Magnoliae Cortex, which contain high levels of magnolol, significantly inhibited the clastogenesis induced by B(a)P and sufficiently inhibited in vivo CYP1A1 activity. In contrast, Goshakusan, which contains low levels of magnolol, had little inhibitory effect on clastogenicity and in vivo CYP1A1 activity. These findings suggest that magnolol is a major contributor to the inhibition of B(a)P-induced clastogenesis, and that kampo medicines exert significant anti-clastogenic effects.

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confidence: 99%

Anti-clastogenic Effect of Magnolol-Containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on Benzo(a)pyrene-Induced Clastogenicity in Mice

Saito

Fukushima

Nagase

2009

Biological & Pharmaceutical Bulletin

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“…To date, honokiol has been shown to exert many pharmacological effects, including anti-inflammatory, 36) anti-arrhythmic, 37) anxiolytic, 35) antitumor, 33) antithrombotic, 38) antiarthritic, 34) and anti-allergic 39) effects. However, the molecular targets underlying the numerous activities of honokiol have been poorly understood.…”

Section: Discussionmentioning

confidence: 99%

A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers

Kotani

Tanabe

Mizukami

et al. 2012

Biological & Pharmaceutical Bulletin

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We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated receptor (PPAR) γ/RXR, RXR/liver X receptor (LXR), and RXR/vitamin D receptor (VDR) heterodimers, whereas it effectively potentiated their activation by agonists for the partner NRs of the RXR heterodimers. These findings were further supported by increased mRNA and protein levels for the respective NR target genes. Bexarotene alone activated PPARγ/RXR and RXR/LXR heterodimers, but not RXR/VDR heterodimers, and facilitated the activation of all three RXR heterodimers by the respective PPARγ, LXR, and VDR agonists. When the potencies of honokiol and bexarotene were compared, honokiol was able to serve as a subsidiary agonist in the activation of RXR heterodimers in a similar manner to bexarotene. However, it seemed to potentiate the activation of PPARγ/RXR heterodimers by the PPARγ agonist rosiglitazone more efficiently than bexarotene, and was a less potent RXR agonist than bexarotene. In conclusion, we have demonstrated that honokiol is a rexinoid that possesses distinct properties from bexarotene, and mainly has subsidiary roles in the activation of RXR heterodimers by potentiating the activation of RXR heterodimers by agonists for the partner NRs.

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“…For example, the biphenyls magnolol and honokiol from the bark of Magnolia obovata have been shown to inhibit both the degranulation of rat mast cells (Ikarashi et al, 2001) and PCA reactions in mice (Han et al, 2007). Various stilbenes and their glycosides have displayed mast cell stabilising activity, including resveratrol (Han et al, 2013), gnetin H and…”

Section: Phenolsmentioning

confidence: 99%

Mast cell stabilisers

Zhang

Finn

Barlow

et al. 2016

European Journal of Pharmacology

108

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Magnolol and Honokiol: Inhibitors against Mouse Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors

Cited by 36 publications

References 19 publications

Anti-clastogenic Effect of Magnolol-Containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on Benzo(a)pyrene-Induced Clastogenicity in Mice

Anti-clastogenic Effect of Magnolol-Containing Hange-koboku-to, Dai-joki-to, Goshaku-san, and Magnoliae Cortex on Benzo(a)pyrene-Induced Clastogenicity in Mice

A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers

Mast cell stabilisers

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