Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice

Cheng, Jie; Dong, Shuqi; Yi, Long; Geng, Di; Liu, Qing

doi:10.1016/j.intimp.2018.03.031

Cited by 63 publications

(35 citation statements)

References 40 publications

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“…The activities of various hippocampal antioxidants like CAT, SOD, and GPx were considerably decreased with an increase in lipid peroxidation (MDA) were noted in CMS‐subjected rats. As mentioned before, chronic exposure of stress (CMS model) could leads to degeneration of neurons, hippocampus (atrophy‐increase lipid peroxidation) due to excessive activation of phagocytic cells (macrophages) which trigger excessive free radical generation (Cheng et al, ; Kumar & Mondal ) and hence the activities of antioxidant were decreased with increased MDA level. Whereas, rats injected with SB and IMP could significantly reverse the antioxidant activity and lipid peroxidation product to near normalcy because of its potent‐free radical scavenging (antioxidant) and anti‐lipid peroxidation activities (Jiang et at., ).…”

Section: Discussionmentioning

confidence: 99%

“…Ample amount of studies had reported that chronic psychological or physical stress could result in hyperactivity of HPA axis (HPA dysfunction) and eventually end up in the pathogenesis of depression which is indicated by hypersecretion of corticosteroid hormones like ACTH and CORT (Cheng, Dong, Yi, Geng, & Liu, ; Manthey et al, ). Hence, the levels of serum ACTH and CORT were evaluated to assess the effect of SB on the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

“…Where L1-L5 represent lane 1-5 of respective groups. CMS: chronic mild stress; SB: Salvianolic acid; IMP: imipramine; NLPR3: Nucleotide-binding domain, leucinerich repeat pyrin containing protein 3; ASC: associated adaptor speck proteins containing a CARD; Cleaved Casp-1: Cleaved Caspase-1 depression which is indicated by hypersecretion of corticosteroid hormones like ACTH and CORT (Cheng, Dong, Yi, Geng, & Liu, 2018;Manthey et al, 2011). Hence, the levels of serum ACTH and CORT were evaluated to assess the effect of SB on the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

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Salvianolic acid B abolished chronic mild stress‐induced depression through suppressing oxidative stress and neuro‐inflammation via regulating NLRP3 inflammasome activation

Huang

Wang

et al. 2018

J Food Biochem

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This study was framed to investigate the molecular mechanism behind the anti‐depressant effect of salvianolic acid B (SB) against unpredictable chronic mild stress (CMS) induced depression rat model. Control rats received only saline without CMS exposure, whereas CMS model rats were induced to several stress (CMS) for 6 weeks. Treatment group rats were induced with CMS for 6 weeks but received either 20 or 40 mg/kg of SB or 20 mg/kg imipramine (CMS+IMP) from the 4th week to 6th week. Treatment with SB or IMP significantly ameliorated body weight, sucrose consumption rate with shorter immobility time than the control group. Also, administration with SB or IMP could reverse the hyperactivity of hypothalamic‐pituitary‐adrenal axis as well as decreased inflammatory cytokines with improved antioxidant status. Furthermore, the protein expression of NLRP3 (inflammasome) was markedly downregulated upon treatment with SB (both 20 and 40 mg) or IMP and thereby confirming its potent anti‐depressant activity. Practical applications Salvianolic acid B (SB) is a phenolic acid extracted from Salvia militiorrhiza Bunge, a popular Chinese herb, which has been prescribed for various pathological conditions. SB has been previously reported with anti‐depressant activity but, the in‐depth mechanism behind the anti‐depressant effect of SB against CMS is still elusive. Hence, the current study was plotted to explore the in‐depth mechanism behind the anti‐depressant effect of SB against CMS model of depression in rats. The outcome of the current study has confirmed the anti‐depressant activity by abolishing oxidative stress, and neuroinflammatory response in the hippocampus through inhibiting NLRP3 inflammasome activation. Hence, SB can be prescribed to major depression patients with standard anti‐depressant agents to abolish oxidative stress, neuro‐inflammatory response, and related neurological changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Salvianolic acid B abolished chronic mild stress‐induced depression through suppressing oxidative stress and neuro‐inflammation via regulating NLRP3 inflammasome activation

Huang

Wang

et al. 2018

J Food Biochem

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“…Consequently, inhibition of neuroinflammation is crucial for the treatment of AD. MN has been reported to inhibit neuroinflammation in mice exhibiting depressive-like behaviors [45]. To confirm the impacts of MN on M1/M2 microglia polarization, we measured the levels of specific proinflammatory cytokines and anti-inflammatory mediators in the brains of TgCRND8 mice.…”

Section: Discussionmentioning

confidence: 99%

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

Xian

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by progressive memory loss. Magnolol (MN), the main active ingredient of Magnolia officinalis, possesses anti-AD effects in several experimental models of AD. In this study, we aimed to explore whether MN could ameliorate the cognitive deficits in TgCRND8 transgenic mice and to elucidate its molecular mechanisms. Male TgCRND8 mice were orally administered with MN (20 and 40 mg/kg) daily for 4 consecutive months, followed by assessing the spatial learning and memory functions using the open-field, radial arm maze, and novel object recognition tests. The results demonstrated that MN (20 and 40 mg/kg) could markedly ameliorate the cognitive deficits in TgCRND8 mice. In addition, MN significantly increased the expression of postsynaptic density protein 93 (PSD93), PSD-95, synapsin-1, synaptotagmin-1, synaptophysin (SYN), and interleukin-10 (IL-10), while markedly reduced the protein levels of tumor necrosis factor alpha (TNF-α), IL-6, IL-1β, Aβ40, and Aβ42, and modulated the amyloid precursor protein (APP) processing and phosphorylation. Immunofluorescence showed that MN significantly suppressed the activation of microglia (Iba-1) and astrocytes (GFAP) in the hippocampus and cerebral cortex of TgCRND8 mice. Mechanistic studies revealed that MN could significantly increase the ratios of p-GSK-3β (Ser9)/GSK-3β, p-Akt (Ser473)/Akt, and p-NF-κB p65/NF-κB p65. These findings indicate that MN exerted cognitive deficits improving effects via suppressing neuroinflammation, amyloid pathology, and synaptic dysfunction through regulating the PI3K/Akt/GSK-3β and NF-κB pathways, suggesting that MN is a promising naturally occurring polyphenol worthy of further developing into a therapeutic agent for AD treatment.

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“…Os iridoides são uma classe de metabólitos secundários que tem recebido atenção da comunidade científica devido aos seus pronunciados efeitos farmacológicos em modelos animais, quanto às atividades hipolipidêmica, antiviral, antibacteriano, hipoglicêmico, antiinflamatório e antidepressivo (CHENG et al, 2018;HUSSAIN et al, 2018;PANKOKE et al, 2013;ZHOU et al, 2016). Dentre eles, o plumierídeo têm sido estudados por nosso grupo de pesquisa devido aos efeitos tipo-antidepressivo e anti-inflamatório após baixas doses administradas aos camundongos (BONOMINI et al, 2017;SILVA, 2007).…”

Section: Introductionunclassified

Avaliação de efeitos preliminares do plumierídeo após administração oral a camundongos

Dalmagro

Camargo

Zimath

et al. 2019

BJHR

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Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice

Cited by 63 publications

References 40 publications

Salvianolic acid B abolished chronic mild stress‐induced depression through suppressing oxidative stress and neuro‐inflammation via regulating NLRP3 inflammasome activation

Salvianolic acid B abolished chronic mild stress‐induced depression through suppressing oxidative stress and neuro‐inflammation via regulating NLRP3 inflammasome activation

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

Avaliação de efeitos preliminares do plumierídeo após administração oral a camundongos

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