Avaliação de efeitos preliminares do plumierídeo após administração oral a camundongos

Dalmagro, Ana Paula; Camargo, Anderson; Zimath, Priscila Laiz; Bonomini, Tiago José; Zeni, Ana Lúcia Bertarello; Malheiros, Ângela; Souza, Márcia María de

doi:10.34119/bjhrv2n6-067

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…), 1 h before the behavioral tests. The dose of PLU used in this research was determined according to previous experiments (Bonomini et al 2017;Dalmagro 2019;Dalmagro et al 2019).…”

Section: Drugs and Treatmentsmentioning

confidence: 99%

Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Dalmagro

Camargo

Zimath

et al. 2020

Natural Product Research

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Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pretreated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABA A , GABA B , 5-HT 1A , 5-HT 3 , α 1 , α 2 , and D 2 receptors.

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“…), 1 h before the behavioral tests. The dose of PLU used in this research was determined according to previous experiments (Bonomini et al 2017;Dalmagro 2019;Dalmagro et al 2019).…”

Section: Drugs and Treatmentsmentioning

confidence: 99%

Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Dalmagro

Camargo

Zimath

et al. 2020

Natural Product Research

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“…The antinociceptive, anti-inflammatory, hepatoprotective, and immunostimulatory effects are already attributed to PLU (BOEING et al, 2018;SINGH et al, 2014;SINGH et al, 2017). Also, plumieride did not interfere with the locomotor capacity of mice after acute administration and did not exert anticonvulsant effect (DALMAGRO et al, 2019).…”

Section: Introductionmentioning

confidence: 96%

Modulation of nitro-oxidative parameters in mice administered with very low doses of the iridoid plumieride

Dalmagro

Camargo

Zimath

et al. 2020

BJHR

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ABCTRACT Key words: Plumieride; iridoid; Allamanda cathartica; oxidative stress. RESUMONosso grupo de pesquisa tem investigado os efeitos anti-inflamatório e tipo-antidepressivo do plumierídeo (PLU -0,5, 1 e 2 µg/Kg). Contudo, não há evidências na literatura científica quanto a atividade antioxidante do PLU quando usado em doses extremamente baixas, que podem ser relacionados aos seus efeitos farmacológicos. Neste estudo, foi administrado PLU (0,5, 1 e 2 µg/Kg) à camundongos durante 7 dias. Posteriormente, nós avaliados a capacidade do PLU em modular a lipoperoxidação, nitritos, carbonilação de proteínas e tióis não-proteicos no cérebro, plasma, fígado e rins dos camundongos. Nossos resultados fundamentam, pelo menos em parte, o potencial farmacológico que tem sido atribuído ao iridoide.Palavras-chave: Plumierídeo; iridoide; Allamanda cathartica; estresse oxidativo.

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Avaliação de efeitos preliminares do plumierídeo após administração oral a camundongos

Cited by 2 publications

References 21 publications

Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Modulation of nitro-oxidative parameters in mice administered with very low doses of the iridoid plumieride

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