Magnitude and Impact of Diarrheal Diseases

Guerrant, Richard L.; Kosek, Margaret; Moore, Sean R.; Lorntz, Breyette; Brantley, Richard K.; Lima, Aldo A. M.

doi:10.1016/s0188-4409(02)00379-x

Cited by 142 publications

(84 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Acute diarrhoeal disease (ADD) is a serious public health problem in developing countries, and it remains a major cause of morbidity and mortality in children younger than five years of age [1]. In this age group it is estimated that 1.5 to 2.5 million deaths occur annually due to ADD, that is, about 10 deaths every minute [2,3].…”

Section: Introductionmentioning

confidence: 99%

Enterotoxigenic Escherichia coli associated with childhood diarrhoea in Colombia, South America

Gómez‐Duarte

Romero-Herazo

Páez-Canro

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Intestinal Escherichia coli pathogens are major causes of diarrhoeal disease in children under five years of age worldwide. The aim of this study is to evaluate the association of E. coli pathotypes with childhood diarrhoea in Colombia. Methodology: A case-control study was conducted in 815 samples from children younger than five years of age in Cartagena, Colombia (466 cases and 349 controls). Controls were randomly selected 1:1 to cases, to obtain 349 cases and 349 controls. Results: This study revealed that 27 (7.44%) cases and 12 (3.43%) controls were positives for any of the E. coli pathotypes. The difference observed was statistically significant indicating that E. coli pathotypes were associated with cases of childhood diarrhoea. Enterotoxigenic E. coli (ETEC) was the most common pathotype associated with childhood diarrhoea. Additional E. coli pathotypes were also identified. Conclusions: We conclude that after the adjustment by age, sex and socioeconomic stratum, the odds ratio obtained by logistic regression shows an association between infection with ETEC and childhood diarrhoea.

show abstract

Section: Introductionmentioning

confidence: 99%

Enterotoxigenic Escherichia coli associated with childhood diarrhoea in Colombia, South America

Gómez‐Duarte

Romero-Herazo

Páez-Canro

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…adenylyl cyclase ͉ cGMP ͉ guanylyl cyclase ͉ cAMP ͉ toxin-induced diarrhea D iarrhea is one of the principal causes of mortality in children in the developing world, being responsible for 2.5 million deaths per year (1,2), and about 60% of these deaths are caused by enterotoxigenic strains of bacteria, including Escherichia coli (3). One of the toxins, heat-stable enterotoxin (STa), binds to intestinal epithelial cell membrane receptor, guanylyl cyclase type C (GC-C), and activates the enzyme to increase the synthesis of cyclic guanosine 3Ј,5Ј-monophosphate (cGMP) (4)(5)(6).…”

mentioning

confidence: 99%

Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea

Kots¹,

Choi²,

Estrella-Jimenez

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

show abstract

“…As doenças transmitidas por alimentos (DTA) são, ainda, um importante problema de saúde pública no mundo contemporâneo [1][2][3] .…”

Section: N T R O D U ç ã Ounclassified

Desenvolvimento e reprodutibilidade de questionário para avaliar práticas e conhecimentos em segurança alimentar de nutricionistas da área clínica

2007

View full text Add to dashboard Cite

OBJETIVO: Os propósitos deste estudo foram desenvolver um questionário para avaliar práticas e conhecimentos em segurança sanitária alimentar, de nutricionistas da área clínica, e medir o nível de reprodutibilidade deste questionário. MÉTODOS: O questionário foi desenvolvido a partir de seis áreas temáticas: prevenção da contaminação cruzada; higiene pessoal/ambiental; controle de temperaturas e de alimentos de alto risco e segurança alimentar para indivíduos portadores do vírus da imunodeficiência humana/síndrome da imunodeficiência adquirida. Para medir o nível de reprodutibilidade, utilizou-se o procedimento de teste e re-teste e a estatística kappa simples. RESULTADOS: Os resultados mostraram os níveis de reprodutibilidade: >0,61 para 95,0%; entre 0,60-0,40 para 2,5% e <0,40 para 2,5% das questões testadas. Oitenta por cento das questões apresentaram grau de acertos na faixa de 20,0%-80,0%. CONCLUSÃO: Os resultados mostraram que o instrumento apresenta grau de dificuldade adequado e um nível de reprodutibilidade satisfatório para a maioria das questões (Kappa>0,61), sugerindo que o mesmo representa uma boa opção para avaliar as práticas e os conhecimentos em segurança alimentar de nutricionistas da área clínica, visando ao planejamento de estratégias educativas.

show abstract

Magnitude and Impact of Diarrheal Diseases

Cited by 142 publications

References 28 publications

Enterotoxigenic Escherichia coli associated with childhood diarrhoea in Colombia, South America

Enterotoxigenic Escherichia coli associated with childhood diarrhoea in Colombia, South America

Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea

Desenvolvimento e reprodutibilidade de questionário para avaliar práticas e conhecimentos em segurança alimentar de nutricionistas da área clínica

Contact Info

Product

Resources

About