MagNI: A Magnetoelectrically Powered and Controlled Wireless Neurostimulating Implant

Yu, Zhanghao; Chen, Joshua; Alrashdan, Fatima T.; Avants, Benjamin W.; He, Yan; Singer, Amanda; Robinson, Jacob T.; Yang, Kaiyuan

doi:10.1109/tbcas.2020.3037862

Cited by 42 publications

(44 citation statements)

References 50 publications

(77 reference statements)

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“…Magnetoelectrics combined with a custom ASIC enables a millimeter-sized neural stimulator: To overcome the challenge of wireless data and power delivery to miniature bioelectronic implants, we developed a data and power delivery system based on magnetoelectrics, which achieves high power densities within the safety limits for human exposure [36]. Magnetoelectric materials provide efficient power delivery for bioelectronic implants by directly converting magnetic fields to electric fields based on the material properties [35,37].…”

Section: Resultsmentioning

confidence: 99%

“…When we apply a magnetic field to the material, the magnetostrictive material generates a strain that is coupled to the piezoelectric layer that, in turn, generates an electric field [35]. Thus, by applying an alternating magnetic field at the acoustic resonant frequency of the film we can efficiently deliver power to our implant [35,36,38, 39]. In addition to delivering power, we can also transmit data to our implant by modulating the frequency of the applied magnetic field.…”

Section: Resultsmentioning

confidence: 99%

“…As a result, it has been shown that ME demonstrates more stable power transfer as a function of angular misalignment. [36]. This angular stability is supplemented by the fact that the large magnetic permeability of the Metglas layer helps to concentrate the magnetic field lines along the length of the ME film [41].…”

Section: Resultsmentioning

confidence: 99%

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Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Chen

Kan

et al. 2021

Preprint

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Implanted bioelectronic devices have the potential to treat disorders that are resistant to traditional pharmacological therapies; however, reaching many therapeutic nerve targets requires invasive surgeries and implantation of centimeter-sized devices. Here we show that it is possible to stimulate peripheral nerves from within blood vessels using a millimeter-sized wireless implant. By directing the stimulating leads through the blood vessels we can target specific nerves that are difficult to reach with traditional surgeries. Furthermore, we demonstrate this endovascular nerve stimulation (EVNS) with a millimeter sized wireless stimulator that can be delivered minimally invasively through a percutaneous catheter which would significantly lower the barrier to entry for neuromodulatory treatment approaches because of the reduced risk. This miniaturization is achieved by using magnetoelectric materials to efficiently deliver data and power through tissue to a digitally-programmable 0.8 mm2 CMOS system-on-a-chip. As a proof-of-principle we show wireless stimulation of peripheral nerve targets both directly and from within the blood vessels in rodent and porcine models. The wireless EVNS concept described here provides a path toward minimally invasive bioelectronics where mm-sized implants combined with endovascular stimulation enable access to a number of nerve targets without open surgery or implantation of battery-powered pulse generators.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Chen

Kan

et al. 2021

Preprint

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“…Such a set of conversions resolves the reflection issue of ultrasound and alleviates the miniaturization difficulty of inductive (Singer et al, 2020;Yu et al, 2020b). Nevertheless, ME composite is hard to fabricate, and the composite's low energy conversion ratio is a hurdle to overcome (Truong, 2020;Yu et al, 2020a).…”

Section: Wireless Power Transfer For Miniaturized Implantable Devicesmentioning

confidence: 99%

Energy-Efficient Integrated Circuit Solutions Toward Miniaturized Closed-Loop Neural Interface Systems

et al. 2021

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Miniaturized implantable devices play a crucial role in neural interfaces by monitoring and modulating neural activities on the peripheral and central nervous systems. Research efforts toward a compact wireless closed-loop system stimulating the nerve automatically according to the user's condition have been maintained. These systems have several advantages over open-loop stimulation systems such as reduction in both power consumption and side effects of continuous stimulation. Furthermore, a compact and wireless device consuming low energy alleviates foreign body reactions and risk of frequent surgical operations. Unfortunately, however, the miniaturized closed-loop neural interface system induces several hardware design challenges such as neural activity recording with severe stimulation artifact, real-time stimulation artifact removal, and energy-efficient wireless power delivery. Here, we will review recent approaches toward the miniaturized closed-loop neural interface system with integrated circuit (IC) techniques.

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Section: Introductionmentioning

confidence: 99%

Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics

Singer

Robinson

2021

Adv Healthcare Materials

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Progress in implanted bioelectronic technology offers the opportunity to develop more effective tools for personalized electronic medicine. While there are numerous clinical and pre‐clinical applications for these devices, power delivery to these systems can be challenging. Wireless battery‐free devices offer advantages such as a smaller and lighter device footprint and reduced failures and infections by eliminating lead wires. However, with the development of wireless technologies, there are fundamental tradeoffs between five essential factors: power, miniaturization, depth, alignment tolerance, and transmitter distance, while still allowing devices to work within safety limits. These tradeoffs mean that multiple forms of wireless power transfer are necessary for different devices to best meet the needs for a given biological target. Here six different types of wireless power transfer technologies used in bioelectronic implants—inductive coupling, radio frequency, mid‐field, ultrasound, magnetoelectrics, and light—are reviewed in context of the five tradeoffs listed above. This core group of wireless power modalities is then used to suggest possible future bioelectronic technologies and their biological applications.

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MagNI: A Magnetoelectrically Powered and Controlled Wireless Neurostimulating Implant

Cited by 42 publications

References 50 publications

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Energy-Efficient Integrated Circuit Solutions Toward Miniaturized Closed-Loop Neural Interface Systems

Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics

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