Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells

Abstract

Nanoreactors, in which the reactions are remotely controlled by magnetic fields, are potentially valuable in bioorthogonal chemistry for future applications. Here, we develop a silica-confined magnetothermia-induced nanoreactor (MAG-NER) by selectively growing Pd nanocrystals on a preinstalled ironoxide core inside a hollow silica nanoshell. The growth is achieved by magnetic induction. The interfacial catalytic site is activated by stimulating localized magnetothermia, and nanocompartmentalization is realized by the size-selective porous silica. Therefore, MAG-NER can be conveniently used in complex biomedia and can even be internalized to living cells, realizing an on-demand, high-performance intramolecular carbocyclization reaction by remote operation without compromising the cell viability. This work opens avenues for the design of advanced nanoreactors that complement and augment the existing bioorthogonal chemical tools.

Magnetic–Plasmonic Multimodular Hollow Nanoreactors for Compartmentalized Orthogonal Tandem Catalysis

“…This design challenge requires the integration of optimal molecular diffusion to and from active sites as well as switching the selected step “on” and “off” in situ by a benign and site-selective energy flow, tightly controlling different products while suppressing side reactions. − Such a compartmentalized energy supply can facilitate the arbitrary integration of steps from a diverse pool of catalytic reactions, facilitating a one-pot total synthesis irrespective of the thermodynamic compatibility. In addition, while they avoid the nonspecific heating of the bulk reaction, these systems would be adoptable for specific applications involving heat-sensitive media such as in locally synthesizing desired molecular probes or therapeutic molecules in a delicate bioenvironment, functioning on-demand with in-built stimuli-responsive plugins. − Unfortunately, commonly synthesized hybrid magnetic–plasmonic nanostructures such as core–shells, yolk shells, and heterodimers are unsuitable for these purpose-directed applications, in which the independent but synchronous operation of magnetic and plasmonic components is required. − In this study, we propose a suitable multimodular catalytic platform comprising nanocompartmentalized antennae-reactor components that can efficiently receive and supply hyperlocal energy to a specific reaction site without an interconflicting mechanism. To achieve this, we integrated “plasmonic–catalytic” and “magnetic–catalytic” components in an isolated but tethered configuration that independently recruits near-infrared light (NIR) and an alternating magnetic field (AMF), respectively, as selective excitation modules on the distinct energy spectrum.…”

New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats

“…After storing for one year, particle size and size distribution were not obvious changed. strategies used to obtain the nanoparticles, the anti-solvent precipitation method has been explored, and it is easily commercialized with a relatively cheap cost to scale up production [25][26][27][28][29].…”

“…The pharmaceutical excipients are often used as stabilizers, such as hydroxypropyl methylcellulose (HPMC) [19], hydroxypropylcellulose (HPC) [20], polyvinyl pyrrolidone (PVPK30) [21], polysorbate (Tween 80) [22], and sodium dodecyl sulfate (SDS) [23,24]. Among the strategies used to obtain the nanoparticles, the anti-solvent precipitation method has been explored, and it is easily commercialized with a relatively cheap cost to scale up production [25][26][27][28][29].…”

Critical Review on Synthetic Routes and Catalytic Applications of Hollow Nanomaterials

“…[92] Nucleation sites results when amino groups interact with Pt nanoparticles and attached to silica surface. [93] These nucleation sites promote growth of platinum. Surfactants assist the attribution of nanosponge shell followed by 3-days etching process with 10% aqueous HF at room temperature.…”