Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

Huang, Pin‐Chieh; Chaney, Eric J.; Shelton, Ryan L.; Boppart, Stephen A.

doi:10.1109/tbme.2018.2819649

Cited by 9 publications

(6 citation statements)

References 66 publications

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“…Theranostic functionality enabled by a combination of MNP-based treatments and the MM imaging modalities has been of research interest in recent years, as demonstrated for hearing augmentation 74 and MH dosimetry 34 , 75 . This work presents the first in vivo oncology application of a MM-imaging enabled theranostic platform.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

et al. 2021

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Rationale: Magnetic nanoparticle hyperthermia (MH) therapy is capable of thermally damaging tumor cells, yet a biomechanically-sensitive monitoring method for the applied thermal dosage has not been established. Biomechanical changes to tissue are known indicators for tumor diagnosis due to its association with the structural organization and composition of tissues at the cellular and molecular level. Here, by exploiting the theranostic functionality of magnetic nanoparticles (MNPs), we aim to explore the potential of using stiffness-based metrics that reveal the intrinsic biophysical changes of in vivo melanoma tumors after MH therapy. Methods: A total of 14 melanoma-bearing mice were intratumorally injected with dextran-coated MNPs, enabling MH treatment upon the application of an alternating magnetic field (AMF) at 64.7 kHz. The presence of the MNP heating sources was detected by magnetomotive optical coherence tomography (MM-OCT). For the first time, the elasticity alterations of the hyperthermia-treated, MNP-laden, in vivo tumors were also measured with magnetomotive optical coherence elastography (MM-OCE), based on the mechanical resonant frequency detected. To investigate the correlation between stiffness changes and the intrinsic biological changes, histopathology was performed on the excised tumor after the in vivo measurements. Results: Distinct shifts in mechanical resonant frequency were observed only in the MH-treated group, suggesting a heat-induced stiffness change in the melanoma tumor. Moreover, tumor cellularity, protein conformation, and temperature rise all play a role in tumor stiffness changes after MH treatment. With low cellularity, tumor softens after MH even with low temperature elevation. In contrast, with high cellularity, tumor softening occurs only with a low temperature rise, which is potentially due to protein unfolding, whereas tumor stiffening was seen with a higher temperature rise, likely due to protein denaturation. Conclusions: This study exploits the theranostic functionality of MNPs and investigates the MH-induced stiffness change on in vivo melanoma-bearing mice with MM-OCT and MM-OCE for the first time. It was discovered that the elasticity alteration of the melanoma tumor after MH treatment depends on both thermal dosage and the morphological features of the tumor. In summary, changes in tissue-level elasticity can potentially be a physically and physiologically meaningful metric and integrative therapeutic marker for MH treatment, while MM-OCE can be a suitable dosimetry technique.

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Section: Discussionmentioning

confidence: 99%

Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

et al. 2021

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“…The system was operated at an ∼92 kHz line-scan rate and had a resolution of ∼8 and ∼20 μm in axial and transverse directions, respectively. More details on OCT system can be found from an earlier publication . The cross-sectional biofilm images were preprocessed for orientation corrections using Fiji version 2.00 .…”

Section: Methodsmentioning

confidence: 99%

“…More details on OCT system can be found from an earlier publication. 42 The cross-sectional biofilm images were preprocessed for orientation corrections using Fiji version 2.00. 43 Approximately 100−180 frames in the middle of the stack were selected for the overall biofilm structural characterization (eq 2).…”

Section: ■ Methodsmentioning

confidence: 99%

Effect of Nonphosphorus Corrosion Inhibitors on Biofilm Pore Structure and Mechanical Properties

Huang

Sun

Won

et al. 2020

Environ. Sci. Technol.

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Understanding the effects of biofilm structural and mechanical properties, which can influence biofilm cohesiveness and detachment under physical stress, is critical for biofilm and biofilm-associated pathogen control. In this study, we used optical coherence tomography (OCT) and nanoindentation to determine the role of silicate and tin (two experimental nonphosphate corrosion inhibitors) on the porous structure and stiffness of three types of multispecies biofilms. These biofilms were grown from groundwater (a drinking water source), and this groundwater was amended with either tin or silicate corrosion inhibitor (0.5 mg/L as Sn and 20 mg/L as SiO2). Based on the elastic moduli of these biofilms, tin biofilms and groundwater biofilms were the stiffest, followed by silicate biofilms. The thickness normalized by the growth time for silicate biofilms was highest at 38 ± 7.1 μm/month, compared to 21 ± 3.2 and 11 ± 2.4 μm/month for tin biofilms and groundwater biofilms, respectively. The silicate biofilms had the greatest overall porosities and were thickest among the three biofilms. Based on the pore network modeling (PNM) of OCT images, larger pores and connections were found in the silicate biofilms compared to those in tin and groundwater biofilms. Our analysis showed that the thicker and more porous biofilms (silicate biofilms) were potentially less resistant to deformation than the thinner and denser biofilms (tin and groundwater biofilms).

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“…Outside of applications in guiding drug delivery or cancer therapy, magneto-motive displacement was applied at the tympanic membrane to enhance sound perception 182 . Application of iron oxide nanoparticles at the rat tympanic membrane (TM), ex vivo , caused increased vibration of the TM upon exposure to an alternating magnetic field.…”

Section: Future Outlook Of Magneto-motive Imaging Modalitiesmentioning

confidence: 99%

Magnetic particles in motion: magneto-motive imaging and sensing

Kubelick¹,

Mehrmohammadi²

2022

Theranostics

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Superparamagnetic nanoparticles have become an important tool in biomedicine. Their biocompatibility, controllable small size, and magnetic properties allow manipulation with an external magnetic field for a variety of diagnostic and therapeutic applications. Recently, the magnetically-induced motion of superparamagnetic nanoparticles has been investigated as a new source of imaging contrast. In magneto-motive imaging, an external, time-varying magnetic field is applied to move a magnetically labeled subject, such as labeled cells or tissue. Several major imaging modalities such as ultrasound, photoacoustic imaging, optical coherence tomography, and laser speckle tracking can utilize magneto-motive contrast to monitor biological events at smaller scales with enhanced contrast and sensitivity. In this review article, an overview of magneto-motive imaging techniques is presented, including synthesis of superparamagnetic nanoparticles, fundamental principles of magneto-motive force and its utility to excite labeled tissue within a viscoelastic medium, current capabilities of magneto-motive imaging modalities, and a discussion of the challenges and future outlook in the magneto-motive imaging domain.

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Magnetomotive Displacement of the Tympanic Membrane Using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

Cited by 9 publications

References 66 publications

Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

Effect of Nonphosphorus Corrosion Inhibitors on Biofilm Pore Structure and Mechanical Properties

Magnetic particles in motion: magneto-motive imaging and sensing

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