Magnetic particles in motion: magneto-motive imaging and sensing

Kubelick, Kelsey P.; Mehrmohammadi, Mohammad

doi:10.7150/thno.54056

Cited by 13 publications

(6 citation statements)

References 170 publications

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“…Unlike MRI, MPI can specifically quantify the amount of SPIO-labeled MSCs post administration 105 , 106 . MMUS can also use SPIO as an imaging agent 107 , and hence has potential to detect SPIO-labeled MSCs as well. Finally, therapeutic NPs can be labeled with SPECT or PET tracers, but to the best of our knowledge no theranostic studies have been performed yet with NP-labeled MSCs.…”

Section: Imaging Modalities For Cellular Nanotheranosticsmentioning

confidence: 99%

Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics

Rosu,

Ghaemi,

Bulte

et al. 2024

Theranostics

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Various classes of nanotheranostics have been developed for enhanced tumor imaging and therapy. However, key limitations for a successful use of nanotheranostics include their targeting specificity with limited off-site tissue accumulation as well as their distribution and prolonged retention throughout the entire tumor. Due to their inherent tumor-tropic properties, the use of mesenchymal stem cells (MSCs) as a “Trojan horse” has recently been proposed to deliver nanotheranostics more effectively. This review discusses the current status of “cellular nanotheranostics” for combined (multimodal) imaging and therapy in preclinical cancer models. Emphasis is placed on the limited knowledge of the signaling pathways and molecular mechanisms of MSC tumor-tropism, and how such information may be exploited to engineer MSCs in order to further improve tumor homing and nanotheranostic delivery using image-guided procedures.

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Section: Imaging Modalities For Cellular Nanotheranosticsmentioning

confidence: 99%

Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics

Rosu,

Ghaemi,

Bulte

et al. 2024

Theranostics

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“…Magnetic nanoparticles or nanorobots, particularly, the Fe-based one, can be driven by an external magnetic field (e.g., an alternating magnetic field (AMF)) to achieve their localized accumulation and/or generate magnetic hyperthermia. In this procedure, magnetic particle-assisted imaging or T2WI MRI as well as the magnetothermal effect-triggered cargo release from the nanomedicine can be realized 61 , 62 .…”

Section: Stimuli-activatable Strategies For Nanomedicine-assisted Can...mentioning

confidence: 99%

Stimuli-activatable nanomedicine meets cancer theranostics

Li,

Feng,

Luo

et al. 2023

Theranostics

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Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics. Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable nanomedicine could be self-assembled, disassembled, or functionally activated to improve its biosafety and diagnostic/therapeutic potency. A myriad of tumor-specific features, including a low pH, a high redox level, and overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, and radiation) have been considered for the design of stimuli-activatable nano-medicinal products. Recently, novel stimuli sources have been explored and elegant designs emerged for stimuli-activatable nanomedicine. In addition, multi-functional theranostic nanomedicine has been employed for imaging-guided or image-assisted antitumor therapy. In this review, we rationalize the development of theranostic nanomedicine for clinical pressing needs. Stimuli-activatable self-assembly, disassembly or functional activation approaches for developing theranostic nanomedicine to realize a better diagnostic/therapeutic efficacy are elaborated and state-of-the-art advances in their structural designs are detailed. A reflection, clinical status, and future perspectives in the stimuli-activatable nanomedicine are provided.

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“…As for clinical applications, MMUS may become a useful tool for preoperative examination and surgical guidance without such limitations as radioisotope exposure or low penetration depth of light-based imaging systems. However, some necessary technical developments are still needed [ 103 , 108 ]. Nevertheless, the MMUS technique has some limitations, such as a poor signal-to-noise ratio, a comparatively low spatiotemporal resolution, and can be improved by using magneto-gas vesicles (MGVs) as alternative contrast agents [ 109 ].…”

Section: Practical Applications Of Magneto-mechanical Actuationsmentioning

confidence: 99%

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

Никитин

Ivanova

Semkina

et al. 2022

IJMS

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The magneto-mechanical approach is a powerful technique used in many different applications in biomedicine, including remote control enzyme activity, cell receptors, cancer-selective treatments, mechanically-activated drug releases, etc. This approach is based on the use of a combination of magnetic nanoparticles and external magnetic fields that have led to the movement of such nanoparticles with torques and forces (enough to change the conformation of biomolecules or even break weak chemical bonds). However, despite many theoretical and experimental works on this topic, it is difficult to predict the magneto-mechanical effects in each particular case, while the important results are scattered and often cannot be translated to other experiments. The main reason is that the magneto-mechanical effect is extremely sensitive to changes in any parameter of magnetic nanoparticles and the environment and changes in the parameters of the applied magnetic field. Thus, in this review, we (1) summarize and propose a simplified theoretical explanation of the main factors affecting the efficiency of the magneto-mechanical approach; (2) discuss the nature of the MNP-mediated mechanical forces and their order of magnitude; (3) show some of the main applications of the magneto-mechanical approach in the control over the properties of biological systems.

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Magnetic particles in motion: magneto-motive imaging and sensing

Cited by 13 publications

References 170 publications

Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics

Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics

Stimuli-activatable nanomedicine meets cancer theranostics

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

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