Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy

Lin, Yung Yang; Shih, Yang Hsin; Hsieh, Jen Chuen; Yu, Hsiang‐Yu; Yiu, Chun Hing; Wong, Tai-Tong; Yeh, Ta‐Chuan; Kwan, S. Y.; Ho, ­Low‐Tone; Yen, Der Jen; Wu, Zin-An; Chang, Mau Song

doi:10.1016/s1053-8119(03)00181-2

Cited by 69 publications

(42 citation statements)

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“…Tangential spikes can be detected by scalp EEG if the source is large enough to overcome the background brain noise. This may be why the ECD moment of the E/M-spikes was sometimes larger than that of the M-spikes in the present study as well as in a previous report (Lin et al 2003). Fig.…”

Section: Discussionsupporting

confidence: 77%

“…The present and previous reports (Iwasaki et al 2002b;Park et al 2002;Zijlmans et al 2002;Lin et al 2003) show that M-spikes are Note that the E/M-spike has significantly larger ECD moment than the M-spikes but the localizations are very similar (Fig. 3).…”

Section: Discussionsupporting

confidence: 77%

“…However, the present study was designed to compare ECD parameters between E/M-spikes and M-spikes, not the spike detectability between EEG and MEG. The international 10-20 electrode system is typical for current routine clinical simultaneous measurement of EEG and MEG (Stefan et al 1992;Iwasaki et al 2002a;Park et al 2002;Yoshinaga et al 2002;Zijlmans et al 2002;Lin et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, scalp EEG detects both tangential and radial components of a current source in a spherical volume conductor, whereas MEG detects only the tangential components (Cohen and Cuffin 1983;Hämäläinen et al 1993). However, MEG has detected a large number of epileptic discharges without concurrent activity in conventional scalp EEG in patients with temporal lobe (Knowlton et al 1997;Iwasaki et al 2002b;Zijlmans et al 2002;Iwasaki et al 2003;Lin et al 2003) and extratemporal lobe (Knowlton et al 1997;Park et al 2002;Yoshinaga et al 2002) epilepsy. Therefore, the sensitivity of MEG and EEG for the detection of epileptic discharges does not depend only on source orientation.…”

mentioning

confidence: 99%

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Comparison of Magnetoencephalographic Spikes with and without Concurrent Electroencephalographic Spikes in Extratemporal Epilepsy

Park

Nakasato

Iwasaki

et al. 2004

Tohoku J. Exp. Med.

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Interictal spikes in patients with epilepsy may be detected by either electroencephalography (EEG) (E-spikes) or magnetoencephalography (MEG) (M-spikes), or both MEG and EEG (E/M-spikes). Localization and amplitude were compared between E/M-spikes and M-spikes in 7 adult patients with extratemporal epilepsy to evaluate the clinical significance of MEG spikes. MEG and EEG were simultaneously measured using a helmet-shaped MEG system with planar-type gradiometers and scalp electrodes of the international 10-20 system. Sources of E/M-spikes and M-spikes were estimated by an equivalent current dipole (ECD) model for MEG at peak latency. Each subject showed 9 to 20 (mean 13.4) E/M-spikes and 9 to 31 (mean 16.3) M-spikes. No subjects showed significant differences in the ECD locations between E/M-and M-spikes. ECD moments of the E/M-spikes were significantly larger in 2 patients and not significantly different in the other 5 patients. The similar localizations of E/M-spikes and M-spikes suggest that combination of MEG and EEG is useful to detect more interictal spikes in patients with extratemporal epilepsy. The smaller tendency of ECD amplitude of the M-spikes than E/M-spikes suggests that scalp EEG may overlook small tangential spikes due to background brain noise. Localization value of M-spikes is clinically equivalent to that of E/M-spikes. magnetoencephalography; electroencephalography; epilepsy; interictal spike; equivalent current dipole

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Comparison of Magnetoencephalographic Spikes with and without Concurrent Electroencephalographic Spikes in Extratemporal Epilepsy

Park

Nakasato

Iwasaki

et al. 2004

Tohoku J. Exp. Med.

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“…Although we are not generally recording simultaneous EEG, literature indicates that these concurrent data may be valuable in the adult population with epilepsy 18,34,35 and potentially in the pediatric population. 29,36 We plan to add this to our routine practice shortly, though determination of tolerance by pediatric patients remains to be established.…”

Section: Techniquementioning

confidence: 99%

Magnetoencephalography for Pediatric Epilepsy: How We Do It

Schwartz¹,

Dlugos²,

Storm³

et al. 2008

AJNR Am J Neuroradiol

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SUMMARY: Magnetoencephalography (MEG) is increasingly being used in the preoperative evaluation of pediatric patients with epilepsy. The ability to noninvasively localize ictal onset zones (IOZ) and their relationships to eloquent functional cortex allows the pediatric epilepsy team to more accurately assess the likelihood of postoperative seizure freedom, while more precisely prognosticating the potential functional deficits that may be expected from resective surgery. Confirmation of clinically suggested multifocality may result in a recommendation against resective surgery because the probability of seizure freedom will be low. Current paradigms for motor and somatosensory testing are robust. Paradigms allowing localization of those regions necessary for competent language function, though promising, are under continuous optimization. MR imaging white matter trajectory data, created from diffusion tensor imaging obtained in the same setting as the localization brain MR imaging, provide ancillary information regarding connectivity of the IOZ to sites of rapid secondary spread and the spatial relationship of the IOZ to functionally important white matter bundles, such as the corticospinal tracts. A collaborative effort between neuroradiology, neurology, neurosurgery, neuropsychology, technology, and physics ensures successful implementation of MEG within a pediatric epilepsy program.

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Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice

Mathieu

Remmelink

D’Haene

et al. 2004

Cancer

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BACKGROUNDNonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of a very large set of endogenous proteins, which antagonize chemotherapy‐mediated attacks on these tumor cells.METHODSThe authors set up an orthotopic model of a human NSCLC by grafting A549 cells into the lungs of nude mice. They tried treating these A549 NSCLC orthotopic xenograft–bearing nude mice on the basis of various chemotherapeutic protocols, including chronic administrations of taxol, oxaliplatin, and irinotecan. A cyclooxygenase‐2 (COX‐2) inhibitor (NS‐398) also was assayed in combination with taxol. The immunohistochemical expression levels of COX‐2, prostaglandin E synthetase (PGES), ornithine decarboxylase (ODC), the lung‐related resistance protein (LRP), and glutathione‐S‐transferase‐α (GST‐α), GST‐μ, and GST‐π were quantitatively determined by means of computer‐assisted microscopy in control and drug‐treated NSCLC orthotopic xenografts.RESULTSThe orthotopic A549 xenograft model developed in 100% of the grafted mice, leading to brain metastases in approximately 61% mice and to liver metastases in approximately 40% of mice. The model was resistant to taxol and oxaliplatin and was only weakly sensitive to irinotecan. High levels of chemoresistant markers (i.e., COX‐2, PGES, ODC, LRP, GST‐α, GST‐μ, and GST‐π) were observed in the nontreated A549 xenografts, although with dramatic variations in individual expression. Taxol and oxaliplatin significantly increased the levels of expression of COX‐2, PGES, GST‐μ, and GST‐π in a number of different experimental protocols.CONCLUSIONSThe A549 orthotopic xenograft model could be used to evaluate investigational chemotherapeutic agents to identify drugs rapidly that are more active than the drugs currently in use in hospitals. Cancer 2004. © 2004 American Cancer Society.

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Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy

Cited by 69 publications

References 50 publications

Comparison of Magnetoencephalographic Spikes with and without Concurrent Electroencephalographic Spikes in Extratemporal Epilepsy

Comparison of Magnetoencephalographic Spikes with and without Concurrent Electroencephalographic Spikes in Extratemporal Epilepsy

Magnetoencephalography for Pediatric Epilepsy: How We Do It

Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice

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