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REPORT DATE
July 2013
REPORT TYPE
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERCincinnati Children's Hospital Medical Center Cincinnati, OH 45229-3026
SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACTThis report is a summary of our first year's work on the proposed research. During this period, our effort was focused on technological development for thermal ablation in mice. Our goal was to establish a small-animal MR-guided HIFU experimental system that enables simultaneous HIFU ablation and MR guidance. This goal was achieved and our experimental results demonstrated the basic function of the experimental system in in-vitro studies. We have laid the groundwork for the feasibility investigation of mouse tumor ablation in the second year. Based on the current progress, we will continue work on our technological improvement of MR-guided HIFU system for in-vivo studies. We believe this system will be ready for animal experiments after several further in-vitro studies in two or three months.
SUBJECT TERMSMR-guided HIFU, renal angiomyolipoma, tumor, ablation, thermal therapy, TSC The proposed project aims to investigate whether MR-guided HIFU offers the ability to ablate renal angiomyolipomas in a mouse tumor model. We expect that the research experience gained from this preclinical study will benefit our future study on non-invasive thermal therapy of renal angiomyolipomas in human with MR-guided HIFU. In the proposed work, we had planned to focus on the development of an MR-guided HIFU experimental system for thermal ablation in mouse kidneys in the first year and perform animal experiments using the technique developed in the second year.The physical mechanisms underlying HIFU is that a HIFU transducer constructed with a concave shape and/or multiple elements has the ability to focus a...