Magneto-mechanical effects of magnetite nanoparticles on Walker-256 carcinosarcoma heterogeneity, redox state and growth modulated by an inhomogeneous stationary magnetic field

Орел, В.Е.; Dasyukevich, O I; Rykhalskyi, O.; Orel, Valerii B.; Burlaka, Anatoliy; Virko, Sergii

doi:10.1016/j.jmmm.2021.168314

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…The form and size of the nanoparticles or associated agglomerates determine potential placement inside the respiratory route, and they have been kept in the airways to a greater extent compared to larger inhalable particulates. In view of creature research, nanoparticles are able to invade the circulation system driving out of the lungs also transfer to different organs, in addition to the CNS [77]. The inward breath danger is impacted through the dustiness of the components, the inclination of particles to become airborne in light of an improvement.…”

Section: Nutritional Valuementioning

confidence: 99%

Nanomaterials: A Potential Hope for Life Sciences from Bench to Bedside

Shinde¹,

Patwekar

et al. 2022

Journal of Nanomaterials

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In this review we hope to explain regarding nanoparticles (NPs), Nanoparticles are very small materials that range from 1 to 100 nm size. And the subclasses of nanoparticles are mentioned. Nanomaterials are formulated by nanoparticles. Research on nanomaterials is used to improve in material technology and synthesis gained the support. Nanomaterials are gradually becoming popularized and starting to arise as commodities. Nanotechnology refers to a set of scientific disciplines and designing where peculiarities that occur at aspects in the nanometre scale are used in the plan, characterization, formulation and use of materials, structures gadgets and system. Here application of nanomaterial and nanotechnology is explained. The use of nanomaterials in the production of biosensors for detection of pathogens, formulation of nanomaterial-based biosensors for detection of antibiotics, Nanomedicines and the application of nanotechnology in food business Etc were discussed. Hazards and risk of nanomaterials are studied under nanotoxicology. Nanotechnology is ab arising science as would be considered normal to have quick areas of strength for improvements. It is anticipated to contribute altogether to financial development and occupation creation in the next few decades.

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Section: Nutritional Valuementioning

confidence: 99%

Nanomaterials: A Potential Hope for Life Sciences from Bench to Bedside

Shinde¹,

Patwekar

et al. 2022

Journal of Nanomaterials

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“…Magnetomechanical and magnetochemical effects modulated tumor heterogeneity and iron‐dependent ROS generation. For this reason, the authors suggested short durations of nonuniform CMF targeting, use of slowly rotating nonuniform CMFs or combination with EMF for tumor growth inhibition (V. E. Orel, Dasyukevich, et al, 2021).…”

Section: Limitations and Challenges For Future Clinical Translationmentioning

confidence: 99%

Nanotherapy based on magneto‐mechanochemical modulation of tumor redox state

Orel

Papazoglou

Tsagkaris³

et al. 2022

WIREs Nanomed Nanobiotechnol

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Magnetic nanoparticles (MNs) are typically used as contrast agents for magnetic resonance imaging or as drug carriers with a remotely controlled delivery to the tumor. However, they can also potentiate the action of anticancer drugs under the influence of applied constant magnetic (CMFs) and electromagnetic fields (EMFs). This review demonstrates the role of magneto‐mechanochemical effects produced by MNs alone and loaded with anticancer agents (MNCs) in response to CMFs and EMFs for modulation of tumor redox state. The combined treatment is suggested to act by two mechanisms: spin‐dependent electron transport propagates free radical chain reactions, while magnetomechanical interactions cause conformational changes in drug molecules loaded onto MNs and generate reactive oxygen species (ROS). By adjusting the parameters of CMFs and EMFs during the magneto‐mechanochemical synthesis and subsequent treatment, it is possible to modulate ROS production and switch redox signaling involved in ERK1/2 and NF‐κB pathways from initiation of tumor growth to inhibition. Observations of tumor volume in different animal models and treatment combinations reported a 6%–70% reduction as compared with conventional drugs. Despite these results, there is a general lack of research in magnetic nanotheranostics that link redox changes across multiple levels of organization in the tumor‐bearing host. Further multidisciplinary studies with more focus on the relationship between the electron transport processes in biomolecules and their effects on the tumor‐host interaction should accelerate the clinical translation of magnetic nanotheranostics. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…43–45 Several studies have already demonstrated that nano- and micrometre-sized particles with different shapes induce the death of cancer cells upon low-frequency alternating or rotating magnetic fields. 46–51 However, the study 52 reports an insignificant effect of the magneto-mechanical effect on cell viability with the application of micrometre particles, while nanoparticles increase the destroyed cell rate to 30% among cells with internalized particles. Thus, to improve the quality of therapy, the drug should have high stability in biological media, low cytotoxicity of the material itself, high energy of particle interaction with an external magnetic field at a small particle size, and selectivity of action.…”

Section: Introductionmentioning

confidence: 96%