Novel candidate theranostic radiopharmaceutical based on strontium hexaferrite nanoparticles conjugated with azacrown ligand

Khabirova, Sofia Yurievna; Aleshin, Gleb Yu.; Anokhin, Evgeny O.; Shchukina, Anna A.; Zubenko, Anastasia D.; Федорова, О. А.; Averin, A. A.; Trusov, Lev A.; Kalmykov, Stepan N.

doi:10.1039/d2dt03548k

Cited by 5 publications

(2 citation statements)

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“…Earlier, we have developed a strategy for the synthesis of the bifunctional derivative of similar pyridine azacrown ether . The ligand has been bound with nanoparticles via the group associated with pyridine, and the final conjugate was successfully labeled. , …”

Section: Discussionmentioning

confidence: 99%

“…55 The ligand has been bound with nanoparticles via the group associated with pyridine, and the final conjugate was successfully labeled. 56,57 Taken together, H 4 BATA is a superior candidate for further conjugation with antibodies and for the application in radioimmunotherapy by a 225 Ac radionuclide. Additionally, H 4 BATA can be used for La 3+ complexation, meaning the possibility of combination of 225 Ac and 132,133,135 La radioisotopes for theranostic application.…”

Section: ■ Conclusionmentioning

confidence: 99%

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Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties

Matazova,

Egorova,

Zubenko

et al. 2023

Inorg. Chem.

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In the current research, we conducted a comparative study of the Ac 3+ complex with H 4 DOTA and H 4 BATA. The stability constants of the [AcBATA] − and [AcDOTA] − complexes were studied directly by extraction methods. We discovered that the thermodynamic properties of the [AcBATA] − complex are superior to those of [AcDOTA] − . Moreover, the fast kinetics of H 4 BATA complexation with Ac 3+ during the radiolabeling experiment was observed already at room temperature. Ac 3+ was placed inside the macrocyclic cavity of the [AcBATA] − complex, preventing the release of the cation. According to DFT studies, two possible conformations were found, where two pendant arms coordinate with the metal cation on one side of the azacrown cavity and two on the other side, or three pendant arms are located on one side and one on the other. Finally, high inertness in vitro and in vivo of [AcBATA] − was discovered, making the H 4 BATA ligand highly preferable for application as a component of actinium-based radiopharmaceuticals.

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Section: Discussionmentioning

confidence: 99%