Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

Abstract

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

Recent progress of magnetic nanoparticles in biomedical applications: A review

“…[ 197 ] To address the challenges associated with initial burst release, Keshavarz et al. [ 200 ] reported a novel method to synthesize the nanocarriers by embedding the magnetic core MSNs shell particles into a polymeric material. Polycarboxybetaine methacrylate (PCBMA) prevents the initial burst release of the drug molecules inside the pores of the MSNs.…”

“…The drug release profile was tested for 125 hours and the drug release profile suggested less than 20% of the loaded drug release in the first 24 hours, indicating reduction of the burst release effect of the nanocarriers. [ 200 ] Moreover, the magnetic nanocomposite can also be used to induce magnetic hyperthermia in the tumors. The specific absorption rate (SAR) value of the OA‐Fe 3 O 4 @mSiO 2 @PCBMA was found to be 34.79 w g −1 .…”

“…The specific absorption rate (SAR) value of the OA‐Fe 3 O 4 @mSiO 2 @PCBMA was found to be 34.79 w g −1 . [ 200 ]…”

A critical review of bioceramics for magnetic hyperthermia

“…However, there are two issues related to these NPs: burst effect and protein corona. 186 In this regard, such NPs are mostly coated with polymeric materials. When a magnetic bioceramic is heated by AMF, and this ceramic is coated with a thermally responsive polymer, the heat generated by HT can trigger drug release, which could substantially increase the efficiency of killing the cancer cell.…”

“…185 In another study, a core-shell structure of mesoporous silica NPs with the core of iron oxide (Fe 3 O 4 ) was coated with poly(carboxybetaine methacrylate) (pCBMA). 186 In order to evaluate the suitability of these NPs for drug delivery, an antibreast cancer drug (Tamoxifen) was loaded to the NPs; results proved that Fe 3 O 4 @mSiO 2 @PCBMA had a stable drug release with less than 20% of the drug released in the first 24 h, demonstrating that the problem of burst effect had A survey of the published literature modeling of CMCs has been studied by a n ers. Processes that have been modeled CVD, 17,18 CVI, [19][20][21][22] and Sol-Gel Infiltrat of alumina matrix in eight-harness satin has been studied numerically in Ref.…”