Magnetism-assisted modification of screen printed electrode with magnetic multi-walled carbon nanotubes for electrochemical determination of dopamine

Abstract

A simple and sensitive dopamine (DA) electrochemical sensor was fabricated based on magnetism-assisted modification of screen printed electrode (SPE) with magnetic multi-walled carbon nanotubes (mMWCNTs). The mMWCNTs modified electrodes (mMWCNTs/SPE) combines the advantages of SPE and the simultaneous contribution of magnetic nanoparticles (MNPs) and MWCNTs, increasing sensitivity and selectivity of DA detection. The linearity was found between 5μM to 180μM, with the limit of detection (LOD) of 0.43μM. In the mean time, this modified electrode exhibited excellent selectivity for DA detection with almost no interference from ascorbic acid (AA), which co-exists with DA in many bio-samples and causes common interference. Finally, this novel electrode has been applied to determine DA concentration in spiked human blood serum and satisfactory recovery was found in the range of 97.43-102.94% with the RSDs of less than 2.27%. This work developed a sensitive and reliable electrochemical analytical method based on mMWCNTs/SPE, which exhibits great potential for diagnosis of the diseases related to DA.

Facile preparation of a cellulose microfibers–exfoliated graphite composite: a robust sensor for determining dopamine in biological samples

“…To explain the advantages and novelty of the sensor, the analytical parameters of the sensor was compared with existing DA sensors and comparative results are shown in Table 1. As can be seen that the fabricated DA sensor exhibited a lower LOD, higher sensitivity, and a wider linear range in the detection of DA than previously reported DA sensors using different composite modified electrodes (Palanisamy et al 2013;Palanisamy et al 2016a;Palanisamy et al 2016b;Shanbhag et al 2017;Xu et al 2017;Caetano et al 2017;Rahman et al 2017;Haldorai et al 2017;Yang et al 2017;Fang et al 2017;Daemia et al 2017;Wang et al 2017;Zhang et al 2017;Vellaichamy et al 2017b). Accordingly, graphite-CMF composite modified SPCE represent an alternative sensitive catalyst for low-level detection of DA.…”

Development of portable electrochemical devices on polymer materials using CO>sub<2>/sub< laser for analytical applications

“…Moreover, the calculated LODs were comparable to the reported in the literature for DP and UA determination using carbon-based electrodes, although most use some modifiers to decrease the LOD 114,[202][203][204][205] . Thus, competitive values of LOD are presented here using the proposed non-modified laser-scribed electrode.…”

Progress in electrochemical detection of neurotransmitters using carbon nanotubes/nanocomposite based materials: A chronological review

“…Using AP for determining various DA concentration at this electrode, LOD of 10 nM was obtained. This LOD is much lower than the value reported by Zhang et al [166] The electrode was further used for the detection of DA in the mouse brain tissue.…”

“…Another means of immobilizing magnetic nanoparticles (MNPs) on MWCNTs was employed by Zhang et al for the modification of SPE. [166] Magnetic MWCNTs (mMWCNT) was fabricated by the combination of carboxylated MWC-NTs and hydrated FeCl 3 . A homogeneous solution of the mMWCNT was magnetically dropped on the surface of SPE to obtain mMWCNT/SPE while m/SPE was obtained by the direct modification of the SPE with MNPs.…”