Magnetically responsive polycaprolactone nanocarriers for application in the biomedical field: magnetic hyperthermia, magnetic resonance imaging, and magnetic drug delivery

Szczęch, Marta; Orsi, Davide; Łopuszyńska, Natalia; Cristofolini, Luigi; Jasiński, K; Węglarz, Władysław P.; Albertini, F.; Kereı̈che, Sami; Szczepanowicz, Krzysztof

doi:10.1039/d0ra07507h

Cited by 18 publications

(6 citation statements)

References 65 publications

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“…Thanks to their magnetic properties, SPIONs can be guided to the diseased area by applying an external magnetic field: this guarantees a higher accumulation within the region of interest, improving efficacy and reducing side effects, and is even more convenient when IONPs are co-delivered with drugs. 127,128 Effective coatings and functionalisation strategies allow cancer cells to be specifically targeted, with a precision at the cellular level. A considerable amount of research is focused on tailoring the surface of SPIONs and of their nanocomposites with biological molecules that can interact with specific receptors on target cells; this strategy can deliver nanocarriers to deep-seated tumours, providing localized hyperthermia, and preventing damage to healthy tissues.…”

Section: Discussionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

et al. 2022

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“…These hydrogel and ceramic scaffolds cannot undergo large magnetically triggered deformations, as they lack the wide elastic range of PCL and other thermoplastics, which can act as a reinforcing platform for stimulation. Although the development of thermoplastic/ION composites for cellular scaffolds has been addressed previously [30,44,[53][54][55] , efforts have focused on magnetic hyperthermia, imaging, and other applications of ION, without proper evaluation of the actuation potential of these composites. In the face of this issue, the results here presented confirm the potential of PCL/rGNP@ MEW scaffolds as tunable platforms for controlled outof-plane actuation and magnetically induced mechanical stimulation.…”

Section: Mechanical Behavior and Magnetic Actuation Of Pcl And Pcl/rg...mentioning

confidence: 99%

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Servin

Dahri

Meneses

et al. 2023

Preprint

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Tunable culture platforms that guide cellular organization and mechanically stimulate skeletal muscle development are still unavailable due to limitations in biocompatibility and actuation triggered without contact. This study reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) of a thermoplastic/graphene/iron oxide composite. In situ deposition of iron oxide nanoparticles on oxidized graphene yielded homogeneously dispersed magnetic particles with sizes above 0.5 micrometer and low aspect ratio, preventing cellular internalization and toxicity. With these fillers, homogeneous magnetic composites with very high magnetic filler content (up to 10 wt.%) were obtained and successfully processed in a solvent-free manner for the first time. MEW of magnetic composites enabled the skeletal muscle-inspired design of hexagonal scaffolds with tunable fiber diameter, reconfigurable modularity, and zonal distribution of magneto-active and nonactive material. Importantly, the hexagonal microstructures displayed elastic deformability under tension, mitigating the mechanical limitations due to high filler content. External magnetic fields below 300 mT were sufficient to trigger out-of-plane reversible deformation leading to effective end-to-end length decrease up to 17%. Moreover, C2C12 myoblast culture on 3D Matrigel/collagen/MEW scaffolds showed that the presence of magnetic particles in the scaffolds did not significantly affect viability after 8 days with respect to scaffolds without magnetic filler. Importantly, in vitro culture demonstrated that myoblasts underwent differentiation at similar rates regardless of the presence of magnetic filler. Overall, these innovative microfiber scaffolds were proven as a magnetically deformable platform suitable for dynamic culture of skeletal muscle with potential for in vitro disease modeling.

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“…This was attributed to the combined effect of the presence of ferromagnetic Fe 2 O 3, embedded in the macromolecular structure, causing perturbation of the local magnetic field as well as the interaction of the water with the macromolecular structure of nanocapsules. The presented LbL method for nanocapsule preparation was further exploited by Szczęch et al [146] for the preparation of multifunctional magnetically responsive polymeric-based nanocarriers optimized for biomedical applications. This hybrid delivery system was composed of drug-loaded polymer PCL nanoparticles coated with a multilayer shell of bio-acceptable components: PGA and SPIONs.…”

Section: Negative Contrastmentioning

confidence: 99%

Contrasting Properties of Polymeric Nanocarriers for MRI-Guided Drug Delivery

Łopuszyńska

Węglarz

2023

Nanomaterials

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Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, leading to its increased half-life. It can also improve the solubility and stability of drugs, advance their distribution and targeting, ensure a sustained release, and reduce drug resistance by delivering multiple therapeutic agents simultaneously. Furthermore, nanotechnology enables the combination of therapeutics with biomedical imaging agents and other treatment modalities to overcome the challenges of disease diagnosis and therapy. Such an approach is referred to as “theranostics” and aims to offer a more patient-specific approach through the observation of the distribution of contrast agents that are linked to therapeutics. The purpose of this paper is to present the recent scientific reports on polymeric nanocarriers for MRI-guided drug delivery. Polymeric nanocarriers are a very broad and versatile group of materials for drug delivery, providing high loading capacities, improved pharmacokinetics, and biocompatibility. The main focus was on the contrasting properties of proposed polymeric nanocarriers, which can be categorized into three main groups: polymeric nanocarriers (1) with relaxation-type contrast agents, (2) with chemical exchange saturation transfer (CEST) properties, and (3) with direct detection contrast agents based on fluorinated compounds. The importance of this aspect tends to be downplayed, despite its being essential for the successful design of applicable theranostic nanocarriers for image-guided drug delivery. If available, cytotoxicity and therapeutic effects were also summarized.

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Magnetically responsive polycaprolactone nanocarriers for application in the biomedical field: magnetic hyperthermia, magnetic resonance imaging, and magnetic drug delivery

Abstract: There are huge demands on multifunctional nanocarriers to be used in nanomedicine.

Cited by 18 publications

References 65 publications

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Contrasting Properties of Polymeric Nanocarriers for MRI-Guided Drug Delivery

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