Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

Read, Jordan E.; Luo, Dong Hua; Chowdhury, Tina T.; Flower, Rod; Poston, Robin N.; Sukhorukov, Gleb B.; Gould, David

doi:10.1039/c9nr10329e

Cited by 18 publications

(12 citation statements)

References 54 publications

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“…The possibility of ROS generation by MNPs, QDs, or carbon nanotubes significantly restricts their biomedical application [ 45 , 46 ]. However, the encapsulation of MNPs and QDs within the polyelectrolyte has been shown to enhance nanoparticle biocompatibility, probably due to the limitation of direct contact of the nanoparticles with live cells due to their entrapment between polymer layers, which mitigates the possible effect of ROS entities on live cells [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle-Doped Hybrid Polyelectrolyte Microcapsules with Controlled Photoluminescence for Potential Bioimaging Applications

et al. 2021

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Fluorescent imaging is widely used in the diagnosis and tracking of the distribution, interaction, and transformation processes at molecular, cellular, and tissue levels. To be detectable, delivery systems should exhibit a strong and bright fluorescence. Quantum dots (QDs) are highly photostable fluorescent semiconductor nanocrystals with wide absorption spectra and narrow, size-tunable emission spectra, which make them suitable fluorescent nanolabels to be embedded into microparticles used as bioimaging and theranostic agents. The layer-by-layer deposition approach allows the entrapping of QDs, resulting in bright fluorescent microcapsules with tunable surface charge, size, rigidity, and functional properties. Here, we report on the engineering and validation of the structural and photoluminescent characteristics of nanoparticle-doped hybrid microcapsules assembled by the deposition of alternating oppositely charged polyelectrolytes, water-soluble PEGylated core/shell QDs with a cadmium selenide core and a zinc sulfide shell (CdSe/ZnS), and carboxylated magnetic nanoparticles (MNPs) onto calcium carbonate microtemplates. The results demonstrate the efficiency of the layer-by-layer approach to designing QD-, MNP-doped microcapsules with controlled photoluminescence properties, and pave the way for the further development of next-generation bioimaging agents based on hybrid materials for continuous fluorescence imaging.

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Section: Resultsmentioning

confidence: 99%

Nanoparticle-Doped Hybrid Polyelectrolyte Microcapsules with Controlled Photoluminescence for Potential Bioimaging Applications

et al. 2021

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“…Moreover, magnetic LbL-assembled capsules present a strong magnetic response that derives from the coherent effect of thousands of MNPs tied in one entity [29,104]. In such a manner, they represent a unique delivery system allowing for remote navigation or holding with an external magnet not only in vitro [105], but in complex dynamics of in vivo as well. For instance, Voronin et al prepared magnetic multilayered microcapsules via LbL deposition of poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate), and then demonstrated that these systems could be effectively controlled in a blood flow [104].…”

Section: Magnetic Microcapsulesmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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“…It was demonstrated the viability of HeLa and 293T cells was not altered after 24 h of exposure to the PEMCs. Following the application of a magnetic field, the phagocytosed capsules can be retained at the target site under physiologically relevant shear stress conditions, following HeLa-EGFP engulfment [242]. Nanoparticle functionalised PEMCs may also be used in photothermal therapy.…”

Section: Functionalisation With Nanoparticlesmentioning

confidence: 99%

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

Abstract: Magnetically responsive LbL microcapsules are biologically inert, magnetically retained in flow and cell migration assays so are retainable drug delivery vehicles.

Cited by 18 publications

References 54 publications

Nanoparticle-Doped Hybrid Polyelectrolyte Microcapsules with Controlled Photoluminescence for Potential Bioimaging Applications

Nanoparticle-Doped Hybrid Polyelectrolyte Microcapsules with Controlled Photoluminescence for Potential Bioimaging Applications

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

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