Magnetically optimized SERS assay for rapid detection of trace drug-related biomarkers in saliva and fingerprints

Yang, Tianxi; Guo, Xiaoyu; Wang, Hui; Fu, Shuyue; Wen, Ying; Yang, Haifeng

doi:10.1016/j.bios.2015.01.021

Cited by 76 publications

(43 citation statements)

References 47 publications

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“…The latest study published aimed to the detection of drugs in oral fluid by SERS was performed employing Au NPs dotted Magnetic Nanocomposites (AMN) modified with inositol hexakisphosphate (IP 6 ) as SERS substrate [28]. Actually, in this case, the goal was to detect drug-related biomarkers in oral fluid and fingerprints to be able to indicate the amount of the 19 achieved was lower than the one previously reported.…”

Section: Raman Spectroscopymentioning

confidence: 96%

“…Nevertheless, until now, only few published studies deal specifically on the detection of drugs in oral fluids by Raman spectroscopy (see table 1) and all have been performed with the SERS mode [23][24][25][26][27][28].…”

Section: Raman Spectroscopymentioning

confidence: 99%

“…Actually, in this case, the goal was to detect drug-related biomarkers in oral fluid and fingerprints to be able to indicate the amount of the 19 achieved was lower than the one previously reported. Then, it could be concluded that a portable Raman-analyser-AMN-based and a magnetically optimized technique could be employed as onsite protocol to screen trace drugs of abuse in biological fluids and to differentiate the drug addicts from the smokers [28].…”

Section: Raman Spectroscopymentioning

confidence: 99%

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Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid

D’Elia

Montalvo

García-Ruiz

2015

Applied Spectroscopy Reviews

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The present work aims to review all the papers published so far, focused on the determination of drugs of abuse in oral fluid. This fluid provides a simpler, faster and more controllable sampling in comparison with the other biological fluids such as blood or urine. Actually, the main goal of the researchers is to lower the limit of detection (LOD) to detect quantities of drugs smaller than the cut-off limits established by law for drug controls. Advances in Raman, Infrared (IR) andNuclear Magnetic Resonance (NMR) spectroscopy applications are here discussed. Surface Enhanced Raman Spectroscopy (SERS) has been shown as the most sensitive technique for the detection of illicit drugs in oral fluid. The use of IR spectroscopy for determining drugs of abuse in oral fluid is growing although the LODs obtained until now do not yet satisfy the necessities in the forensic field. Finally, NMR spectroscopy has been seldom used to determine drugs in oral fluid. Another future trend seems to be related with the use of portable instrumentation, which would permit to perform in-situ analysis. This last application seems to be particularly promising to perform roadside drug tests and to identify overdose drugs in patients in emergency conditions.

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Section: Raman Spectroscopymentioning

confidence: 96%

Section: Raman Spectroscopymentioning

confidence: 99%

Section: Raman Spectroscopymentioning

confidence: 99%

See 1 more Smart Citation

Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid

D’Elia

Montalvo

García-Ruiz

2015

Applied Spectroscopy Reviews

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“…SERS, with its potential for extremely high enhancement levels, transforms Raman spectroscopy from a structural analytical tool to a structurally sensitive single-molecule probe [6]. The SERS signal decays exponentially with distance from the metal surface, and the surface plasmon resonance prompts strong Raman scattering of a target species within an optimum spatial zone of 0e4 nm, where the electromagnetic fields are localized [7]. For molecules possessing high hydrophobicity such as PAHs, great efforts must be made to facilitate their affinity towards SERS substrates.…”

Section: Introductionmentioning

confidence: 99%

Au nanoparticles grafted on Fe3O4 as effective SERS substrates for label-free detection of the 16 EPA priority polycyclic aromatic hydrocarbons

Sun

et al. 2016

Analytica Chimica Acta

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“…Yang and co-workers used Au NPs dotted magnetic nanocomposites (AMN) modified with inositol hexakisphosphate (IP6) as SERS substrate to quickly monitor drug-related biomarkers in saliva and to trace on-site screen drug biomarker in fingerprints [119]. The substrate presented a huge SERS activity by inducing with an external magnet.…”

Section: Drug Metabolitesmentioning

confidence: 99%

SERS Nanotags and Their Applications in Biosensing and Bioimaging

et al. 2018

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Owing to the unique advantages of surface enhanced Raman scattering (SERS) in high sensitivity, specificity, multiplexing capability and photostability, it has been widely used in many applications, among which SERS biosensing and bioimaging are the focus in recent years. The successful applications of SERS for non-invasive biomarker detection and bioimaging under in vitro, in vivo and ex vivo conditions, offer significant clinical information to improve diagnostic and prognostic outcomes. This review provides recent developments and applications of SERS, in particular SERS nanotags in biosensing and bioimaging, describing case studies in which different types of biomarkers have been investigated, as well as outlining future challenges that need to be addressed before SERS sees both pathological and clinical use.

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Magnetically optimized SERS assay for rapid detection of trace drug-related biomarkers in saliva and fingerprints

Cited by 76 publications

References 47 publications

Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid

Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid

Au nanoparticles grafted on Fe3O4 as effective SERS substrates for label-free detection of the 16 EPA priority polycyclic aromatic hydrocarbons

SERS Nanotags and Their Applications in Biosensing and Bioimaging

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