Magnetically-guided hydrogel capsule motors produced via ultrasound assisted hydrodynamic electrospray ionization jetting

Rutkowski, Sven; Si, Tieyan; Gai, Meiyu; Sun, Mengmeng; Frueh, Johannes; He, Qiang

doi:10.1016/j.jcis.2019.01.103

Cited by 38 publications

(31 citation statements)

References 63 publications

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“…Upon the combination of electrospinning and electrospray methods, since the solvent of nanofibers is not still vaporized completely, they would seem soft, causing the colloidal molecules to stick to the polymer (Figure 7). 124,125 The nanofibers created as a result of not being fully vaporized bind better to the fibers when they collide with the drug molecules 126 . In the combination of electrospray and electrospinning procedures, the drug release is affected by many factors.…”

Section: Combination Of Electrospinning and Electrospraymentioning

confidence: 99%

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Ghaderpour

Hoseinkhani

Yarani

et al. 2021

Polymers for Advanced Techs

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Nowadays, nanofibers have various applications in the field of medical biology including drug delivery systems (DDSs) and tissue engineering. Many methods have been developed to produce drug release polymers; the most important and applicable of which is known as electrospinning. In this method, the nanoscale and microscale fibers are used as the functional polymers in the DDSs. A variety of electrospinning methods can be used for delivery systems and tissue engineering. The nanofibers loaded with anticancer drugs have attracted a lot of attention in the last decade. Electrospun parameters include voltage, feed rate, rotary collector, pipette or needle hole diameter, the distance between nozzle tip to collector plate, viscosity and molecular weight of the polymer, surface tension, solubility of polymer, soluble electrical conductivity, dielectric constant, and evaporability of the solution; all could be manipulated to regulate the drug release rate in order via changing the diameter of the nanofibers. In addition to directly loading the drug on nanofibers, the nanoparticles are also used to improve the drug efficacy and reduce the required dose, especially in the case of harmful drugs. Depending on the need, various nanoparticles and nanocarriers are being applied along with the drug. Nanocarriers such as viruses, micelles, and liposomes function highly specific since they carry specific ligands on their surface. Magnetic nanoparticles also have a great therapeutic effect on cancer cells when exposed to heat and magnetic fields. Carbon nanoparticles, such as graphene and graphene oxide, due to their layering, can pass through the cell membrane and deliver the drug to the intracellular space.

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Section: Combination Of Electrospinning and Electrospraymentioning

confidence: 99%

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Ghaderpour

Hoseinkhani

Yarani

et al. 2021

Polymers for Advanced Techs

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“…Reproduced with permission. [40] Copyright 2019, Elsevier Inc. www.advmattechnol.de field in a salt solution. [42] Its excellent properties are embodied in the high compressive strength of 59 MPa, 98% fracture strain, and greater than 2000% tensile fracture strain.…”

Section: Electrically Triggered Hydrogel-based Motorsmentioning

confidence: 99%

“…Calcium alginate capsules can also be prepared by the same method, as shown in Figure 6Ca. [ 40 ] The ultrasound power and frequency determine the homogeneity of the gel capsules. The presence of ultrasound causes surface undulations, which not only prevents the formation of a hydrogel layer at the air–water interface, but also induces the surface layer buckling aiding spontaneous capsule closure driven by the differences in surface tension.…”

Section: External‐stimuli‐triggered Hydrogel‐based Motorsmentioning

confidence: 99%

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Hydrogel‐Based Motors

Wang

Ren

Yang

et al. 2021

Adv Materials Technologies

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Inspirations from the movements of organisms in nature have motivated a myriad of researchers to develop innovative intelligent soft matter mimicking the body deformation principles of natural systems. Similar to the sensory and control systems of biological organisms, the environment responsiveness and configurable structure of hydrogel make it an ideal candidate to construct biomimetic soft matters. This review highlights the progresses made toward developing hydrogel‐based motors from two aspects: chemically induced autonomous propulsion and external‐stimuli‐induced propulsion. According to the classification based on propulsion mechanisms, the design principles, fabrication methods, and motion characterization are discussed. By reviewing the efforts in the rapidly increasing multidisciplinary field, the framework of designing hydrogel‐based smart soft devices able to operate autonomously is outlined and ongoing research targets to meet the intended purpose are proposed.

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“…Recent demonstrations show fuel-free micromotors powered by external fields. For instance, applications of magnetic field [55,56], light source [57][58][59][60][61][62], ultrasound [63,64], temperature [65], and electric field [66] are used to generate the motive force of externally powered/controlled micromotors. For example, a light-powered Au-WO 3 @C motor, shown in Figure 2(b), consists of a colloidal carbon WO 3 nanoparticle composite.…”

Section: Suitable Propulsion Modes Motion Control and Missionmentioning

confidence: 99%

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

Lin

Zhu

et al. 2020

Research

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With controllable size, biocompatibility, porosity, injectability, responsivity, diffusion time, reaction, separation, permeation, and release of molecular species, hydrogel microparticles achieve multiple advantages over bulk hydrogels for specific biomedical procedures. Moreover, so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli, which significantly limit the scope of their applications. Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion. If hydrogels can be integrated with micromotors, their applicability can be significantly extended and can lead to fully controllable responsive chemomechanical biomicromachines. However, to achieve these challenging goals, biocompatibility, biodegradability, and motive mechanisms of hydrogel micromotors need to be simultaneously integrated. This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors, which become increasingly important for in vivo and in vitro bioapplications.

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Magnetically-guided hydrogel capsule motors produced via ultrasound assisted hydrodynamic electrospray ionization jetting

Cited by 38 publications

References 63 publications

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Hydrogel‐Based Motors

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

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