Magnetically-controllable zigzag structures as cell microgripper

Ger, Tzong-Rong; Huang, Hao-Ting; Chen, We-Yun; Lai, Mei-Feng

doi:10.1039/c3lc50287b

Cited by 43 publications

(27 citation statements)

References 21 publications

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“…Due to the larger surface area of NPs which increase the interactions between NPs and cell membrane, the internalization of NPs by cells is effective and which is attractive for delivering drugs, probes or proteins [5], [6], [7]. Among the NPs, magnetic iron oxide NPs are considered highly biocompatible and commonly used for biomedical applications as magnetic resonance imaging (MRI) contrast agents [8], [9], to magnetically label the cells for cell separation [10] and cell sorting [11] or as heat generators for magnetic hyperthermia (MH) [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level

et al. 2014

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Developing methods that evaluate the cellular uptake of magnetic nanoparticles (MNPs) and nanotoxicity effects at single-cellular level are needed. In this study, magnetophoresis combining fluorescence based cytotoxicity assay was proposed to assess the viability and the single-cellular MNPs uptake simultaneously. Malignant cells (SKHep-1, HepG2, HeLa) were incubated with 10 nm anionic iron oxide nanoparticles. Prussian blue stain was performed to visualize the distribution of magnetic nanoparticles. MTT and fluorescence based assay analyzed the cytotoxicity effects of the bulk cell population and single cell, respectively. DAPI/PI stained was applied to evaluate death mechanism. The number of intracellular MNPs was found to be strongly correlated with the cell death. Significant differences between cellular MNP uptake in living and dead cells were observed. The method could be useful for future study of the nanotoxicity induced by MNPs.

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Section: Introductionmentioning

confidence: 99%

Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level

et al. 2014

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“…Numerous microgrippers with different actuating mechanisms, such as electrostatic [1], thermal [2], piezoelectric [3], magnetic [4], pneumatic [5], and direct mechanical contact approaches [6], have been reported in recent decades. However, the existing microgrippers may encounter problems in manipulating micro-devices and biological tissue in the experiments that last for hours or longer.…”

Section: Introductionmentioning

confidence: 99%

A microgripper with a ratchet self-locking mechanism

Hao

Yuan

Zhang

et al. 2015

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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This paper reports a new design for an electrostatic actuated microgripper with a ratchet self-locking mechanism.The self-locking mechanism enables long-time gripping without continuously applying the external driving signal, such as an electrical, thermal or magnetic field, which significantly reduces the effect and damage on the gripped micro-scale objects that are induced by the external driving signals. The microgripper is fabricated using a silicon-on-insulator (SOI) wafer with a 30μm device layer. The jaw gap is 100 μm, and the ratchet locking interval is 10 μm. A metal wire is successfully gripped to demonstrate the feasibility of the ratchet self-locking mechanism.

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“…Other approaches for the separation of objects and manipulators are proposed by using an external electric field, magnetic field force [18] or liquid frozen method [19], which called active release without contacting with the substrate. Those kinds of releasing ways do not depend on the surface properties of the substrate, but have difficulty in the miniaturization of grippers and require complex peripherals.…”

Section: Introductionmentioning

confidence: 99%

A PZT Actuated Triple-Finger Gripper for Multi-Target Micromanipulation

et al. 2017

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This paper presents a triple-finger gripper driven by a piezoceramic (PZT) transducer for multi-target micromanipulation. The gripper consists of three fingers assembled on adjustable pedestals with flexible hinges for a large adjustable range. Each finger has a PZT actuator, an amplifying structure, and a changeable end effector. The moving trajectories of single and double fingers were calculated and finite element analyses were performed to verify the reliability of the structures. In the gripping experiment, various end effectors of the fingers such as tungsten probes and fibers were tested, and different micro-objects such as glass hollow spheres and iron spheres with diameters ranging from 10 to 800 μm were picked and released. The output resolution is 145 nm/V, and the driven displacement range of the gripper is 43.4 μm. The PZT actuated triple-finger gripper has superior adaptability, high efficiency, and a low cost.

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Magnetically-controllable zigzag structures as cell microgripper

Cited by 43 publications

References 21 publications

Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level

Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level

A microgripper with a ratchet self-locking mechanism

A PZT Actuated Triple-Finger Gripper for Multi-Target Micromanipulation

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