Magnetic Trapping of Bacteria at Low Magnetic Fields

Wang, Zhao Meng; Wu, Rui Ge; Wang, Zhi Ping; Ramanujan, R.V.

doi:10.1038/srep26945

Cited by 36 publications

(27 citation statements)

References 35 publications

(47 reference statements)

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“…The team extended their work to separate and concentrate bacteria and magnetic nanoparticles on different parts of the island. 95 The magnetic particles were concentrated at the tip of the island. The bacteria were accumulated at the center of the island.…”

Section: Magnetophoresis For Trappingmentioning

confidence: 99%

Recent advances and current challenges in magnetophoresis based micro magnetofluidics

2018

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The combination of magnetism and microscale fluid flow has opened up a new era for handling and manipulation of samples in microfluidics. In particular, magnetophoresis, the migration of particles in a magnetic field, is extremely attractive for microfluidic handling due to its contactless nature, independence of ionic concentration, and lack of induced heating. The present paper focuses on recent advances and current challenges of magnetophoresis and highlights the key parameters affecting the manipulation of particles by magnetophoresis. The magnetic field is discussed according to their relative motion to the sample as stationary and dynamic fields. The migration of particles is categorized as positive and negative magnetophoresis. The applications of magnetophoresis are discussed according to the basic manipulation tasks such as mixing, separation, and trapping of particles or cells. Finally, the paper highlights the limitations of current approaches and provides the future perspective for this research area.

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Section: Magnetophoresis For Trappingmentioning

confidence: 99%

Recent advances and current challenges in magnetophoresis based micro magnetofluidics

2018

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“…The sample is introduced to multiple levels of magnetic sorter according to the adjustment of external permanent magnet distance to flowing magnetic-labeled cells, resulting in separation of the cells according to their epithelial cell adhesion molecule (EpCAM) levels into low, moderate, and high expression. Bacteria manipulation using MAG has been achieved by Wang et al [32], who demonstrate the trapping of Bacillus megaterium, which are nonmagnetic bioparticles in a ferrofluid suspension while experiencing uniform external magnetic field. The sample continuously flows in a microfluidic channel with nonmagnetic island located in the middle of the channel.…”

Section: Magnetophoretic Manipulation Of Bioparticlesmentioning

confidence: 99%

Biological Particle Control and Separation using Active Forces in Microfluidic Environments

Ali¹,

Kayani²,

Majlis³

2018

Microfluidics and Nanofluidics

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Exploration of active manipulation of bioparticles has been impacted by the development of micro-/nanofluidic technologies, enabling evident observation of particle responses by means of applied tunable external force field, namely, dielectrophoresis (DEP), magnetophoresis (MAG), acoustophoresis (ACT), thermophoresis (THM), and optical tweezing or trapping (OPT). In this chapter, each mechanism is presented in brief yet concise, for broad range of readers, as strong foundation for amateur as well as brainstorming source for experts. The discussion covers the fundamental mechanism that underlying the phenomenon, presenting the theoretical and schematic description; how the response being tuned; and utmost practical, the understanding by specific implementation into bioparticles manipulation engaging from micron-sized material down to molecular level particles.

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“…There has been significant interest in developing techniques for sorting and organizing single particles and cells in microfluidic chips based on various methods, such as sedimentation into micro-wells, 6-8 encapsulation into droplets, 9-10 capture by hydrodynamic traps, 11-13 as well as active sorting based on electric fields, 14-17 optical tweezers, 18-19 acoustic pressure, 20-21 and magnetic traps. 22-24 Though these technologies have significant promise, 25-27 many challenges must be surmounted to precisely organize the large number of single cells needed to analyze rare cellular events, which can be present at frequencies of 0.1% or less.…”

Section: Introductionmentioning

confidence: 99%

Magnetophoretic transistors in a tri-axial magnetic field

et al. 2016

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The ability to direct and sort individual biological and non-biological particles into spatially addressable locations is fundamentally important to the emerging field of single cell biology. Towards this goal, we demonstrate a new class of magnetophoretic transistors, which can switch single magnetically labeled cells and magnetic beads between different paths in a microfluidic chamber. Compared with prior work on magnetophoretic transistors driven by a two-dimensional in-plane rotating field, the addition of a vertical magnetic field bias provides significant advantages in preventing the formation of particle clumps and in better replicating the operating principles of circuits in general. However, the three-dimensional driving field requires a complete redesign of the magnetic track geometry and switching electrodes. We have solved this problem by developing several types of transistor geometries which can switch particles between two different tracks by either presenting a local energy barrier or by repelling magnetic objects away from a given track, hereby denoted as “barrier” and “repulsion” transistors, respectively. For both types of transistors, we observe complete switching of magnetic objects with currents of ~40 mA, which is consistent over a range of particle sizes (8-15 μm). The switching efficiency was also tested at various magnetic field strengths (50-90 Oe) and driving frequencies (0.1-0.6 Hz); however, we again found that the device performance only weakly depended on these parameters. These findings support the use of these novel transistor geometries to form circuit architectures in which cells can be placed in defined locations and retrieved on demand.

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Magnetic Trapping of Bacteria at Low Magnetic Fields

Cited by 36 publications

References 35 publications

Recent advances and current challenges in magnetophoresis based micro magnetofluidics

Recent advances and current challenges in magnetophoresis based micro magnetofluidics

Biological Particle Control and Separation using Active Forces in Microfluidic Environments

Magnetophoretic transistors in a tri-axial magnetic field

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