Magnetic targeted nanoparticles based on β-cyclodextrin and chitosan for hydrophobic drug delivery and a study of their mechanism

Chen, Pengfei; Song, Hang; Yao, Shun; Xian-yu, TU; Su, Miao; Zhou, Lu

doi:10.1039/c7ra02398g

Cited by 38 publications

(24 citation statements)

References 48 publications

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“…For hydrophobic drugs, the amplification of electrostatic interaction and inclusion complexation introduced by the chitosan layer and the βCyD layer can control the initial burst release followed by sustained release. [125] Supramolecular paramagnetic nanoparticles prepared from adamantane (Ad MNPs). The nanoparticles prepared by molecular association between Ad and CyD motifs for DOX delivery with provided magnetic field stimulus achieve the controlled drug delivery at tumor site.…”

Section: Tumor Targeted Drug Delivery and Imagingmentioning

confidence: 99%

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

351

220

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This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host-guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of functional molecular machines such as polyrotaxane, polypseudorotaxane, and polycatenanes and grafting of cyclodextrin with different linear, branched chain polymers. The different stimuli-based supramolecular assemblies involving cyclodextrin as a key mediator with linked triggering responses on payload release is highlighted. In addition, the applications of cyclodextrin in diagnostic imaging and medical devices is briefly demonstrated. Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio-imaging. The toxicological profile of cyclodextrin is well established and safe for human consumption in food and medicine.

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Section: Tumor Targeted Drug Delivery and Imagingmentioning

confidence: 99%

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

351

220

View full text Add to dashboard Cite

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“…164 Further chemical modifications of CDs and formulation studies are needed to exploit their applications in site specific controlled delivery of drugs through NPs which can be seen from the typical examples indicated in Table 5. [165][166][167][168][169][170][171][172][173] The CD allows NPs to be tuned for tailor-made needs of drug delivery and theranostics through the chemical modifications demonstrating the scope for the researchers from the chemical, biomedical and pharmaceutical field to focus on the utilization of CD in nanoparticulate drug delivery. Along with the issues discussed under this review it attracts our attention to the recent reports indicating the intervention of CD derivatives in the treatment of various diseases.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

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Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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“…As a result, several studies have been directed towards constructing nanoparticles with different structures based on CS and CD to form new drug carriers. Zhou et al., reported Magnetic targeted nanoparticles double coated with β‐CD and CS using a layer‐by‐layer model. They investigated the potential of these nanoparticles for hydrophobic drug delivery using ibuprofen as a model drug.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Polysaccharide Based Nanoparticles

Khan

Abtew

Modani

et al. 2018

Israel Journal of Chemistry

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Nanoparticles made of biodegradable polymers have outstanding merits as a drug delivery system. Polysaccharide-based nanoparticles have been well explored because of their safety, stability, biocompatibility, biodegradability and hydrophilicity. The present review emphasizes the efforts articulated to improve polysaccharide-based nano-particles as drug delivery tool for effective therapy and sitespecific targeting of mainly anticancer agents. This review updates reports of recent research on polysaccharides-based systems particularly chitosan, alginate, cyclodextrins, hyaluronic acid, pullulan, dextran and their combinations with potential applications.

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Magnetic targeted nanoparticles based on β-cyclodextrin and chitosan for hydrophobic drug delivery and a study of their mechanism

Abstract: Magnetic nanoparticles double coated with β-cyclodextrin and chitosan were prepared for hydrophobic drug delivery, and its related mechanism was discussed.

Cited by 38 publications

References 48 publications

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Polysaccharide Based Nanoparticles

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