Magnetic Susceptibility, Anisotropy and Order Parameter of N-(p–n-butoxybenzylidene) p – n-ethylaniline

Rao, K.R.S. Sambasiva; Rao, J. V.; Choudary, L. V.; Venkatacharyulu, P.

doi:10.1524/zpch.1985.146.1.035

Cited by 15 publications

(10 citation statements)

References 12 publications

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“…(b) We have recently observed that the UV-induced chromosome decondensation in mitotic HeLa cells is associated with inactivation of mitotic factors and the induction of IMF (3). (c) In cell fusion experiments, Rao and Johnson (32) and Rao et al (33) observed that the entry of G2 cells into mitosis is delayed after fusion with G, or S phase cells until G, or S phase nuclei in the heterophasic binucleate cells have completed DNA synthesis and subsequently both nuclei have entered mitosis synchronously . They speculated that the G, and S phase components were causing decondensation of chromatin in G2 nuclei, thus blocking them from entering mitosis.…”

Section: Discussionmentioning

confidence: 99%

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Evidence for the presence of inhibitors of mitotic factors during G1 period in mammalian cells.

Adlakha¹,

Sahasrabuddhe²,

Wright³

et al. 1983

The Journal of Cell Biology

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Our earlier studies indicated that the mitotic factors, which induce germinal vesicle breakdown and chromosome condensation when injected into fully grown Xenopus oocytes, are preferentially associated with metaphase chromosomes and that they bind to chromatin as soon as they are synthesized during the G2 phase . In this study, we attempted to determine the fate of these factors as the cell completes mitosis and enters G, . Extracts from HeLa cells at different points during G,, S, and G2 periods were mixed with mitotic extracts in various proportions, incubated, and then injected into Xenopus oocytes to determine their maturationpromoting activity. The maturation-promoting activity of the mitotic extracts was neutralized by extracts of G, cells during all stages of G, but not by those of late S and G 2 phase cells . Extracts of quiescent (Go) human diploid fibroblasts exhibited very little inhibitory activity . However, UV irradiation of G o cells, which is known to cause decondensation of chromatin, significantly enhanced the inhibitory activity of extracts of these cells. These factors are termed inhibitors of mitotic factors (IMF) . They seem to be activated, rather than newly synthesized, as the cell enters telophase when chromosomes begin to decondense. The IMF are nondialyzable, nonhistone proteins with a molecular weight of >12,000 . Since mitotic factors are known to induce chromosome condensation, it is possible that IMF, which are antagonistic to mitotic factors, may serve the reverse function of the mitotic factors, i.e ., regulation of chromosome decondensation .Chromatin undergoes profound structural alterations during the cell cycle . During mitosis, it is supercoiled and condensed to form the mitotic chromosomes. Chromosome condensation is a critical event in the cell cycle that is necessary for the equal distribution of genetic material between the daughter cells. The phenomenon of premature chromosome condensation described by Johnson and Rao (13) has been very useful in visualizing the state of chromatin condensation during interphase. Using this technique, Rao and Hanks (30) and Hanks and Rao (9) have shown that the process of chromosome decondensation, initiated during the telophase of mitosis, continues throughout the G, period until the chromatin reaches its ultimate state ofdecondensation by the end of G,, when DNA synthesis is initiated .As for the factors involved in chromosome condensation, studies from this and other laboratories have demonstrated that when extracts from mitotic HeLa cells (39,40) or mitotic Chinese hamster ovary cells (19) are injected into Xenopus THE JOURNAL OF CELL BIOLOGY -VOLUME 97 DECEMBER 1983 1707-1713 C The Rockefeller University Press -0021-9525/83/12/1707/07 $1 .00 laevis oocytes, they exhibit maturation-promoting activity (MPA)' as evidenced by germinal vesicle breakdown (GVBD) and condensation of chromosomes. These studies also revealed that the mitotic factors are nonhistone proteins and accumulate slowly in the beginning of G2, increase rapid...

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Section: Discussionmentioning

confidence: 99%

“…The results ofthis study indicate the existence ofcertain factors (proteins) during the G, period of mammalian cells that specifically inactivate the mitotic factors as indicated by the loss of their MPA when injected into oocytes . An abstract of this study has appeared elsewhere (27).…”

mentioning

confidence: 99%

Evidence for the presence of inhibitors of mitotic factors during G1 period in mammalian cells.

Adlakha¹,

Sahasrabuddhe²,

Wright³

et al. 1983

The Journal of Cell Biology

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show abstract

“…In the isotropic liquid phase and in the solid phase the molecules are randomly oriented and 2, is measured. Further details were discussed in our earlier paper (Rao, Rao, Choudary and Venkatacharyulu, 1985). The susceptibility anisotropy, Axg (Ax/p, where p is the density) can be very accurately calculated by mass susceptibility measurements on a single crystal for which one needs single crystal X-ray and magnetic data.…”

Section: 5-cmentioning

confidence: 99%

“…Hence we have adopted the following two methods to calculate Axa for EBBA (Rao, Rao, Choudary and Venkatacharyulu, 1985).…”

Section: 5-cmentioning

confidence: 99%

Magnetic susceptibility investigations on EBBA

1987

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“…Heterogeneous photocatalysis provides the means not only for utilizing solar energy but also for new synthetic routes , and pathways of degradation of industrial wastes . Particulate semiconductors suspended in solution or metal-doped semiconductors 2 such as TiO 2 , CdS, ZnO, Fe 2 O 3 , WO 3 , Pt/TiO 2 , Ag/TiO 2 , colloidal TiO 2 , etc., have attracted the attention of many chemists as several reactions which are inaccessible by other means may be accomplished through heterogeneous photocatalysis.…”

Section: Introductionmentioning

confidence: 99%

Photocatalyzed Oxidation of Triphenyl Derivatives of P, As, Sb & Bi and Reduction of Their Oxides

Somasundaram

Srinivasan

1996

J. Org. Chem.

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Magnetic Susceptibility, Anisotropy and Order Parameter of N-(p–n-butoxybenzylidene) p – n-ethylaniline

Cited by 15 publications

References 12 publications

Evidence for the presence of inhibitors of mitotic factors during G1 period in mammalian cells.

Evidence for the presence of inhibitors of mitotic factors during G1 period in mammalian cells.

Magnetic susceptibility investigations on EBBA

Photocatalyzed Oxidation of Triphenyl Derivatives of P, As, Sb & Bi and Reduction of Their Oxides

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