Magnetic Study of the Novel Polynuclear Compound [Cu(II)(6-Mercaptopurinolate2−)]n

Acevedo‐Chávez, Rodolfo; Costas, Marı́a Eugenia; Escudero, R.

doi:10.1006/jssc.1997.7411

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…The peak observed in Figure 2D for pure 6-mercaptopurine at around 1,275 cm −1 can be assigned to the C=S group and the absence of this absorption peak at 1,275 cm −1 in the FCMP compound confirms formation of the 6-mercaptopurine complex via the sulfur atom (Figure 2E). 16 As could be observed, chitosan and 6-mercaptopurine were successfully coated to the iron oxide nanoparticles.…”

Section: Resultsmentioning

confidence: 83%

“…Figure 2B shows the characteristic bands of pure chitosan at around 3,425 cm −1 (O–H stretching and N-H stretching vibrations), 1,658 cm −1 (amide), and 1,064 cm −1 (C–O–C stretching vibration). The absence of a band at 1,155 cm −1 (ν C = S /ring vibration) in Figure 2E suggests participation of an exocyclic (S) atom in metallic bonding of the heterocyclic ligand in the Fe (II) coordination compound 16. The peak at 3,095 cm −1 belongs to the ν C−H aromatic (Figure 2E).…”

Section: Resultsmentioning

confidence: 96%

“…Purine derivatives, such as 6-mercaptoguanine and 6-mercaptopurine, are the focus of intense interest because of their antitumor properties, particularly against leukemia,13–15 and their potent acid-base properties, which offer a variety of metallic bonding sites 15,16. Metal complexes of these bases appear to have more anticancer activity than the free ligands 2,17…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Dorniani¹,

Hussein²,

Kura³

et al. 2013

DDDT

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BackgroundIron oxide nanoparticles are of considerable interest because of their use in magnetic recording tape, ferrofluid, magnetic resonance imaging, drug delivery, and treatment of cancer. The specific morphology of nanoparticles confers an ability to load, carry, and release different types of drugs.Methods and resultsWe synthesized superparamagnetic nanoparticles containing pure iron oxide with a cubic inverse spinal structure. Fourier transform infrared spectra confirmed that these Fe3O4 nanoparticles could be successfully coated with active drug, and thermogravimetric and differential thermogravimetric analyses showed that the thermal stability of iron oxide nanoparticles coated with chitosan and 6-mercaptopurine (FCMP) was markedly enhanced. The synthesized Fe3O4 nanoparticles and the FCMP nanocomposite were generally spherical, with an average diameter of 9 nm and 19 nm, respectively. The release of 6-mercaptopurine from the FCMP nanocomposite was found to be sustained and governed by pseudo-second order kinetics. In order to improve drug loading and release behavior, we prepared a novel nanocomposite (FCMP-D), ie, Fe3O4 nanoparticles containing the same amounts of chitosan and 6-mercaptopurine but using a different solvent for the drug. The results for FCMP-D did not demonstrate “burst release” and the maximum percentage release of 6-mercaptopurine from the FCMP-D nanocomposite reached about 97.7% and 55.4% within approximately 2,500 and 6,300 minutes when exposed to pH 4.8 and pH 7.4 solutions, respectively. By MTT assay, the FCMP nanocomposite was shown not to be toxic to a normal mouse fibroblast cell line.ConclusionIron oxide coated with chitosan containing 6-mercaptopurine prepared using a coprecipitation method has the potential to be used as a controlled-release formulation. These nanoparticles may serve as an alternative drug delivery system for the treatment of cancer, with the added advantage of sparing healthy surrounding cells and tissue.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Dorniani¹,

Hussein²,

Kura³

et al. 2013

DDDT

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“…In addition, the absence of the characteristic absorption band at 1275 cm −1 (C=S group) in the FPEGMP-2 nanocomposite, compared to pure 6-mercaptopurine, confirmed the formation of the 6-mercaptopurine complex by the sulfur atom (Figure 2(D)) [39]. An absorption band at 428 cm −1 in the FPEGMP-2 nanocomposite proved the presence of magnetite nanoparticles after coating procedure.…”

Section: Resultsmentioning

confidence: 89%

“…The absence of a band at 1156 cm −1 which belongs to the ( ν C=S /ring vibration) confirms the participation of an exocyclic (S) atom in metallic bonding of the heterocyclic ligand in the Fe(II) coordination compound ( Figure 2(D) ) [ 39 ]. In addition, the absence of the characteristic absorption band at 1275 cm −1 (C=S group) in the FPEGMP-2 nanocomposite, compared to pure 6-mercaptopurine, confirmed the formation of the 6-mercaptopurine complex by the sulfur atom ( Figure 2(D) ) [ 39 ]. An absorption band at 428 cm −1 in the FPEGMP-2 nanocomposite proved the presence of magnetite nanoparticles after coating procedure.…”

Section: Resultsmentioning

confidence: 99%

Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System

Dorniani

Kura

Hussein‐Al‐Ali

et al. 2014

The Scientific World Journal

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The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.

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Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model

et al. 2022

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Purpose We tend to evaluated a method for loading 6Mercaptopurine (6MP) on green synthesized hybrid chitosan gold nanoparticles (AuNPs) forming 6MP-AuNPs nanocomposite for the first time in combinatorial chemo-photothermal therapy. Methods The AuNPs were synthesized using chitosan as a reducing and capping agent. Different concentrations of 6MP were mixed AuNPs. Cells were incubated with 6MP and 6MP loaded AuNPs for 48 h and then exposed to laser. Results AuNPs and 6MP-AuNPs nanocomposite have small sizes of 18 ± 4 and 25 ± 5 nm and exhibit high stability with Zeta potential of 55.9 ± 6.3 and 57 ± 4 mV. 6MP-AuNPs nanocomposite irradiated with Diode Pumped Solid State (DPSS) laser showed a maximum inhibition in cell viability reaching 63% at 1.25 µM. Conclusions A hybrid chitosan gold nanoparticle is a powerful anti-cancer drug carrier as well as photothermal agent in combinatorial chemo-photothermal therapy.

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Magnetic Study of the Novel Polynuclear Compound [Cu(II)(6-Mercaptopurinolate2−)]n

Cited by 10 publications

References 18 publications

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System

Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Model

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