Magnetic separation in microfluidic systems using microfabricated electromagnets—experiments and simulations

Smistrup, Kristian; Hansen, Ole; Bruus, Henrik; Hansen, Mikkel Fougt

doi:10.1016/j.jmmm.2005.01.079

Cited by 134 publications

(97 citation statements)

References 8 publications

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“…19 While useful, these investigations do not provide a quantitative particle-tracking model that is applicable regardless of configuration and geometry. Previous simulations of magnetic particle transport in microfluidic contexts 20 have also not focused on individual particle trajectories or detailed parametric analyses. Mikkelsen and Bruus 21 offered a theoretical analysis on the microfluidic transport and capture of 1 m diameter magnetic microspheres.…”

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confidence: 99%

Single magnetic particle dynamics in a microchannel

Sinha

Ganguly

et al. 2007

Physics of Fluids

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Functionalized magnetic particles are used in micrototal analysis systems since they act as magnetically steered mobile substrates in microfluidic channels, and can be collected for bioanalytical processing. Here, we examine the motion of magnetic microbeads in a microfluidic flow under the influence of a nonuniform external magnetic field and characterize their collection in terms of the magnetic field strength, particle size, magnetic susceptibility, host fluid velocity and viscosity, and the characteristic length scale. We show that the collection efficiency of a magnetic collector depends upon two dimensionless numbers that compare the magnetic and particle drag forces.

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mentioning

confidence: 99%

Single magnetic particle dynamics in a microchannel

Sinha

Ganguly

et al. 2007

Physics of Fluids

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“… m MsV (3) where Ms is the magnetism of magnet and V is the volume of a magnetic nanoparticle. According to (2), the magnetic force on nanoparticle can be increased by increasing the magnetic flux density.…”

Section: Equations Magnetic Equations and Forces 31mentioning

confidence: 99%

The Influence of Magnetic Nanoparticles’ Size on Trapping Efficiency in a Microfluidic Device

Bahadorimehr¹,

Rashemi²,

Majlis³

2015

IJBBB

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Separation techniques in microfluidic devices using magnetic fields are well-known in biomedical applications in disease diagnosis like cancer, drug delivery, and hyperthermia. In this work, a microfluidic system is investigated. Here magnetic nanoparticles are separated from their medium using magnetic force. The whole microfluidic device for separation of functionalized magnetic beads is composed of a fluidic part and a magnetic part. The diameters of applied nanoparticles are 90 nm, 200 nm and 750 nm. In this method, magnetic nanoparticles are injected into a microchannel, the permanent magnet is located under the channel and the magnetic field which is produced by permanent magnet is applied to the nanoparticles, so the magnetic nanoparticles are integrated above the permamnet magnet. Trajectory of particles, velocity, and the location in which magnetic nanoparticles are captured are obtained.

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“…The magnetic separation was performed as previously described by Adams et al, 13 Inglis et al, 14 and Smistrup et al 17 Briefly, a set of three external NeFeB permanent magnets are used to create long-range magnetic field gradients that serve to attract all magnetic particles toward the bottom plane of the IAMS device, where large, short-range magnetic gradients are generated by microfabricated ferromagnetic structures. 13,17 We estimate the maximum time for the long-range force to move the particles to the bottom plane of the device as…”

Section: ͑1͒mentioning

confidence: 99%

Integrated acoustic and magnetic separation in microfluidic channels

Adams

Thévoz

Bruus

et al. 2009

Applied Physics Letters

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With a growing number of cell-based biotechnological applications, there is a need for particle separation systems capable of multiparameter separations at high purity and throughput, beyond what is presently offered by traditional methods including fluorescence activated cell sorting and column-based magnetic separation. Toward this aim, we report on the integration of microfluidic acoustic and magnetic separation in a monolithic device for multiparameter particle separation. Using our device, we demonstrate high-purity separation of a multicomponent particle mixture at a throughput of up to 10 8 particles/ hr.

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Magnetic separation in microfluidic systems using microfabricated electromagnets—experiments and simulations

Cited by 134 publications

References 8 publications

Single magnetic particle dynamics in a microchannel

Single magnetic particle dynamics in a microchannel

The Influence of Magnetic Nanoparticles’ Size on Trapping Efficiency in a Microfluidic Device

Integrated acoustic and magnetic separation in microfluidic channels

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