Magnetic resonance spectroscopy analysis of intramyocellular lipid composition in lipodystrophic patients and athletes

Abstract

1 Context: Paradoxically, intramyocellular lipid (IMCL) accumulation has been linked to both 2 insulin-resistant and to insulin-sensitive (athletes) states. The composition of this lipid store is 3 unknown in these states. 4 Design and Methods:We used a recently validated and potentially widely applicable 1 H 5 magnetic resonance spectroscopy method to compare the compositional saturation index 6 (CH2:CH3 ratio) and concentration independent of composition (CH3) of intramyocellular 7 lipid in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic 8 patients with that of age-and gender-matched athletes (n=14) and healthy controls (n = 41). 9Main Outcome: IMCL compositional saturation index (CH2:CH3 ratio). 10