Magnetic resonance index of activity (MaRIA) and Clermont score are highly and equally effective MRI indices in detecting mucosal healing in Crohn’s disease

Buisson, Anthony; Pereira, Bruno; Goutte, Marion; Reymond, Maud; Allimant, Christophe; Obritin-Guilhen, Hélène; Bommelaer, Gilles; Hordonneau, Constance

doi:10.1016/j.dld.2017.08.033

Cited by 50 publications

(32 citation statements)

References 42 publications

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“…The MaRIA[ 17 - 19 , 22 ] and the Clermont score[ 19 - 21 , 23 , 24 , 48 ] are the two available MRI scores validated against endoscopy to assess ileocolonic activity in patients with CD. We investigated the performances of these two validated scores to detect endoscopic POR.…”

Section: Discussionmentioning

confidence: 99%

Faecal calprotectin and magnetic resonance imaging in detecting Crohn’s disease endoscopic postoperative recurrence

Baillet¹,

Cadiot²,

Goutte³

et al. 2018

WJG

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AIMTo assess magnetic resonance imaging (MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn’s disease (CD).METHODSFrom two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo (5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence (POR) was defined as Rutgeerts’ index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTSApparent diffusion coefficient (ADC) was lower in patients with endoscopic POR compared to those with no recurrence (2.03 ± 0.32 vs 2.27 ± 0.38 × 10-3 mm²/s, P = 0.032). Clermont score (10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement (RCE) (129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity (MaRIA) (7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system (P = 0.056). ADC < 2.35 × 10-3 mm²/s [sensitivity = 0.85, specificity = 0.65, positive predictive value (PPV) = 0.85, negative predictive value (NPV) = 0.65] and RCE > 100% (sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cut-off values to identify endoscopic POR. Clermont score > 6.4 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), MaRIA > 3.76 (sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1 (sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR (114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR (sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSIONFaecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD.

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Section: Discussionmentioning

confidence: 99%

Faecal calprotectin and magnetic resonance imaging in detecting Crohn’s disease endoscopic postoperative recurrence

Baillet¹,

Cadiot²,

Goutte³

et al. 2018

WJG

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“…According to those authors, there is no widely accepted scoring system for grading the inflammatory activity of the disease. However, the Clermont score (31) and the magnetic resonance index of activity (32) have already been validated and have shown good accuracy in the detection of ulcers and of a treatment response in Crohn's disease (33) .…”

Section: Grading the Inflammatory Activity Of Crohn's Diseasementioning

confidence: 99%

Evaluating inflammatory activity in Crohn’s disease by cross-sectional imaging techniques

et al. 2020

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The evaluation of inflammatory bowel activity in patients with Crohn’s disease has traditionally been a challenge, mainly because of the difficulty in gaining endoscopic access to the small bowel. Historically, barium-based contrast studies were the only option for the evaluation of inflammatory activity in Crohn’s disease. They were gradually replaced by cross-sectional imaging techniques, computed tomography enterography (CTE) and magnetic resonance enterography (MRE) now being the modalities of choice for such evaluations. Those two imaging methods have provided important information regarding intestinal wall involvement and extra-intestinal manifestations of Crohn’s disease, not only assessing lesion characteristics and complications but also quantifying inflammatory bowel activity. The objective of this article is to review the main technical aspects of CTE and MRE, together with their indications, contraindications, and limitations, as well as the CTE and MRE imaging characteristics of inflammatory activity in Crohn’s disease.

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“…In detecting severe ulcerative inflammation, again both MR indices performed comparably well in our study, with a sensitivity of 1.0 but slightly reduced specificity (0.81 vs. 0.91 in their study for MaRIA and 0.79 vs. 0.89 for the Clermont score). In a prospective study with 207 ileocolonic segments, in which diagnostic accuracies of both MR indices were tested against the presence of superficial or deep ulcerations in endoscopy, MaRIA and the Clermont score were proven to be equally effective (6). The major distinction between MaRIA and the Clermont score is based on the omission of contrast-enhanced imaging and the addition of DWI in the Clermont score.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Ileocolonic Inflammation in Crohn’s Disease: Which Surrogate Marker Is Better—MaRIA, Clermont, or PET/MR Index? Initial Results of a Feasibility Trial

Langhorst

Koch

et al. 2018

J Nucl Med

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Trial MaRIA, Clermont, or PET/MR Index? Initial Results of a Feasibility −− Marker Is Better Assessment of Ileocolonic Inflammation in Crohn's Disease: Which Surrogate http://jnm.snmjournals.org/content/60/6/851 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http://jnm.snmjournals.org/site/misc/permission.xhtml

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Magnetic resonance index of activity (MaRIA) and Clermont score are highly and equally effective MRI indices in detecting mucosal healing in Crohn’s disease

Cited by 50 publications

References 42 publications

Faecal calprotectin and magnetic resonance imaging in detecting Crohn’s disease endoscopic postoperative recurrence

Faecal calprotectin and magnetic resonance imaging in detecting Crohn’s disease endoscopic postoperative recurrence

Evaluating inflammatory activity in Crohn’s disease by cross-sectional imaging techniques

Assessment of Ileocolonic Inflammation in Crohn’s Disease: Which Surrogate Marker Is Better—MaRIA, Clermont, or PET/MR Index? Initial Results of a Feasibility Trial

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