Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection

Wu, Mingming; Junker, Daniela; Branca, Rosa T.; Karampinos, Dimitrios C.

doi:10.3389/fendo.2020.00421

Cited by 42 publications

(40 citation statements)

References 189 publications

(318 reference statements)

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“…Adipose tissue is a highly specialized tissue and plays a key role in energy mobilization regulation ( Reilly and Saltiel, 2017 ; Zhai et al, 2020 ). Two types of adipose tissue have been found in mammals so far, called white adipose tissue (WAT) and brown adipose tissue (BAT) ( Cannon and Nedergaard, 2004 ; Wu et al, 2020 ). WAT is generally thought as an organ stores excess energy which maintains energy in the form of triglyceride in lipid droplets.…”

Section: Adipose Tissues and Obesitymentioning

confidence: 99%

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Sun

Luo

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders.

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Section: Adipose Tissues and Obesitymentioning

confidence: 99%

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Sun

Luo

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…Recently, MRI begins to be used in BAT research studies as a nonradioactive imaging method. Since BAT has been shown to have different fractions of fatty acids and water content compared with those of WAT, BAT and WAT tissues can be distinguished by MRI [10].…”

Section: Discussionmentioning

confidence: 99%

“…At present, there are many kinds of methods for BAT research, such as proton density fat fraction (PDFF) and T2* mapping, however, these methods are complicated and need expensive device that limit their application. On the contrary, T2 mapping were widely used in the clinical routine, such as heart, cartilage evaluation and so on [8,9], so we think it may be a good candidate for BAT research [10].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Effects of Exercise on Brown Adipose Tissue Volumes and T2 Values Using Magnetic Resonance Imaging at 7 Tesla

Zeng¹,

Gao²,

Shao³

et al. 2021

Preprint

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Rationale and Objectives: We aimed to evaluate the effect of exercise on brown adipose tissue (BAT) volumes and T2 values in mice. Materials and Methods Twenty-five female Kunming mice were divided into two groups, a running group (n = 5) and a control group (n = 20). After 4 months, all magnetic resonance imaging (MRI) scans of mice were performed on a 7 Tesla (7T) MR scanner with T2-weighted imaging (T2WI) and a T2 mapping sequence. Interscapular brown adipose tissue (BAT) volumes and T2 values were measured. To reduce the impact of weight on the results, we compared the ratio of BAT volumes to body weights (V/W). The data are expressed as mean ± SD, the BAT V/W and T2 values were compared between the control and running groups using the Wilcoxon rank-sum test, P < 0.05 were considered statistically significant. Results Interscapular BAT volumes of the running group (n = 5) and control group (n = 20) were (180.09ml ± 59.80 ml) and (99.98ml ± 35.05ml), respectively. The V/W ratios of the running and control groups were (3.83ml/g ± 0.78ml/g) and (2.17ml/g ± 0.56ml/g), respectively. Interscapular BAT T2 values of the running and control groups were (76.07ms ± 10.82ms) and (61.22ms ± 15.98ms), respectively. Significant differences were found in the BAT V/W ratios (P = 0.0003, P < 0.001) and T2 values between the two groups (P = 0.0096, P < 0.05). BAT volume correlated positively with BAT T2 value (r = 0.75, p = 0.00002). Conclusions MRI is a non-invasive and quantitative method for identifying BAT, especially at ultra-high field like 7T. Long-term running increases BAT volume and T2 value, what's more, BAT volume correlates positively with BAT T2 value.

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“…Decreased EFA and increased EFV were associated with higher cardiovascular risk [31]. Furthermore, the latest report suggested that it was EFA, but not EFV, is the independent predictor of obstructive CAD and high-risk plaque [32]. Regrettably, the two studied mentioned above only measured EF in CCS images [14,27], results after the introduction of the contrast agent were unknown.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Epicardial Fat Using Non-contrast Routine Chest-CT: A Consideration of Threshold Adjusting for Fatty Attenuation

Yin

Cheng

Yang

et al. 2021

Preprint

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Background：Role of epicardial fat (EF) had expended from a marker of cardiovascular risk to indicators of several systemic physiological effects and needed to be measured in more scenarios. The present study aimed to determine whether the EF volume (EFV) and mean attenuation (EFA) measured on non-contrast routine chest-CT (RCCT) could be more consistent with that on coronary CT angiography (CCTA) by adjusting the threshold of fatty attenuation. Methods: Totally 83 subjects simultaneously underwent CCTA and RCCT were enrolled. EFV and EFA were quantified on CCTA using threshold of (N30) (-190HU, -30HU) as reference, and also measured on RCCT using threshold of N30, N40 (-190HU, -40HU), N45 (-190HU, -45HU) respectively. Correlation and agreement of EF metrics between two models and differences between groups with coronary plaque (Plaque (+)) and without plaque (Plaque (-)) were analyzed. Results: EFV and EFA from RCCT using N30, N40 and N45 correlated well with reference (EFV: r2=0.974, 0.976, 0.972, P<0.001; EFA: r2=0.516, 0.500, 0.477, P<0.001). Threshold adjusting was able to reduce the mean difference, while increase the difference of EFA. Data measured on CCTA and RCCT both demonstrated the significantly larger EFV of Plaque (+) group than Plaque (-) group (P<0.05). The significantly difference of EFA was only shown on RCCT using N30 (Plaque (+) vs (-): -80±4.4HU vs-78±4HU, P=0.030). Conclusion: The consistency of EFV measured on RCCT could be improved through adjustment of attenuation threshold. The EFA assessment may have additional information relating to underlying pathophysiological status.

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Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection

Cited by 42 publications

References 189 publications

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Exploring the Effects of Exercise on Brown Adipose Tissue Volumes and T2 Values Using Magnetic Resonance Imaging at 7 Tesla

Measurement of Epicardial Fat Using Non-contrast Routine Chest-CT: A Consideration of Threshold Adjusting for Fatty Attenuation

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