Objective: To study the effect of long-distance running on the morphological and T2* assessment of knee cartilage. Methods: 3D-DESS and T2* mapping was performed in 12 amateur marathon runners (age: between 21 and 37 years) without obvious morphological cartilage damage. MRI was performed three times: within 24 h before the marathon, within 12 h after the marathon, and after a period of convalescence of two months. An automatic cartilage segmentation method was used to quantitatively assessed the morphological and T2* of knee cartilage pre- and post-marathon. The cartilage thickness, volume, and T2* values of 21 sub-regions were quantitatively assessed, respectively. Results: The femoral lateral central (FLC) cartilage thickness was increased when 12-h post-marathon compared with pre-marathon. The tibial medial anterior (TMA) cartilage thickness was decreased when 2 months post-marathon compared with pre-marathon. The tibial lateral posterior (TLP) cartilage volume was increased when 12-h post-marathon compared with pre-marathon. The cartilage T2* value in most sub-regions had the upward trend when 12-h post-marathon and restored trend when 2 months post-marathon, compared with pre-marathon. The femoral lateral anterior (FLA) and TMA cartilage volumes were decreased 2 months post-marathon compared with pre-marathon. Conclusions: The marathon had some effects on the thickness, volume, and T2* value of the knee cartilages. The thickness and volume of knee cartilage in most sub-regions were without significantly changes post-marathon compared with pre-marathon. T2* value of knee cartilage in most sub-regions was increased right after marathon and recovered 2 months later. The TLP and TMA subregions needed follow-up after marathon. Advances in knowledge: The morphological and T2* changes of knee cartilage after marathon were evaluated by MRI and automatic segmentation software. This study was the first to use cartilage automatic segmentation software to evaluate the effects of marathon on the morphology and biochemical components of articular cartilage, and to predict the most vulnerable articular cartilage subregions, for the convenience of future exercise adjustment and the avoidance of sports cartilage injury.
Rationale and Objectives: We aimed to evaluate the effect of exercise on brown adipose tissue (BAT) volumes and T2 values in mice. Materials and Methods Twenty-five female Kunming mice were divided into two groups, a running group (n = 5) and a control group (n = 20). After 4 months, all magnetic resonance imaging (MRI) scans of mice were performed on a 7 Tesla (7T) MR scanner with T2-weighted imaging (T2WI) and a T2 mapping sequence. Interscapular brown adipose tissue (BAT) volumes and T2 values were measured. To reduce the impact of weight on the results, we compared the ratio of BAT volumes to body weights (V/W). The data are expressed as mean ± SD, the BAT V/W and T2 values were compared between the control and running groups using the Wilcoxon rank-sum test, P < 0.05 were considered statistically significant. Results Interscapular BAT volumes of the running group (n = 5) and control group (n = 20) were (180.09ml ± 59.80 ml) and (99.98ml ± 35.05ml), respectively. The V/W ratios of the running and control groups were (3.83ml/g ± 0.78ml/g) and (2.17ml/g ± 0.56ml/g), respectively. Interscapular BAT T2 values of the running and control groups were (76.07ms ± 10.82ms) and (61.22ms ± 15.98ms), respectively. Significant differences were found in the BAT V/W ratios (P = 0.0003, P < 0.001) and T2 values between the two groups (P = 0.0096, P < 0.05). BAT volume correlated positively with BAT T2 value (r = 0.75, p = 0.00002). Conclusions MRI is a non-invasive and quantitative method for identifying BAT, especially at ultra-high field like 7T. Long-term running increases BAT volume and T2 value, what's more, BAT volume correlates positively with BAT T2 value.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.