Magnetic Resonance Imaging Signs of Optic Nerve Gliomas in Neurofibromatosis 1

Imes, Richard K.; Hoyt, William F.

doi:10.1016/s0002-9394(14)76780-7

Cited by 90 publications

(24 citation statements)

References 7 publications

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“…Equally important, MRI provides superior contrast resolution around the edges of a tumor, allowing for sharper evaluation of tumor borders. The characteristic T2-weighted MRI appearance of an optic nerve glioma is a fusiform tumor of high signal intensity surrounding a core of lower signal intensity [Imes and Hoyt, 1991]. Often, the intraorbital tumors will appear tortuous or "kinked."…”

Section: Imaging Methodsmentioning

confidence: 99%

Intracranial gliomas in neurofibromatosis type 1

1999

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Optic pathway gliomas and brainstem gliomas are the predominant intracranial neoplasms associated with neurofibromatosis type 1 (NF1). Before the past 15 years, studies of optic pathway gliomas in NF1 were hampered by the inaccurate diagnosis of NF1, the unavailability of noninvasive neuroimaging techniques, and the frequent rendering of what would now be considered unnecessary, overly aggressive therapy. When studied systematically, these tumors behave in a much more benign fashion than their counterparts in children who do not have NF1. While they may cause symptoms in as many of 50% of cases, progression to the point where specific intervention is deemed necessary is unusual. Consequently, screening neuroimaging of asymptomatic patients is unwarranted. Because optic pathway tumors universally arise in children younger than 7 years of age, all such children should undergo yearly ophthalmologic evaluations and annual assessments of growth to monitor for signs of precocious puberty. Am. J. Med. Genet. (Semin. Med. Genet.) 89:38-44, 1999.

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Section: Imaging Methodsmentioning

confidence: 99%

Intracranial gliomas in neurofibromatosis type 1

1999

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“…PAG invariably contains microcystic mucinous degeneration with a high water content yielding long T1 and T2 relaxation times. Thus PAG appears bright on T2 and dark on T1 weighted images (2,4,(6)(7) . MRI displays a double-intensity signal characterized by a circumferential area of CSF-intensity tissue (the neoplasm itself) surrounding and sharply delineating a central linear core (the optic nerve) of opposite signal intensity: this has been termed the "pseudo-CSF" signal (6) .…”

Section: Discussionmentioning

confidence: 96%

“…MRI displays a double-intensity signal characterized by a circumferential area of CSF-intensity tissue (the neoplasm itself) surrounding and sharply delineating a central linear core (the optic nerve) of opposite signal intensity: this has been termed the "pseudo-CSF" signal (6) . An additional characteristic of PAG which can be appreciated radiographically is the "kinking" of optic nerve (7) . The neoplasm that PAG is most likely to be mistaken for is a meningioma.…”

Section: Discussionmentioning

confidence: 99%

Perineural arachnoidal gliomatosis: case report

Pereira

McCulley

2008

Arq. Bras. Oftalmol.

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“…Ultrasound shows a welldefined, homogeneous, fusiform enlargement of the optic nerve that occupies the orbital conus [3]; however, CT and/or MR imaging should always be performed for determining the extent of the tumor. The MR imaging is best to depict the intracanalicular, chiasmatic, or retrochiasmatic extension of the tumor, which usually appears isointense or slightly hyperintense to normal white matter on T1-weighted and T2-weighted images [1,42,43]. Computed tomography shows a well-outlined fusiform enlargement of the optic nerve, of heterogeneous density.…”

Section: Optic Nerve Gliomamentioning

confidence: 99%

Imaging of orbital disorders in pediatric patients

et al. 2003

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The spectrum of orbital lesions occurring in childhood is wide, including a variety of both benign and malignant disorders. Although physical examination and fundoscopy may aid in establishing the diagnosis of retro-ocular lesions, imaging remains a critical step in the evaluation of the pediatric orbit. Ultrasonography, CT, and MR imaging are the primary modalities for the evaluation of the diseased orbit, and careful observation of the characteristic radiological features usually leads to correct diagnosis; however, some of the lesions look very similar and are difficult to differentiate from each other. The purpose of this article is to review the common and unusual entities that may involve the pediatric orbit, to describe the radiological features, and to evaluate the efficacy of US, CT, and MRI in the diagnosis and management of these conditions.

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Magnetic Resonance Imaging Signs of Optic Nerve Gliomas in Neurofibromatosis 1

Cited by 90 publications

References 7 publications

Intracranial gliomas in neurofibromatosis type 1

Intracranial gliomas in neurofibromatosis type 1

Perineural arachnoidal gliomatosis: case report

Imaging of orbital disorders in pediatric patients

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