Magnetic Resonance Imaging of the Idiopathic Inflammatory Myopathies

Curiel, Rodolfo V.; Jones, Robert; Brindle, Kathleen A.

doi:10.1111/j.1749-6632.2009.04386.x

Cited by 33 publications

(21 citation statements)

References 32 publications

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“…Routine MRI performed with T1-weighted and STIR sequences is more sensitive but less specific than biopsy in diagnosis; it is advantageous for optimizing efficacy of classical diagnostic procedures [14]. Its importance is progressively growing, since it allows to noninvasively characterize the distribution and pattern of parenchymal changes and to monitor the disease progression, which has important implications for treatment [13, 15]. …”

Section: Introductionmentioning

confidence: 99%

7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome

Sciorati

Esposito

Campana

et al. 2014

BioMed Research International

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Inflammatory myopathies comprise heterogeneous disorders. Their etiopathogenesis is poorly understood, because of the paucity of informative experimental models and of approaches for the noninvasive study of inflamed tissues. Magnetic resonance imaging (MRI) provides information about the state of the skeletal muscle that reflects various facets of inflammation and remodeling. This technique has been scarcely used in experimental models of inflammatory myopathies. We characterized the performance of MRI in a well-established mouse model of myositis and the antisynthetase syndrome, based on the immunization of wild-type mice with the amino-terminal fragment of histidyl-tRNA synthetase (HisRS). Over an eight-week period following myositis induction, MRI enabled precise identification of pathological events taking place in muscle tissue. Areas of edema and of active inflammation identified by histopathology paralleled muscle modifications detected noninvasively by MRI. Muscles changes were chronologically associated with the establishment of autoimmunity, as reflected by the development of anti-HisRS antibodies in the blood of immunized mice. MR imaging easily appreciated muscle damage and remodeling even if actual disruption of myofiber integrity (as assessed by serum concentrations of creatinine phosphokinase) was limited. Thus, MR imaging represents an informative and noninvasive analytical tool for studying in vivo immune-mediated muscle involvement.

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Section: Introductionmentioning

confidence: 99%

7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome

Sciorati

Esposito

Campana

et al. 2014

BioMed Research International

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“…WB MRI (Fig. 8) demonstrates diffuse, symmetric muscle edema centered predominantly in the shoulder and hip girdles, but also involving the neck flexors, erector spinae, and psoas muscle groups with no significant subcutaneous edema (O'Connell et al 2002;Curiel et al 2009;Adams et al 1995).…”

Section: Inflammatory Myopathiesmentioning

confidence: 98%

“…The etiology of dermatomyositis is thought to be a humorally mediated vascular injury, with perivascular inflammation and perifascicular atrophy resulting in microangiopathy and myocyte necrosis (Dalakas and Hohlfeld 2003;Bohan and Peter 1975;Curiel et al 2009). Dermatomyositis has a bimodal pattern of distribution.…”

Section: Inflammatory Myopathiesmentioning

confidence: 99%

Whole-Body MRI for Evaluation of the Entire Muscular System

Schramm¹,

Weckbach

Eustace

et al. 2013

Magnetic Resonance Imaging of the Skeletal Musculature

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“…Die Elektromyographie wird zunehmend durch Muskelultraschall [1] und Magnetresonanztomographie (MRT; [11,17] …”

Section: Labordiagnostik Und Bildgebende Verfahrenunclassified

Dermatomyositis – update

Volc‐Platzer

2015

Hautarzt

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Dermatomyositis is a rare idiopathic inflammatory myopathy that affects adults and children, mostly female. Hallmarks of the disease are myositis with necrosis, regeneration and perifascicular atrophy accompanied by a typical skin rash with heliotrope erythema, Gottron's sign, Gottron's papules and nail fold changes with splinter hemorrhage. Typical skin symptoms may appear 6 months up to 2 years before muscle involvement (amyopathic dermatomyositis). New myositis-specific antibodies may allow clinicoserologic correlations within a heterogeneous clinical spectrum. Autoantibody profiles, subtype of myositis, overlap with other collagen vascular disorders and/or malignancy (paraneoplastic dermatomyositis) as well as age of the patients all have a considerable impact on course and prognosis. Infections, drugs and tumors may trigger activation of T and B cells, plasmacytoid dendritic cells, overproduction of type I interferons and complement-mediated endothelial cell damage resulting in vasculopathy. UV radiation may also trigger dermatomyositis. Oral corticosteroids (1.5-2.0 mg/kg body weight/day) are the mainstay of treatment until improvement of muscle symptoms and/or normalization of muscle enzymes with subsequent slow tapering. Corticosteroids may be given as monotherapy or combined with steroid-sparing immunosuppressive agents' i.e. azathioprine, methotrexate, mycophenolate mofetil or high-dose intravenous immunoglobulins. Prognosis has improved considerably since use of high-dose corticosteroids, from 50 to 90% response rate. New therapies with biologicals (anti-CD20-, anti-TNFalpha-, anti-interferon antibodies) and Janus kinase inhibitors are currently being evaluated.

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Magnetic Resonance Imaging of the Idiopathic Inflammatory Myopathies

Cited by 33 publications

References 32 publications

7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome

7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome

Whole-Body MRI for Evaluation of the Entire Muscular System

Dermatomyositis – update

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