Magnetic resonance imaging of superficial cartilage lesions: Role of contrast in lesion detection

Mosher, Timothy J.; Pruett, Steven W.

doi:10.1002/(sici)1522-2586(199908)10:2<178::aid-jmri11>3.3.co;2-n

Cited by 28 publications

(43 citation statements)

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“…The relationship between focal cartilage lesions and the overall (global) longitudinal change of cartilage morphology (volumetric tissue loss) is discussed in the following section. (65,(67)(68)(69)(70) (Fig. 4) are currently being investigated in the context of cartilage imaging and have been proposed to provide higher signal efficiency than SPGR (65).…”

Section: Discussionmentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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Section: Discussionmentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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“…Recently, some investigators suggested that 3D double echo in the steady state (DESS) was useful for cartilage imaging [46,47,48,49]. The 3D DESS images can be generated by combining images from first and second echoes in a steady state and it produces high contrast resolution between cartilage and fluid.…”

Section: Mr Imaging Techniques For Cartilage From Conventional Technimentioning

confidence: 99%

Magnetic resonance imaging of articular cartilage

2001

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Recent advances in treatments of the cartilage abnormalities require more information on the extent and shape of cartilage abnormalities and need for early detection of the lesions. In this article we review MR appearance of the cartilage correlated with histology, MR-related artifacts for cartilage imaging, conventional and dedicated MR techniques suitable for the cartilage, and their clinical utilization.

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“…These two sequences show synovial fluid with high signal intensity and cartilage with lower signal intensity. Cartilage surface lesions are detected by differences in contrast between synovial fluid and cartilage (12).…”

Section: Introductionmentioning

confidence: 99%

90°-Flip-angle three-dimensional double-echo steady-state (3D-DESS) magnetic resonance imaging of the knee: Isovoxel cartilage imaging at 3T

Moriya

Miki

Kanagaki

et al. 2014

European Journal of Radiology

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Purpose:The purpose of this study was to investigate whether 3D-double echo steady state (3D-DESS) with improved contrast by setting the FA (Flip angle) at 90° is useful in 3D isotropic cartilage imaging of the knee at 3 T. Materials and Methods:Imaging was performed in 10 healthy volunteers using 3 methods: with 3D-DESS using FA of 25° and 90°, and with true fast imaging with steady-state precession (True-FISP).The signal-to-noise ratio (SNR) of the synovial fluid and cartilage, and contrast-to-noise ratio (CNR) were measured, and mean values were compared. Visual assessment of artifacts was performed with the cartilage divided into 6 regions. Results:There were no significant differences in synovial fluid SNR in the comparison between FA-90° 3D-DESS and True-FISP (P=0.364).A significantly higher cartilage SNR was observed with FA-90° 3D-DESS than with True-FISP (P=0.031). There were no significant differences in synovial fluid-cartilage CNR between FA-90° 3D-DESS and True-FISP (P=0.892). In the evaluation of artifacts, FA-90° 3D-DESS imaging showed a significantly higher score than True-FISP imaging in the patella and trochlea cartilage (P<0.001, P<0.002). Conclusions:FA-90° 3D-DESS is useful in 3D isotropic cartilage imaging of the knee at 3 T.

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Magnetic resonance imaging of superficial cartilage lesions: Role of contrast in lesion detection

Cited by 28 publications

References 0 publications

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Magnetic resonance imaging of articular cartilage

90°-Flip-angle three-dimensional double-echo steady-state (3D-DESS) magnetic resonance imaging of the knee: Isovoxel cartilage imaging at 3T

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