Magnetic resonance imaging of skeletal muscle

Koltzenburg, M; Yousry, Tarek

doi:10.1097/wco.0b013e3282efc322

Cited by 35 publications

(20 citation statements)

References 26 publications

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“…In clinical and experimental studies of denervated muscles, increased signal intensity on T2-or T2FS-weighted images (also on short tau inversion or turbo inversion recovery magnitude sequences), with no appreciable changes on T1-weighted images, has been demonstrated within 4 days of injury, though these changes may evolve over several weeks [1,2,5,[10][11][12][13]15]. Such increased signal is related to the intra-and extracellular water content and could be consistent with an increase in the extracellular space [1,2,8,10,14].…”

Section: Discussionmentioning

confidence: 97%

Magnetic resonance imaging of lower limb musculature in acute motor axonal neuropathy

et al. 2011

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Magnetic resonance imaging (MRI) is an extremely useful technique to diagnose muscle denervation. This report presents an acute motor axonal neuropathy (AMAN) patient in whom, over 2 years, serial clinical-electrophysiological evaluation and MRI examination of lower limb musculature were performed. A 74-year-old patient was admitted with a 24-h history of ascending weakness culminating a few days later in flaccid and areflexic tetraplegia, which was followed by progressive improvement except for severe residual paresis of foot flexors/extensors. Electrophysiological studies showed motor nerve conduction abnormalities characteristic of AMAN, and profuse signs of active denervation in foot and lower leg muscles, and to a much lesser degree in the thigh muscles. On MRI, T2- and T2-fat suppressed (T2FS) images showed an early (up to month 2 after onset) and subtle hypersignal of all four lower leg muscle compartments evolving to an extensive and widespread hypersignal (as of month 6). Progressive hypersignal of lower leg musculature on T1-weighted images, indicative of fatty atrophy, was detected as of the first year. Thigh and pelvic musculature exhibited early and reversible hypersignal on T2 and T2FS images. There was good concordance between clinico-electrophysiological and MRI findings. We conclude that serial MRI may be very useful to evaluate the extent of muscle denervation and to assess clinical course in AMAN.

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Section: Discussionmentioning

confidence: 97%

Magnetic resonance imaging of lower limb musculature in acute motor axonal neuropathy

et al. 2011

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“…A 3D polygonal surface was constructed for each muscle from the boundaries, and MV was calculated from these surfaces (Figure 1). MR image segmentation is a reliable and repeatable method to determine MV (Koltzenburg and Yousry, 2007; Tingart et al, 2003). MV was determined individually for muscles crossing glenohumeral and elbow joints and several forearm muscles (flexor carpi radialis, flexor carpi ulnaris, extensor carpi radialis longus and brevis).…”

Section: Methodsmentioning

confidence: 99%

Characterizing upper limb muscle volume and strength in older adults: A comparison with young adults

Vidt

Daly

Miller

et al. 2012

Journal of Biomechanics

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Aging is associated with loss of muscle volume (MV) and force leading to difficulties with activities of daily living. However, the relationship between upper limb MV and joint strength has not been characterized for older adults. Quantifying this relationship may help our understanding of the functional upper limb declines older adults experience. Our objective was to assess the relationship between upper limb MV and maximal isometric joint moment-generating capacity (IJM) in a single cohort of healthy older adults (age≥65 years) for 6 major functional groups (32 muscles). MV was determined from MRI for 18 participants (75.1±4.3 years). IJM at the shoulder (abduction/adduction), elbow (flexion/extension), and wrist (flexion/extension) was measured. MV and IJM measurements were compared to previous reports for young adults (28.6±4.5 years). On average older adults had 16.5% less total upper limb MV compared to young adults. Additionally, older adult wrist extensors composed a significantly increased percentage of upper limb MV. Older adult IJM was reduced across all joints, with significant differences for shoulder abductors (p<0.0001), adductors (p=0.01), and wrist flexors (p<0.0001). Young adults were strongest at the shoulder, which was not the case for older adults. In older adults, 40.6% of the variation in IJM was accounted for by MV changes (p≤0.027), compared to 81.0% in young adults. We conclude that for older adults, MV and IJM are, on average, reduced but the significant linear relationship between MV and IJM is maintained. These results suggest that older adult MV and IJM cannot be simply scaled from young adults.

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“…Ideally, a moderately weak muscle should be selected (1). In patients with little or no clinically apparent weakness, the use of electromyography (EMG) can effectively identify abnormal muscles (imaging techniques such as muscle ultrasound or magnetic resonance imaging also may be useful in this role) (2).…”

Section: Selection Of Muscle To Biopsymentioning

confidence: 99%

Muscle Histochemistry: Routine Techniques and Their Clinical Use

Saperstein¹

2007

Journal of Histotechnology

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Compared with the processing of many other tissues, muscle requires a large number of histochemical stains in a process that has not been automated. Such procedures remain necessary because the muscle biopsy is an important diagnostic tool. This article will review the clinical role of muscle biopsy, the routine processing of tissue, and discuss the role various histochemical stains play in the clinician's interpretation. (The J Histotechnol 30

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Magnetic resonance imaging of skeletal muscle

Cited by 35 publications

References 26 publications

Magnetic resonance imaging of lower limb musculature in acute motor axonal neuropathy

Magnetic resonance imaging of lower limb musculature in acute motor axonal neuropathy

Characterizing upper limb muscle volume and strength in older adults: A comparison with young adults

Muscle Histochemistry: Routine Techniques and Their Clinical Use

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