Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997–2005)

Beşaltı, Ömer; Pekcan, Zeynep; Şirin, Yusuf Sinan; Erbaş, Gonca

doi:10.2460/javma.228.6.902

Cited by 86 publications

(125 citation statements)

References 29 publications

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“…Under general anesthesia as provided for taking MRI, about 5.0x10 6 NIBM-MSCs suspended in 1.0 ml of PBS were injected through the hemilaminectomy defect intraspinally at three different points. The right location of the needle tip was verified by the appearance of the cerebrospinal fluid coming from the needle, and directed into the spinal cord parenchyma.…”

Section: Cell Transplantation Proceduresmentioning

confidence: 99%

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Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease

Beşaltı

Can²,

Akpinar³

et al. 2015

Turkish Neurosurgery

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AIm:To investigate the effects of neurogenically-induced autologous bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in paraplegic dogs without deep pain perception (DPP) secondary to intervertebral disk disease (IVDD). mATeRIAL and meTHods: Seven dogs which could not be improved neurologically with conventional treatment modalities were included in the study. All dogs were diagnosed by magnetic resonance imaging and surgically treated. Each dog received two times a suspension of autologous 5.0x10 6 NIBM-MSCs, which were positive to CNPase and MAP-2, as well as to GFAP and beta III tubulin into the spinal cord through the hemilaminectomy defect percutaneously, with a 21-day interval.ResuLTs: Two months after cell transplantation, there were no changes except for 1 gait score improvement for 1 of the cases. At the 4th month, gait score had improved 1 score in 5 cases, and one score progress was recorded in proprioception and nociception in 1 case. In eight months-followed up 4 cases were evaluated by the same parameter; gait score had improved in 3 cases, and propriception improved in 2 cases, and nociception improved in 3 cases. CoNCLusIoN:Our findings suggest that utility of autologous NIBM-MSCs for cases with poor prognosis after IVDD can be a promising approach.

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Section: Cell Transplantation Proceduresmentioning

confidence: 99%

“…Acute high velocity disk extrusions generally have a more guarded prognosis than the slow disk extrusions (5,6). Poor clinical outcome is also associated with severe neurological deficits, especially the loss of deep pain perception (DPP) and the duration of its absence in hind limbs (28,34).…”

Section: Introductionmentioning

confidence: 99%

Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease

Beşaltı

Can²,

Akpinar³

et al. 2015

Turkish Neurosurgery

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“…There are different reports that have distinguished the MR signs in dogs with hydrocephalus, cerebellar degeneration, necrotizing encephalitis, granulomatous meningoencephalitis, infarcts, age-related degeneration, spinal cord hernias, wobbler syndrome, arachnoid cysts, syringohydromyelia associated with Chiari-like malformation in the Cavalier King Charles spaniel (Fig. 1), discospondylitis, atlantoaxial instability, meningeal calcification, hydromyelia, mechanical damage, and brain and spinal tumors (Vullo et al 1997, Gonzalo-Orden et al 2000, Kimotsuki et al 2005, Besalti et al 2006, Garosi et al 2006, Okada et al 2006, Matiasek et al 2007, Couturier J et al 2008, Sturges et al 2008, Carrera et al 2009, Cerda-Gonzalez S et al 2009, Young et al 2009, Gavin PR 2011.…”

Section: Indicationsmentioning

confidence: 99%

Most commonly used sequences and clinical protocols for brain and spine magnetic resonance imaging allowing better identification of pathological changes in dogs

Zhalniarovich¹,

Adamiak²,

Pomianowski³

et al. 2013

Polish Journal of Veterinary Sciences

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Magnetic resonance imaging is the best imaging modality for the brain and spine. Quality of the received images depends on many technical factors. The most significant factors are: positioning the patient, proper coil selection, selection of appropriate sequences and image planes. The present contrast between different tissues provides an opportunity to diagnose various lesions. In many clinics magnetic resonance imaging has replaced myelography because of its noninvasive modality and because it provides excellent anatomic detail. There are many different combinations of sequences possible for spinal and brain MR imaging. Most frequently used are: T2-weighted fast spin echo (FSE), T1-and T2-weighted turbo spin echo, Fluid Attenuation Inversion Recovery (FLAIR), T1-weighted gradient echo (GE) and spin echo (SE), high-resolution three-dimensional (3D) sequences, fat-suppressing short tau inversion recovery (STIR) and half-Fourier acquisition single-shot turbo spin echo (HASTE). Magnetic resonance imaging reveals neurologic lesions which were previously hard to diagnose antemortem.

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“…Type I disc herniation is described usually in chondrodystrophic dogs belonging to breeds, such as Pekingese, Dachshund and Beagle, among others (Goggin et al, 1970;Priester, 1976;Brisson et al, 2004), while type II disc herniation is particularly encountered in largebreed dogs, especially the German shepherd (Downes et al, 2009). However, there are reports indicating the presence of type I disc herniation in large-breed, nonchondrodystrophic breeds (Cudia and Duval, 1997;Macias et al, 2002) as well as the occurrence of type II disc herniation in small, chondrodysrophic breed dogs (Besalti et al, 2006;Levine et al, 2006). Extruded disc herniation (EDH) generally shows the expression of most dramatic neurologic deficits (Macias et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Using geographical information system for spatial evaluation of canine extruded disc herniation

et al. 2014

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Abstract. Disc herniation is one of the most common pathologies of the vertebral column in dogs. The aim of this study was to develop a geographical information system (GIS)-based vertebral canal (VC) map useful for spatial evaluation of extruded disc herniation (EDH) in dogs. ArcGIS ® was used to create two-dimensional and three-dimensional maps, in which the VC surface is divided into polygons by lines representing latitude and longitude. Actual locations and directions of the herniated disc material were assessed by a series of 142 computer tomographies of dogs collected between 2005 and 2013. Most EDHs were located on the cervical and transitional regions (thoraco-lumbar and lumbo-sacral) and shown at the level of the ventro-cranial and ventro-central polygons created. Choropleth maps, highlighting the distribution and the location/direction patterns of the EDHs throughout the VC, were produced based on the frequency of the ailment. GIS proved to be a valuable tool in analysing EDH in dogs. Further studies are required for biomechanical analysis of EDH patterns.

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Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997–2005)

Cited by 86 publications

References 29 publications

Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease

Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease

Most commonly used sequences and clinical protocols for brain and spine magnetic resonance imaging allowing better identification of pathological changes in dogs

Using geographical information system for spatial evaluation of canine extruded disc herniation

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