Magnetic resonance imaging findings and prognosis of gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

Hino, Masayuki; Yamaguchi, Ken; Abiko, Kaoru; Yoshioka, Yumiko; Hamanishi, Junzo; Kondoh, Eiji; Koshiyama, Masafumi; Baba, Tsukasa; Matsumura, Noriomi; Minamiguchi, Sachiko; Kido, Aki; Konishi, Ikuo

doi:10.3892/mco.2016.789

Cited by 15 publications

(15 citation statements)

References 11 publications

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“…In the series by Wong, among the 4 cases, visceral metastases were present in 3, with 2 patients dead of the disease and the other alive with progressive disease [7]. Similarly, both cases reported by Hino et al were advanced at diagnosis and the patients died from the disease, one with lung metastases and the other with peritoneal carcinomatosis [4]. This illustrates the importance of separating these neoplasms from conventional Müllerian type mucinous or endometrioid adenocarcinomas, and they should probably be managed as high-grade neoplasms.…”

Section: Introductionmentioning

confidence: 90%

“…The morphology and immunohistochemical profile are suggestive for an infiltrating endometrial adenocarcinoma of mucinous gastrointestinal type, FIGO grade 2 limited to the endometrium (FIGO stage IA). Isolated case reports of primary gastric or gastrointestinal type of endometrial adenocarcinoma have been published to date [1,2,3,4,5,6]. More recently, Wong et al published the largest series of 4 cases, with detailed histologic and immunohistochemical analysis and clearly defined diagnostic criteria [7].…”

Section: Introductionmentioning

confidence: 99%

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Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Stolnicu¹,

Podoleanu²,

Orbán³

et al. 2021

pjp

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Gastrointestinal type of endometrial carcinoma is a newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of endometrium must not show a typical endometrioid component. We present a case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an endometrioid-like component. However, the endometrioid-like component not only did not show classic squamous metaplasia, but was also MUC6-positive, while the positivity for ER/PR was only focal. The recognition of gastric/gastrointestinal differentiation in endometrial carcinomas is best accomplished using both morphology and immunohistochemistry rather than either alone.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Stolnicu¹,

Podoleanu²,

Orbán³

et al. 2021

pjp

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show abstract

“…The validity of the requirement that an endometrioid component be absent, remains to be evaluated. However, at least 4 of the cases reported as MCG had an endometrioid carcinoma component 96,100,101. The author recommends classifying such cases as mixed mucinous carcinomas of the gastrointestinal type/endometrioid carcinoma, with a notation about the proportions of each component.…”

Section: Mucinous Carcinomamentioning

confidence: 99%

“…Mucinous carcinoma of the gastrointestinal type (MCG) is an emerging subtype of mucinous carcinoma that may be of distinct clinicopathologic significance. 18,26,[92][93][94][95][96][97][98][99][100] The entity encompasses tumors with gastric-type morphology, intestinal-type morphology, or both. Although diagnostic criteria for MCG remain unclear, the entity was recognized in the 5th edition of the WHO Classification.…”

Section: Mucinous Carcinomas Of the Gastrointestinal Typementioning

confidence: 99%

Mucinous Proliferations of the Uterine Corpus: Comprehensive Appraisal of an Evolving Spectrum of Neoplasms

Fadare¹

2022

Advances in Anatomic Pathology

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A variety of endometrial lesions may contain mucinous cells. Herein, the author reviews the literature on the classification and clinicopathologic significance of uterine corpus proliferations with a significant mucinous component, assesses the 2020 World Health Organization classification of such lesions, and presents a diagnostic framework. The key epithelial mucinous lesions include mucinous metaplasia, atypical mucinous glandular proliferation and mucinous carcinoma. Each of these categories are classifiable into "usual" and gastrointestinal subtypes, the latter being indicative of intestinal (presence of goblet cells) and/or gastric-type (abundant, pale eosinophilic or clear cytoplasm and well-defined cell borders) morphology. It has been proposed that at least focal expression of gastrointestinal immunohistochemical markers be required for all gastrointestinal type lesions, and for gastrointestinal type atypical mucinous glandular proliferation and carcinoma, minimality or absence of estrogen receptor expression, and the absence of an endometrioid component. Mucinous carcinomas of the usual type, in which > 50% of the tumor is comprised of a mucinous component, are the most common. Morphologic subtypes include mucinous carcinoma with microglandular features and mucinous carcinoma with signet rings (signet ring carcinoma). Endometrioid carcinomas with a less than a 50% mucinous component are classified as endometrioid carcinoma with mucinous differentiation. Several studies have directly compared endometrioid and mucinous carcinomas, the latter presumably of the usual type, with respect to patient outcomes after treatment. All have found no difference in overall and disease free survival between these groups. However, three major studies have found mucinous carcinomas to be associated with a higher risk of lymph node metastases. Nineteen cases of mucinous carcinoma of the gastrointestinal type have been reported, and the limited data on their follow-up after primary treatment suggests that this subtype is more clinically aggressive and should accordingly be classified separately from mucinous carcinomas of the usual type. The morphologic spectrum of mucinous carcinoma of the gastrointestinal type is unclear and continues to evolve. Mucinous change, which may sometimes be extensive, may also be associated with papillary proliferation of the endometrium, adenomyoma of the endocervical type, atypical, and typical adenomyomas. In a curettage or biopsy, intestinal type mucinous epithelium may be indicative of any of the gastrointestinal lesions mentioned above, but may also represent samplings of uterine teratomas, yolk sac tumors, genital and extragenital adenocarcinomas with intestinal differentiation, or lowgrade appendiceal mucinous neoplasms that secondarily involve the endometrium.

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“…Although previous cases of endometrioid adenocarcinoma of the uterus with intestinal-type mucinous differentiation have been described, 5 in recent years, a group from Japan has described 2 cases of primary gastric-type adenocarcinoma of the uterine corpus. 6,7 The patients were middle-aged, postmenopausal women (range = 56-72 years) who presented with vaginal bleeding and/or copious mucinous discharge. They were both found to have deeply invasive endometrial cancer on hysterectomy (greater than 50% myometrial thickness) with positive regional lymph nodes, which was morphologically and immunohistochemically consistent with gastric-type adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Gastric-Type Endometrial Adenocarcinoma: Report of Two Cases in Patients From the United States

et al. 2017

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Gastric-type adenocarcinomas of the uterine cervix have been described within the literature in detail; however, the description of gastric-type endometrial adenocarcinomas is a recent development, with only two cases originating from Japan in the world literature to date. According to these prior reports, the recognition of this pattern of differentiation is critical, as it is often associated with deep myoinvasion, positive regional lymph nodes, and poor outcome despite appropriate adjuvant treatment. We present two cases of endometrial adenocarcinoma with gastric-type differentiation in patients from the United States with superficial myoinvasion and positive patient outcomes. Gastric-type differentiation in endometrial adenocarcinomas is rare and likely underrecognized. Continued reporting of these cases is necessary to further understand the natural history and clinical implications of this entity.

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Magnetic resonance imaging findings and prognosis of gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

Cited by 15 publications

References 11 publications

Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity

Mucinous Proliferations of the Uterine Corpus: Comprehensive Appraisal of an Evolving Spectrum of Neoplasms

Gastric-Type Endometrial Adenocarcinoma: Report of Two Cases in Patients From the United States

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