Magnetic resonance imaging differences between 
dementia with Lewy bodies and Alzheimer's disease: 
a pilot study

Harvey, Graham; Hughes, John; McKeith, Ian G.; Briel, Ruth; Ballard, Clive; Gholkar, A; Scheltens, Philip; Perry, Robert H.; Ince, Paul G.; O’Brien, John T.

doi:10.1017/s0033291798007806

Cited by 47 publications

(32 citation statements)

References 24 publications

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“…However, the degree of GM reduction in the temporal region was much smaller in DLB than in AD (Fig 2). These results are in agreement with those of previous region-ofinterest [11][12][13] and recent VBM 18,19 studies. A greater loss of GM in AD could help explain the results of a neurophysiological study in which there was more severe episodic memory impairment in AD than in DLB.…”

Section: Discussionsupporting

confidence: 94%

“…Volumetric studies have consistently shown a loss of GM in the MTLs, including the hippocampus and amygdala, in patients with DLB. 11,12 Although the regional patterns of cerebral GM atrophy in DLB overlap those of AD, the degree of GM loss in DLB is much lower than that in AD. 11,13 VBM was developed to assess the whole brain structure with a voxel-by-voxel comparison.…”

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confidence: 99%

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Measurement of Gray and White Matter Atrophy in Dementia with Lewy Bodies Using Diffeomorphic Anatomic Registration through Exponentiated Lie Algebra: A Comparison with Conventional Voxel-Based Morphometry

Takahashi

Ishii²,

Miyamoto³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 94%

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confidence: 99%

Measurement of Gray and White Matter Atrophy in Dementia with Lewy Bodies Using Diffeomorphic Anatomic Registration through Exponentiated Lie Algebra: A Comparison with Conventional Voxel-Based Morphometry

Takahashi

Ishii²,

Miyamoto³

et al. 2010

AJNR Am J Neuroradiol

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“…By comparison, we found subjects with DLB demonstrated less atrophy of the hippocampus and parahippocampus. These results are in keeping with recent volumetric studies [5,6].…”

Section: Discussionsupporting

confidence: 93%

“…Recent volumetric studies [5][6][7] have indicated there may be less medial temporal lobe atrophy (MTA) on magnetic resonance imaging (MRI) in DLB compared with AD. However, it is not known whether differences are restricted to medial temporal lobe structures, or occur as part of a more diffuse pattern of temporal lobe atrophy involving lateral structures.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Medial and Lateral Temporal Lobe Atrophy in Dementia with Lewy Bodies and Alzheimer’s Disease: Magnetic Resonance Imaging Volumetric Study

Barber¹,

McKeith²,

Ballard³

et al. 2001

Dement Geriatr Cogn Disord

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Objectives: To compare medial and lateral temporal lobe atrophy on magnetic resonance imaging (MRI) in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD), and to examine the relationship between volumetric indices and cognitive and non-cognitive symptoms. Methods: T₁-weighted 1.0-tesla MRI scans were acquired in elderly subjects with DLB (n = 26; mean age = 75.8 years) and AD (n = 22; 77.3 years) and normal controls (n = 26; 76.2 years). MRI-based volume measurements of the hippocampus, parahippocampus, fusiform gyrus, combined inferior and middle temporal gyri, and superior temporal gyrus were acquired. Results: Hippocampal and parahippocampal volumes were significantly larger in subjects with DLB compared to AD. Differences in hippocampal volumes between DLB and AD were observed across the entire length, and in all subjects with dementia there was a loss of hippocampal asymmetry compared to normal controls. Atrophy of temporal lobe structures correlated with memory impairment in both groups, and with age in DLB. There was no association between atrophy and psychotic symptoms in either group. Conclusions: Subjects with DLB and AD have a different pattern of temporal lobe atrophy with the most striking differences relating to medial rather than lateral temporal lobe structures. These structural differences could explain the relative preservation of memory function in DLB compared to AD.

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“…Our results, while in agreement with other reports of medial temporal lobe atrophy in AD [3,16], question the specificity of this finding regarding the other important subtypes of dementia. Using high resolution coronal MRI, we have recently shown that DLB is associated with less hippocampal atrophy than AD and VaD, which themselves showed a considerable degree of overlap [17,18]. In the current study, however, we did not find differences between DLB and other groups.…”

Section: Discussioncontrasting

confidence: 91%

Medial Temporal Lobe Width on CT Scanning in Alzheimer’s Disease: Comparison with Vascular Dementia, Depression and Dementia with Lewy Bodies

O’Brien

Metcalfe²,

Swann³

et al. 2000

Dement Geriatr Cogn Disord

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A simple linear measurement of the minimum width of the medial temporal lobe (MTL) on angled CT scans has been suggested as an accurate ante-mortem marker for Alzheimer’s disease (AD). To determine the clinical utility and specificity of this finding, we performed angled CT scans with 5-mm slices in 116 subjects referred to a geographically based Old Age Psychiatry service in Newcastle. Diagnoses were of NINCDS/ADRDA AD (n = 69, 36 probable and 33 possible). NINDS/AIREN vascular dementia (VaD, n = 25), consensus criteria for dementia with Lewy bodies (DLB, n = 9) and DSM-IV criteria for major depression (n = 13). Subjects were well matched for age. Minimum MTL width was significantly greater in depressed subjects (13.7 mm) compared to those with dementia, though no differences were seen within the dementia groups (AD 10.8, VaD 10.4, and DLB 10.9 mm). An MTL width below 11.5 mm had a sensitivity of 54% (56/103) and a specificity of 77% (10/13) for distinguishing dementia from depression. We conclude that a single cross-sectional measurement of MTL width on CT does not help differentiate between different types of dementia, though it may provide some supportive evidence when distinguishing depression from dementia.

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Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study

Abstract: Background. Temporal lobe atrophy on magnetic resonance imaging (MRI) has been suggested as a specific diagnostic marker for Alzheimer's disease (AD). No previous comparison with dementia with Lewy bodies (DLB) has been reported.

Cited by 47 publications

References 24 publications

Measurement of Gray and White Matter Atrophy in Dementia with Lewy Bodies Using Diffeomorphic Anatomic Registration through Exponentiated Lie Algebra: A Comparison with Conventional Voxel-Based Morphometry

Measurement of Gray and White Matter Atrophy in Dementia with Lewy Bodies Using Diffeomorphic Anatomic Registration through Exponentiated Lie Algebra: A Comparison with Conventional Voxel-Based Morphometry

A Comparison of Medial and Lateral Temporal Lobe Atrophy in Dementia with Lewy Bodies and Alzheimer’s Disease: Magnetic Resonance Imaging Volumetric Study

Medial Temporal Lobe Width on CT Scanning in Alzheimer’s Disease: Comparison with Vascular Dementia, Depression and Dementia with Lewy Bodies

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