A Comparison of Medial and Lateral Temporal Lobe Atrophy in Dementia with Lewy Bodies and Alzheimer’s Disease: Magnetic Resonance Imaging Volumetric Study

Barber, Robert; McKeith, Ian G.; Ballard, Clive; Gholkar, A; O’Brien, John

doi:10.1159/000051258

Cited by 97 publications

(58 citation statements)

References 32 publications

(40 reference statements)

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“…In general, DLB patients show less severe episodic memory deficits than AD patients, despite suffering similar levels of dementia. This is consistent with previous studies (e.g., Barber, McKeith, Ballard, Gholkar, & O'Brian, 2001) indicating that the medial temporal structures involved in memory are more severely affected in AD than in DLB. The literature on implicit memory indicates that the observed pattern of results (Heindel et al, 1989) also differentiates patients with subcortical and cortical dementias.…”

Section: Discussionsupporting

confidence: 93%

Recognition by familiarity is preserved in Parkinson's without dementia and Lewy-Body disease.

et al. 2010

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Objective:The retrieval deficit hypothesis states that the lack of deficit in recognition often observed in patients with Parkinson's disease is because of the low retrieval requirements of the task, given that these patients have retrieval and not encoding deficits. To test this hypothesis we investigated recognition memory by familiarity in Parkinson's patients and in patients with Lewy Bodies disease and Parkinson with dementia. Method: We analyzed to what extent the experimental groups were able to recognize by familiarity in a typical yes/no recognition memory task. The experimental groups were patients with early nondemented Parkinson's disease, advanced nondemented Parkinson's disease, demented Parkinson's patients, and patients with dementia with Lewy Bodies. We compared their performance with a group of young and another group of old healthy participants. The estimation of familiarity was made by analyzing recognition of word targets and distractors consisting of combinations of different letters in comparison with a condition in which targets and distractors were composed of similar letters, even though subjects were unaware of the independent variable. Results: The results indicate that familiarity was used at the same level by controls, patients with early Parkinson's disease and patients with dementia with Lewy Bodies. Although late Parkinson patients also used familiarity, its effect was only marginally significant. Patients with Parkinson's disease and dementia were not capable of using familiarity in recognition memory. Conclusions: Our results support the retrieval deficit hypothesis as Parkinson's patients without dementia show no deficit in a situation in which the retrieval requirements are minimal.

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Section: Discussionsupporting

confidence: 93%

Recognition by familiarity is preserved in Parkinson's without dementia and Lewy-Body disease.

et al. 2010

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“…182 This volume loss was also significantly greater in demented patients compared with both cognitive impaired and elderly control subjects. Similarly, Grunwald et al 183 found hippocampal volume loss in dementia, and Barber et al 184 found a loss of hippocampal asymmetry in patients with dementia with Lewy bodies (DLB) (as well as AD patients) compared to normal controls. Volumetric MRI of the brain in elderly subjects with lacunes, mild cognitive impairment, a group of patients with dementia, and a group with probable AD revealed hippocampal volume loss in all three patient groups.…”

Section: Dementiamentioning

confidence: 93%

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

2004

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Magnetic resonance imaging (MRI) has opened a new window to the brain. Measuring hippocampal volume with MRI has provided important information about several neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. Smaller hippocampal volumes have been reported in epilepsy, Alzheimer's disease, dementia, mild cognitive impairment, the aged, traumatic brain injury, cardiac arrest, Parkinson's disease, Huntington's disease, Cushing's disease, herpes simplex encephalitis, Turner's syndrome, Down's syndrome, survivors of low birth weight, schizophrenia, major depression, posttraumatic stress disorder, chronic alcoholism, borderline personality disorder, obsessive-compulsive disorder, and antisocial personality disorder. Significantly larger hippocampal volumes have been correlated with autism and children with fragile X syndrome. Preservation of hippocampal volume has been reported in congenital hyperplasia, children with fetal alcohol syndrome, anorexia nervosa, attention-deficit and hyperactivity disorder, bipolar disorder, and panic disorder. Possible mechanisms of hippocampal volume loss in neuropsychiatric disorders are discussed.

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“…In AD, brain atrophy rates are significantly higher, ie, up to 2% to 3 % per year [41,42] and so are atrophy rates of hippocampus (controls, 1.0% to 1.2% per year; AD, 3.0% to 5.9% per year) and in entorhinal cortex (controls, 1.4% to 2.9% per year; AD, 7.1% to 8.4% per year [31,37], ie, structures known to be affected early in AD. Although there is some overlap between the brain regions with the most pronounced atrophy in AD and atrophied brain in other types of dementia, degree of atrophy and pattern of involved brain areas seem to be sufficiently different to allow for a differentiation between various forms of dementia, eg, Lewy Body Disease, Parkinson's disease with dementia, fronto-temporal lobe dementia [43][44][45][46][47][48][49][50].…”

Section: Structural Neuroimagingmentioning

confidence: 99%

Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)

Mueller

Weiner

Thal

et al. 2005

Alzheimer's & Dementia

1,004

753

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With the increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over the last years about the pathomechanisms involved in AD allow for the development of specific treatment strategies aimed at slowing down or even preventing neuronal death in AD. However, this requires also that (1) AD can be diagnosed with high accuracy, because non-AD dementias would not benefit from an AD-specific treatment; (2) AD can be diagnosed in very early stages when any intervention would be most effective; and (3) treatment efficacy can be reliably and meaningfully monitored. Although there currently is no ideal biomarker that would fulfill all these requirements, there is increasing evidence that a combination of currently existing neuroimaging and cerebrospinal fluid (CSF) and blood biomarkers can provide important complementary information and thus contribute to a more accurate and earlier diagnosis of AD. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is exploring which combinations of these biomarkers are the most powerful for diagnosis of AD and monitoring of treatment effects.

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A Comparison of Medial and Lateral Temporal Lobe Atrophy in Dementia with Lewy Bodies and Alzheimer’s Disease: Magnetic Resonance Imaging Volumetric Study

Cited by 97 publications

References 32 publications

Recognition by familiarity is preserved in Parkinson's without dementia and Lewy-Body disease.

Recognition by familiarity is preserved in Parkinson's without dementia and Lewy-Body disease.

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)

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