Magnetic Resonance Imaging Correlates of Memory Impairment in the Healthy Elderly: Association With Medial Temporal Lobe Atrophy but Not White Matter Lesions

O’Brien, John T.; Desmond, Patricia; Ames, David; Schweitzer, Isaac; Tress, Brian W.

doi:10.1002/(sici)1099-1166(199703)12:3<369::aid-gps516>3.3.co;2-m

Cited by 4 publications

(4 citation statements)

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“…It is interesting that the bivariate association between DelRec and the log-transformed WMH variable is significant in normals since some previous studies have also found significant associations between cognition and WMH in healthy elderly (DeCarli et al, 1995;Swan et al, 1998Swan et al, , 2000 while some have not (DeCarli et al, 1996;Kozachuk et al, 1990;O'Brien et al, 1997). A more limited range of WMH in normals may have contributed to these conflicting findings (Gunning-Dixon & Raz, 2000).…”

Section: Wmh and Declarative Memorysupporting

confidence: 78%

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

Petkov

Eberling

et al. 2004

J. Inter. Neuropsych. Soc.

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We sought to identify magnetic resonance-(MR)-imaged structures associated with declarative memory in a community-dwelling sample of elderly Mexican-American individuals with a spectrum of cognitive decline. Measured structures were the hemispheric volumes of the hippocampus (HC), parahippocampal gyrus, and remaining temporal lobes, as well as severity of white matter signal hyperintensities (WMH). Participants were an imaged subsample from the Sacramento Area Latino Study of Aging (SALSA), N 5 122. Individuals were categorized as normal, memory impaired (MI), cognitively impaired non-demented (CIND), or demented. We show that WMH was the strongest structural predictor for performance on a delayed free-recall task (episodic memory) in the entire sample. The association of WMH with delayed recall was most prominent in elderly normals and mildly cognitively impaired individuals with no dementia or impairment of daily function. However, the left HC was associated with verbal delayed recall only in people with dementia. The right HC volume predicted nonverbal semantic-memory performance. We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function. (JINS, 2004, 10, 371-381.)

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Section: Wmh and Declarative Memorysupporting

confidence: 78%

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

Petkov

Eberling

et al. 2004

J. Inter. Neuropsych. Soc.

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“…Characteristics of the study participants are shown in Table 1. The median volume of WMH lesions was 3.34 cm 3 , and the mean volume of whole WMH lesions divided by the total intracranial capacity for all participants was 0.22.…”

Section: Resultsmentioning

confidence: 99%

“…1 Especially in older adults, WMH lesions can cause various physical disorders including cognitive dysfunction, depression, traumatic injury or aspiration pneumonia. [2][3][4][5][6] The main cause of WMH lesions is known to be small vessel diseases. 7,8 The incidence in the Asian population is high, and that in Japanese older adults is over 70%.…”

Section: Introductionmentioning

confidence: 84%

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Volumetric analyses of cerebral white matter hyperintensity lesions on magnetic resonance imaging in a Japanese population undergoing medical check‐up

Honda

Maruyama

Tamura³

et al. 2015

Geriatrics Gerontology Int

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Aim:To clarify growth patterns, spatial distribution and risk factors of cerebral white matter hyperintensity (WMH) lesions on magnetic resonance imaging. Methods:We analyzed volumes of cerebral WMH lesions in those who underwent brain magnetic resonance imaging as a hospital-based health check-up in 2012 and 2013 by using a computational quantitative image analysis software (Software for NeuroImage Processing in Experimental Research). After excluding subjects not suitable for volumetric analyses because of pathological brain conditions, a total of 1047 healthy participants (mean age 56.6 years) were included for the analyses. First, the relationship of computational volumetry and conventional qualitative visual evaluation by Shinohara grading was evaluated. Volumes of WMH lesions were analyzed according to age and the different cerebral lobes. Finally, clinical risk factors associated with WMH lesions were assessed. Results:Volumes of WMH lesions were significantly correlated with Shinohara grading (P < 0.001). WMH lesions significantly enlarged with aging (P < 0.001) except for the occipital lobe, especially in participants aged 50 years or older. Age and systolic blood pressure were significantly related to volumes of WMH lesions in all the lobes, whereas diastolic blood pressure was not related only in the occipital lobe. Conclusion:Based on computational quantitative volumetric analyses, cerebral WMH lesions increased with age, and were associated with blood pressure. However, the occipital lobe was the only exception to these findings. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 43-47.

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Neuropsychiatric Significance of Subcortical Hyperintensity

Campbell¹,

Coffey²

2001

JNP

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Magnetic Resonance Imaging Correlates of Memory Impairment in the Healthy Elderly: Association With Medial Temporal Lobe Atrophy but Not White Matter Lesions

Abstract: HA atrophy on MRI is associated with impaired memory performance in the healthy elderly, while PVL and DWML are not. Further study should determine whether HA atrophy is a risk factor for developing dementia.

Cited by 4 publications

References 0 publications

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

Volumetric analyses of cerebral white matter hyperintensity lesions on magnetic resonance imaging in a Japanese population undergoing medical check‐up

Neuropsychiatric Significance of Subcortical Hyperintensity

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