Magnetic resonance imaging contrast-enhanced relaxometry of breast tumors: an MRI multicenter investigation concerning 100 patients

Éliat, Pierre-Antoine; Dedieu, V.; Bertino, Catherine; Boute, V.; Lacroix, Joëlle; Constans, Jean-Marc; Korvin, B. De; Vincent, Catherine; Bailly, C; Joffre, F.; Certaines, J. de; Vincensini, D.

doi:10.1016/j.mri.2004.01.024

Cited by 37 publications

(33 citation statements)

References 27 publications

(35 reference statements)

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“…Therefore, when we divide K trans by v e to get k ep , the k ep is not changed by the T1 0 variation. Our finding is concordant with a previous report that k ep is more robust across different contrast agents as well as different pharmacokinetic models and is less influenced by the T1 0 (18,19).…”

Section: Discussionsupporting

confidence: 93%

“…This T1 0 estimation bias was seen in breast cancers, where the B 1 inhomogeneity caused a 50% estimation error in tumor T1 0 in the left breast and 7% on the right. The estimated T1 0 values of tumor with B 1 correction were 1391 msec 6 293 in the left breast and 1407 msec 6 237 in the right breast, which are within the literature-reported values (T1 = 1270-1650 msec) (5,17,18).…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

Tsai¹,

Kao²,

Chang³

et al. 2017

Radiology

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) (CCGII Program).q RSNA, 2016 Purpose:To prospectively quantify the effect of T1 estimation in fat by B 1 correction in breast magnetic resonance (MR) imaging at 1.5 T and to examine the subsequent quantitative dynamic contrast material-enhanced parameters in breast cancer with and without B 1 correction. Materials and Methods:This study had institutional review board approval, and informed consent was obtained from 72 patients with breast cancer before breast MR imaging studies were performed between January and July 2015. B 1 + field and variable flip angle (FA) mapping were included in the dynamic contrast-enhanced breast MR imaging protocol with a 1.5-T MR imaging system. Precontrast T1 relaxation in fat and breast tumors was computed with and without B 1 correction. The pharmacokinetic parameters of breast cancer were calculated by using the Tofts model with T1 values before and after B 1 correction. The Mann-Whitney U test and linear regression model were used for statistical analysis. Results:The FA was 19% higher in the left breast and 3% lower in the right breast than the prescribed value. This 22% average FA difference created a 43% T1 estimation bias in fat between the breasts. The T1 variation in fat was reduced to 0.96% after B 1 correction. There was a 50% overestimation and a 7% underestimation of tumor T1 in the left breast and the right, respectively, associated with B 1 error. Assuming T1 after B 1 correction represents the true tumor T1, 41% underestimation in the left breast and 10% overestimation in the right without B 1 correction were seen in the dynamic contrast-enhanced parameters (including the volume transfer constant, or K trans , fraction of extracellular extravascular space, or v e , and blood normalized initial area under the gadolinium concentration curve to 90 seconds, or IAU GC BN90). Conclusion:B 1 correction for more accurate T1 values should be considered for quantitative dynamic contrast-enhanced breast MR imaging, even at 1.5 T, to offset significant systemic error.q RSNA, 2016

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

Tsai¹,

Kao²,

Chang³

et al. 2017

Radiology

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“…The results presented in Figures 5,6,7,8,9, and 10 answer the five questions the study was set out to address. Figure 5 shows a plot of the average distance, in pixels, over all participants, between the location of the area of maximum metabolic activity selected on the MRI and the PET grayscale images when viewed side-by-side.…”

Section: Resultsmentioning

confidence: 99%

“…In this context, F-18-FDG PET [2][3][4][5] and highresolution and dynamic contrast-enhanced MRI [6][7][8][9][10][11] have steadily gained acceptance in addition to X-ray mammography and ultrasonography. Initial experience with combined PET (functional imaging) and MRI (anatomical localization) has yielded positive results, providing benefits compared to either modality alone [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Novel Genetic Algorithm Generated Schemes for Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) Image Fusion

Baum

Schmidt²,

Rafferty

et al. 2011

J Digit Imaging

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The use and benefits of a multimodality approach in the context of breast cancer imaging are discussed. Fusion techniques that allow multiple images to be viewed simultaneously are discussed. Many of these fusion techniques rely on the use of color tables. A genetic algorithm that generates color tables that have desired properties such as satisfying the order principle, the rows, and columns principle, have perceivable uniformity and have maximum contrast is introduced. The generated 2D color tables can be used for displaying fused datasets. The advantage the proposed method has over other techniques is the ability to consider a much larger set of possible color tables, ensuring that the best one is found. We asked radiologists to perform a set of tasks reading fused PET/ MRI breast images obtained using eight different fusion techniques. This preliminary study clearly demonstrates the need and benefit of a joint display by estimating the inaccuracies incurred when using a side-by-side display. The study suggests that the color tables generated by the genetic algorithm are good choices for fusing MR and PET images. It is interesting to note that popular techniques such as the Fire/Gray and techniques based on the HSV color space, which are prevalent in the literature and clinical practice, appear to give poorer performance.

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“…Such imaging has been used extensively to evaluate the efficacy of anti-angiogenic therapy in murine models [50]- [52]. Moreover, given the millions of doses of low molecular weight gadolinium chelates that have been routinely administered to patients, the use of such agents for calculating in humans angiogenic status of tumors before and after therapy is an attractive approach [53]- [55].…”

Section: Angiogenesismentioning

confidence: 99%

Molecular MR Imaging Probes

Mahmood

Josephson

2005

Proc. IEEE

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Magnetic resonance imaging contrast-enhanced relaxometry of breast tumors: an MRI multicenter investigation concerning 100 patients

Cited by 37 publications

References 27 publications

B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

Evaluation of Novel Genetic Algorithm Generated Schemes for Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) Image Fusion

Molecular MR Imaging Probes

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Magnetic resonance imaging contrast-enhanced relaxometry of breast tumors: an MRI multicenter investigation concerning 100 patients

Cited by 37 publications

References 27 publications

B1 Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

B1 Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

Evaluation of Novel Genetic Algorithm Generated Schemes for Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) Image Fusion

Molecular MR Imaging Probes

Contact Info

Product

Resources

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B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T

B₁ Field Correction of T1 Estimation Should Be Considered for Breast Dynamic Contrast-enhanced MR Imaging Even at 1.5 T