Molecular MR Imaging Probes

Mahmood, Umar; Josephson, Lee

doi:10.1109/jproc.2005.844264

Cited by 7 publications

(1 citation statement)

References 78 publications

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“…New generations of MRI contrast agents are being used to track cells, target specific molecules, and visualize molecular events in vivo [1,2]. Many of these contrast agents utilize highly paramagnetic species, such as superparamagnetic iron-oxide (SPIO) nanoparticles [3].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Detection of Paramagnetic Contrast Agents in Magnetic Resonance Images Via Phase Image Cross-Correlation Analysis

Mills

Ahrens

3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.

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Metal-ion based magnetic resonance imaging (MRI) contrast agents can be used to non-invasively track cells, target specific molecules, and watch gene expression in vivo. However, it is often difficult to detect and interpret the subtle image contrast changes produced by these agents if the biodistribution is not known a priori. Sensitive post-processing methods are needed to help identify localized accumulations of contrast agent and to minimize false positives and negatives. Towards these goals, we apply image cross-correlation methods to MRI phase images to highlight the characteristic magnetic susceptibility pattern created by magnetic dipoles in a magnetic field. We show that this method is very effective in highlighting localized paramagnetic deposits. We investigate the detection limits of this cross-correlation method, and we find that it can be used even for images with a very low signal-to-noise ratio (< 4). This method can be used alongside existing magnitude MRI methods, requires no extra scan time, and can be applied retrospectively to previously acquired data.

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Section: Introductionmentioning

confidence: 99%

Enhanced Detection of Paramagnetic Contrast Agents in Magnetic Resonance Images Via Phase Image Cross-Correlation Analysis

Mills

Ahrens

3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006.

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Preclinical Applications of Magnetic Resonance Imaging in Oncology

Reichardt

Elverfeldt

2020

Recent Results in Cancer Research

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Preclinical Molecular Imaging Using PET and MRI

Wolf

Abolmaali

2012

Molecular Imaging in Oncology

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Molecular imaging fundamentally changes the way we look at cancer. Imaging paradigms are now shifting away from classical morphological measures towards the assessment of functional, metabolic, cellular, and molecular information in vivo. Interdisciplinary driven developments of imaging methodology and probe molecules utilizing animal models of human cancers have enhanced our ability to non-invasively characterize neoplastic tissue and follow anti-cancer treatments. Preclinical molecular imaging offers a whole palette of excellent methodology to choose from. We will focus on positron emission tomography (PET) and magnetic resonance imaging (MRI) techniques, since they provide excellent and complementary molecular imaging capabilities and bear high potential for clinical translation. Prerequisites and consequences of using animal models as surrogates of human cancers in preclinical molecular imaging are outlined. We present physical principles, values and limitations of PET and MRI as molecular imaging modalities and comment on their high potential to non-invasively assess information on hypoxia, angiogenesis, apoptosis, gene expression, metabolism, and cell trafficking in preclinical cancer research.

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Molecular MR Imaging Probes

Cited by 7 publications

References 78 publications

Enhanced Detection of Paramagnetic Contrast Agents in Magnetic Resonance Images Via Phase Image Cross-Correlation Analysis

Enhanced Detection of Paramagnetic Contrast Agents in Magnetic Resonance Images Via Phase Image Cross-Correlation Analysis

Preclinical Applications of Magnetic Resonance Imaging in Oncology

Preclinical Molecular Imaging Using PET and MRI

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